Detalhe da pesquisa
1.
Identification of a Novel Subtype-Selective α1B-Adrenoceptor Antagonist.
ACS Chem Neurosci
; 15(3): 671-684, 2024 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38238043
2.
Fragment screening by weak affinity chromatography: comparison with established techniques for screening against HSP90.
Anal Chem
; 85(14): 6756-66, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23806099
3.
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.
Bioorg Med Chem Lett
; 22(2): 901-6, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209458
4.
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg Med Chem
; 20(22): 6770-89, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23018093
5.
PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.
RSC Med Chem
; 13(11): 1341-1349, 2022 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36426238
6.
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.
Bioorg Med Chem Lett
; 19(20): 5945-9, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19733067
7.
Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.
Bioorg Med Chem
; 17(18): 6590-605, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19695884
8.
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.
J Med Chem
; 60(6): 2271-2286, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199108
9.
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
J Med Chem
; 52(15): 4794-809, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19610616
10.
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Bioorg Med Chem Lett
; 17(14): 3880-5, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17570665
11.
Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets.
J Chem Inf Comput Sci
; 44(6): 2157-66, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15554686