Information to Help Stalking Victims on College and University Websites: It's Not Easy to Find.

Content analysis was used to explore the availability, type, and location of stalking prevention and intervention information posted on publicly available Institutions of Higher Education (IHE) websites. A stratified sample representing 20% of the IHEs in the United States (N = 619) across 12 stratified groups identified significant gaps in the information provided. A fourth of the sites posted no information about stalking of any kind. Of those that do include such information, much is difficult to find and focused on reporting to IHE authorities. Definitions, training, and other victim-focused resources are rarely included. Comparisons based on IHE student population (i.e., size) and residential characteristics (i.e., setting) identified notable variations across IHE classification groups. From these identified differences, recommendations to improve information delivery and accessibility are discussed.

DNA methylation status predicts cell type-specific enhancer activity.

Cell-selective glucocorticoid receptor (GR) binding to distal regulatory elements is associated with cell type-specific regions of locally accessible chromatin. These regions can either pre-exist in chromatin (pre-programmed) or be induced by the receptor (de novo). Mechanisms that create and maintain these sites are not well understood. We observe a global enrichment of CpG density for pre-programmed elements, and implicate their demethylated state in the maintenance of open chromatin in a tissue-specific manner. In contrast, sites that are actively opened by GR (de novo) are characterized by low CpG density, and form a unique class of enhancers devoid of suppressive effect of agglomerated methyl-cytosines. Furthermore, treatment with glucocorticoids induces rapid changes in methylation levels at selected CpGs within de novo sites. Finally, we identify GR-binding elements with CpGs at critical positions, and show that methylation can affect GR-DNA interactions in vitro. The findings present a unique link between tissue-specific chromatin accessibility, DNA methylation and transcription factor binding and show that DNA methylation can be an integral component of gene regulation by nuclear receptors.

Getting by after a loved one's death by homicide: the relationship between case status, trauma symptoms, life satisfaction, and coping.

Covictims of homicide are the loved ones of people killed by homicide. As secondary victims, they experience trauma from the crime yet are not the focus of criminal justice system (CJS) processes. The current descriptive-exploratory study seeks to better understand this often hidden population by exploring the relationship between CJS case status, trauma symptoms, life satisfaction, and coping with a group of 137 covictims from the Mid-South region of the United States. Findings indicate that case closure does not resolve trauma symptoms, although symptoms do lessen. In addition, a broad range of helping services and coping strategies are used after the homicide. Some are associated with CJS case status, trauma symptoms, and life satisfaction whereas others are not. These findings highlight important areas for future research.

Sexual Assault Information Posted on College and University Websites: Size and Setting Matter.

To better understand what and how institutions of higher education (IHEs) communicate information about sexual assault (SA) on their websites, the current cross-sectional descriptive exploratory study analyzed a stratified sample representing 15% of the IHE websites in the United States. Findings show the availability, location, and type of SA information posted on IHE websites differ based on student population and residential character. Large and primarily residential schools are more likely to include SA information, across multiple pages, with a wider informational span than other categories. However, informational gaps are apparent across all websites. Implications for policy and practice are highlighted.

Expression, purification, and characterization of multiple, multifunctional human glucocorticoid receptor proteins.

The glucocorticoid receptor (GR) is a nuclear receptor protein that plays a central role in glucose homeostasis, the stress response, control of the hypothalamic-pituitary-adrenal axis, and immuno-inflammatory processes via binding of the natural steroid, cortisol. GR is a well-validated drug target and continues to be an important target for new drug discovery efforts. Here, we describe a basic and simple method for Escherichia coli expression and purification of a variety of human GR proteins that contain all three of the functional domains of the protein: the activation function-1 domain, the DNA-binding domain, and the ligand-binding domain. We present characterization data to show that these purified, multifunctional GR proteins are active for ligand, coactivator, and DNA-binding. The work presented here should serve as a reference for future mechanistic, structural and drug discovery efforts that require purified, full or near full length, GR protein.

Women arrested for partner violence and substance use: an exploration of discrepancies in the literature.

