Diet Supplemented with Chia Flour did not Modified the Inflammatory Process and Tumor Development in Wistar Rats Inoculated with Walker 256 Cells.

Chia seed (Salvia hispanica L.) contains high amounts of n-3 α-linolenic acid (ALA) and has been associated with many health benefits. The aim of the present study was to evaluate the AIN-93 diet supplemented by chia flour on cancer-cachexia development and tissues inflammatory response. Wistar rats at 30 days old were treated with control diet or diet supplemented with chia flour for eight weeks. After this period, half of the animals in each diet group were inoculated with Walker 256 tumor cells. On the 14th day after tumor inoculation, the animals were euthanized and white adipose tissue depots, liver, gastrocnemius muscle, and tumor were removed. The tumor weight was higher and IL-10 content was lower in chia flour group. The tumor bearing did not modify the cytokines content in gastrocnemius muscle, retroperitoneal and epididymal adipose tissue, however, it decreased IL-1ß and TNF-α content in liver, and IL6R and IL-10R protein content in mesenteric adipose tissue. In conclusion, our results demonstrated that supplementation with chia flour did not prevent the tumor bearing effects in Walker 256 model.

Reliability and construct validity of the Long Version of Disability Assessment for Dementia (Brazilian Version) / Confiabilidade e validade de construto da Escala de Avaliação de Incapacidade na Demência - Versão Longa (DADL-BR)

Abstract Objectives Evaluate the reliability test-retest (intra and inter-examiner) and construct validity of the Long Version of Disability Assessment for Dementia (Brazilian Version - DADL-BR). Methods The DADL-BR was applied to 58 caregivers/family of older adults with dementia. The inter-examiner (n = 30) and intra-examiner (n = 28) reliability was assessed using the kappa test and Pearson's correlation coefficient, and the internal consistency was assessed using Cronbach's alpha. The construct validity (n = 48) was performed by comparing DADL-BR with MMSE. Results The results of the intra and inter-examiner demonstrated good reliability (0.72 and 0.74), as well as nearly perfect correlations (0.99) for both inter- and intra-examiner reliability. The internal consistency was excellent (0.87) and the results demonstrated a good correlation (0.74) between DADL-BR and MMSE in construct validity analysis. Conclusions DADL-BR can be considered reliable instrument and with good construct validity, considering internal consistency and test-retest reliability and may be constitute a useful instrument for assessing the occupational performance profile of older adults with dementia.

Resumo Objetivos Avaliar a confiabilidade teste-reteste (intra e inter-examinadores) e a validade de construto da Versão Longa da Escala de Avaliação de Incapacidade na Demência - Versão Longa (DADL-BR). Métodos O DADL-Br foi aplicado em 58 cuidadores/familiares de idosos com demência. A confiabilidade inter-examinadores (n = 30) e intrae-xaminadores (n = 28) foi avaliada pelo teste kappa e coeficiente de correlação de Pearson, e a consistência interna foi avaliada pelo Alfa de Cronbach. A validade de construto (n = 48) foi realizada comparando-se o DADL-BR com o Mini Exame do Estado Mental (MEEM). Resultados Os resultados intra e inter-examinadores demonstraram boa confiabilidade (0,72 e 0,74), bem como correlações quase perfeitas (0,99) tanto para confiabilidade inter quanto intra-examinadores. A consistência interna foi excelente (0,87) e os resultados demonstraram boa correlação (0,74) entre o DADL-BR e o MEEM na análise de validade de constructo. Conclusões O DADL-BR pode ser considerado um instrumento confiável e com boa validade de constructo, considerando-se a consistência interna e a confiabilidade teste-reteste, e útil para avaliar o perfil de desempenho ocupacional de idosos com demência.