Discrepancies exist in research examining substance problems within groups of women arrested for intimate partner violence (IPV). In some studies women IPV arrestees have been found to be at high risk for substance-related problems, whereas in others they are found to be at low risk for substance-related problems. The current study explores these discrepancies then compares a sample of women court ordered to a domestic violence diversion program (n = 78) to a matched sample of men (n = 78) in the same program using police report information, self-report measures, the Substance Abuse Subtle Screening Inventory-3, and the Millon Clinical Multiaxial Inventory-III alcohol and drug subscales. Women IPV arrestees had a low occurrence of substance use during the arresting incident, a low incidence of substance-related diagnoses, and fewer substance-related problems than did men IPV arrestees. However, women demonstrated personality structures susceptible to nondiagnosable, hazardous drinking patterns.

Linking male use of the sex industry to controlling behaviors in violent relationships: an exploratory analysis.

In an attempt to better understand the relationship between male use of the sex industry (i.e., pornography and strip clubs) and interpersonal violence (IPV), 2,135 female residents of an IPV shelter were surveyed regarding their batterer's use of both the sex industry and controlling behaviors in their relationship. Findings indicate that male domestic violence offenders who utilize the sex industry use more controlling behaviors than male domestic violence offenders who do not. Implications for policy, practice, and research are discussed.

A comparison of women versus men charged with intimate partner violence: general risk factors, attitudes regarding using violence, and readiness to change.

The current descriptive study seeks to broaden empirical understanding about women charged with intimate partner violence by comparing a sample of women in a domestic violence diversion program (N = 78) to a matched sample of men (N = 78) in the same program on measurements of general risk factors, attitudes toward using violence, and readiness to change. Findings indicate that the women charged with intimate partner violence are a heterogeneous group, endorse risk factors that show an elevated likelihood they will continue to use violence, demonstrate a high level of tolerance for using violence in their relationship, and may be highly amenable to treatment opportunities. Implications for practice and future research are addressed.

Exploring the link between pet abuse and controlling behaviors in violent relationships.

Domestic violence is not as simple as one partner physically harming another. Instead, it consists of a complex range of controlling behaviors including physical, emotional, sexual, and economic maltreatment as well as isolation, male privilege, blaming, intimidation, threats, and minimizing/denying behaviors. In addition to the controlling behaviors reported by women seeking shelter from violent relationships, a growing body of research indicates some individuals who abuse their intimate partner also abuse their pets. This study explores these connections using reports of 1,283 female pet owners seeking refuge from their male batterer in a domestic violence shelter. Findings indicate that batterers who also abuse their pet (a) use more forms of violence and (b) demonstrate greater use of controlling behaviors than batterers who do not abuse their pets. Likewise, positive correlations are found between specific controlling behaviors and cruelty to pets. Implications for practice and future research are discussed.

Differences and Similarities in Mother and Child Reports About IPV Risks: Concordance Is Likely but Cannot Be Assumed.

Reports from 297 mother-child dyads were compared to explore concurrence in relation to violence committed by the father on specific high-risk items and in terms of general risk to the mother and to the child using composite measures. Results indicated the majority of the mother-child dyads report similar risk using eight individual items (60.9%-77.1%) and on the composite measures (61.9% and 54.2%). However, concordance was lower than anticipated. Findings highlight the importance of not simply relying on parental report but instead obtaining the child's report about their own exposure to intimate partner violence (IPV) in clinical, research, and forensic applications.

Correspondence Between Self-Report Measures and Clinician Assessments of Psychopathology in Female Intimate Partner Violence Survivors.

Intimate partner violence (IPV) has potentially severe and long-lasting mental health consequences for survivors, including elevated symptoms and diagnoses of posttraumatic stress disorder (PTSD), depression, and generalized anxiety disorder (GAD). The current study examined the relationship between three self-report measures of psychological distress and ratings obtained from the corresponding clinician-administered measures in women seeking assessment for mental health problems following IPV ( N = 185). PTSD symptoms were assessed using the self-report Impact of Event Scale-Revised (IES-R) and the interview-based Clinician-Administered PTSD Scale (CAPS). Depression symptoms were assessed using the self-report Beck Depression Inventory-II (BDI-II) and the depressive disorders sections from the clinician-administered Anxiety Disorders Interview Schedule-IV (ADIS-IV). Anxiety symptoms were assessed using the self-report Beck Anxiety Inventory (BAI) and the clinician-administered GAD section from the ADIS-IV. Results indicated that psychological distress was prevalent in the sample, with 27% receiving a PTSD diagnosis, 40% diagnosed with a depressive disorder, and 55% meeting criteria for GAD. Although each self-report measure was significantly and positively correlated with its corresponding clinician-administered measure, rates of diagnostic concordance were mixed. The BDI-II showed a high degree of agreement with the ADIS-IV depression section, but the IES-R and the CAPS were discordant at classifying PTSD. The BAI had acceptable sensitivity but poor specificity in relation to the ADIS-IV GAD section. These findings suggest that multiple assessment modalities should be considered when rating symptoms and estimating the prevalence of diagnoses among survivors of IPV.

Should Programs Designed to Help IPV Survivors Screen for Mental Health-Related Problems: Voices From the Field.

Qualitative responses that 187 service providers gave to a question assessing whether agencies designed to help intimate partner violence (IPV) survivors should screen for mental health-related problems were analyzed using a version of the concept mapping approach. Nine central clusters emerged from the data analysis, which can be linked to three underlying themes: how the identification of mental health-related problems (i.e., labeling) could be misused when working with IPV survivors, ways screening can be appropriately used to help IPV survivors, and barriers that prevent screening. Findings highlight the importance of trauma-informed approaches across all aspects of service delivery.

Enhancing the Impact of Family Justice Centers via Motivational Interviewing: An Integrated Review.

The Family Justice Center (FJC) model is an approach to assisting survivors of intimate partner violence (IPV) that focuses on integration of services under one roof and co-location of staff members from a range of multidisciplinary agencies. Even though the FJC model is touted as a best practice strategy to help IPV survivors, empirical support for the effectiveness of this approach is scarce. The current article consolidates this small yet promising body of empirically based literature in a clinically focused review. Findings point to the importance of integrating additional resources into the FJC model to engage IPV survivors who have ambivalent feelings about whether to accept help, leave the abusive relationship, and/or participate in criminal justice processes to hold the offender accountable. One such resource, motivational interviewing (MI), holds promise in aiding IPV survivors with these decisions, but empirical investigation into how MI can be incorporated into the FJC model has yet to be published. This article, therefore, also integrates the body of literature supporting the FJC model with the body of literature supporting MI with IPV survivors. Implications for practice, policy, and research are incorporated throughout this review.

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling.

Traditional approaches to discovery of selective estrogen receptor modulators (SERMs) have relied on ER binding and cell-based estrogen response element-driven assays to identify compounds that are osteoprotective but nonproliferative in breast and uterine tissues. To discover new classes of potential SERMs, we have employed a cell-free microsphere-based binding assay to rapidly characterize ERalpha interactions with conformation-sensing cofactor or phage display peptides. Peptide profiles of constrained triarenes were compared to known proliferative and nonproliferative ER ligands to discover potent quinoline-based ligands with minimal Ishikawa cell stimulation.

Correlation between in vitro peptide binding profiles and cellular activities for estrogen receptor-modulating compounds.

Numerous biochemical and structural studies have shown that the conformation of the estrogen receptor alpha (ERalpha) can be influenced by ligand binding. In turn, the conformational state of ERalpha affects the ability of the receptor to interact with a wide variety of protein accessory factors. To globally investigate ligand-based cofactor recruitment activities of ERalpha, we have applied a flow cytometric multiplexed binding assay to determine the simultaneous binding of ERalpha to over 50 different peptides derived from both known cofactor proteins and random peptide phage display. Using over 400 ERalpha-binding compounds, we have observed that the multiplexed in vitro peptide-binding profiles are distinct for a number of compounds and that these profiles can predict the effect that ERalpha ligands have on various cellular activities. These cell-based activities include transcriptional regulation at an estrogen response element, MCF-7 cell proliferation, and Ishikawa endometrial cell stimulation. The majority of the compound-induced diversity in the peptide profiling assay is provided by the unique phage display peptides. Importantly, some of these peptides show a sequence relationship with the corepressor motif, suggesting that peptides identified via phage display might represent natural binding partners of ERalpha. These in vitro:cellular correlations may in part explain tissue-specific activities of ERalpha-modulating compounds.

Social problem solving strategies and posttraumatic stress disorder in the aftermath of intimate partner violence.

Social factors are often associated with the development or maintenance of posttraumatic stress disorder (PTSD) in the aftermath of interpersonal traumas. However, social problem solving strategies have received little attention. The current study explored the role of social problem solving styles (i.e., rational approaches, impulsive/careless strategies, or avoidance strategies) as intermediary variables between abuse exposure and PTSD severity among intimate partner violence survivors. Avoidance problem solving served as an intermediating variable for the relationship between three types of abuse and PTSD severity. Rational and impulsive/careless strategies were not associated with abuse exposure. These findings extend the current understanding of social problem solving among interpersonal trauma survivors and are consistent with more general avoidance coping research. Future research might examine whether avoidance problem solving tends to evolve in the aftermath of trauma or whether it represents a longstanding risk factor for PTSD development.

Real-World Barriers to Assessing and Treating Mental Health Problems With IPV Survivors: A Qualitative Study.

Barriers to assessing and treating mental health problems with intimate partner violence (IPV) survivors were identified with qualitative responses from 62 IPV helping professionals who participated in an online survey question. Data were analyzed using a concept mapping approach, which resulted in following eight distinct clusters: (a) unsure, (b) limited IPV specific resources, (c) barriers to access, (d) systems-taboos, (e) immediate crisis needs, (f) fear-stigma, (g) offender's control and (h) cultural concerns. The opinions expressed in these clusters help to better explain logistic, relational, and intrapersonal obstacles that can limit women IPV survivors' ability to receive care for mental health conditions. Extending previous quantitative work by the authors (Simmons, Whalley, & Beck, 2014), the current portion of this project generates new ways of looking at barriers to service delivery, which can be used to develop theory and guide further research.

Discovery of novel nuclear receptor modulating ligands: an integral role for peptide interaction profiling.

There is currently a marketed drug for nearly every nuclear receptor for which the natural ligand has been identified. However, because of the complexity of signal transduction by this class of ligand-regulated transcription factors, few of these drugs have been optimized for pharmaceutical effectiveness. Over the past several years, structural and biochemical work has shed light on some of the ligand-induced features of nuclear receptors that enable them to trigger signal transduction cascades. This review will highlight the use of peptide interactions to cluster different classes of ligands and to identify novel nuclear receptor-modulating ligands as potential drug candidates. Phage display and a multiplexed peptide interaction assay are two of the technologies that are key to this approach. When used as part of a drug discovery platform, this type of biochemical characterization can bridge the gap between high-throughput chemical synthesis and disease model testing. Furthermore, the development of these methodologies is timely because there is a significant medical need for new and improved nuclear receptor drugs that retain beneficial effects but do not have undesired side effect activities.

Use of Mental Health Screening Instruments by Non-Medical Helping Professionals: A Needs Assessment.

When screening women intimate partner violence (IPV) survivors for mental health concerns, helping professionals must balance the very real concerns that arise with diagnostic labels with the equally real difficulties related to mental health problems. To better understand whether and how mental health screening tools can be more useful in this process, the current study reports findings from an online needs assessment. The nationally representative sample included 325 professionals who work with IPV survivors in United States. Overall, participants have a positive attitude about assessing mental health concerns even though most do not conduct such assessments. From this, the following four areas are highlighted: (a) a need for training, (b) the appropriateness of screening, (c) factors that limit use, and (d) assessment tools. Findings also suggest it may be beneficial to develop instruments and/or protocols that are tailored to the unique needs/experiences of IPV survivors.

The validation of the Checklist of Controlling Behaviors (CCB): assessing coercive control in abusive relationships.

The current study addresses the validation of the Checklist of Controlling Behaviors (CCB), an 84-item domestic violence assessment instrument that can be used to address multiple levels of violence and coercive control in violent relationships. Derived from clinical observation and current theories, the CCB makes use of intimate partner violence survivor reports to identify the intensity and frequency of relationship violence. The instrument is divided into 10 subscales including (1) physical abuse, (2) sexual abuse, (3) male privilege, (4) isolation, (5) minimizing and denying, (6) blaming, (7) intimidation, (8) threats, (9) emotional abuse, and (10) economic abuse. To assess validity and reliability of the CCB, 2,135 female volunteers taking refuge at a domestic violence shelter were administered the instrument. Results of principal component analysis of the individual subscales revealed 10 factors having goodness-of-fit values above the desired normative level of .90.