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Objective To evaluate the relationship between sleep and sleepiness with memory complaints. Materials and Methods Patients who were submitted to polysomnography between May and September of 2022 and answered the prospective and retrospective memory questionnaire and the Epworth sleepiness scale were included, respectively. Data were entered into an Excel spreadsheet and converted to a file compatible with the SPSS software. Results The sample consisted of 98 subjects, 62.2% male, mean age of 45.9 years, 73.4% overweight, 54.1% with comorbidities, and 51% with excessive sleepiness. There was a significant difference in sleep efficiency, respiratory disturbance index (RDI), slow wave sleep (SWS), and rapid eye movement (REM) sleep for the group with comorbidities; in latency to sleep and SWS between genders; and in RDI for the body mass index group. No correlation between RDI and memory could be identified, but there were statistically significant correlations between REM and sleep efficiency; RDI and REM sleep; RDI and SWS; SWS and sleep efficiency; and sleep efficiency and latency to sleep onset. Older adults performed better on memory tests when total sleep time (TST) is longer than 5 hours and excessive daytime sleepiness is related to complaints of prospective, retrospective, and total memory. Conclusion Elderly people with TST longer than 5 hours have a better memory. Although a correlation between RDI and memory was not observed, a correlation between excessive daytime sleepiness-one of the main symptoms of patients with sleep disorders-and memory was.
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Background: SARS-CoV-2 binding to ACE2 is potentially associated with severe pneumonia due to COVID-19. The aim of the study was to test whether Mas-receptor activation by 20-hydroxyecdysone (BIO101) could restore the Renin-Angiotensin System equilibrium and limit the frequency of respiratory failure and mortality in adults hospitalized with severe COVID-19. Methods: Double-blind, randomized, placebo-controlled phase 2/3 trial. Randomization: 1:1 oral BIO101 (350 mg BID) or placebo, up to 28 days or until an endpoint was reached. Primary endpoint: mortality or respiratory failure requiring high-flow oxygen, mechanical ventilation, or extra-corporeal membrane oxygenation. Key secondary endpoint: hospital discharge following recovery (ClinicalTrials.gov Number, NCT04472728). Findings: Due to low recruitment the planned sample size of 310 was not reached and 238 patients were randomized between August 26, 2020 and March 8, 2022. In the modified ITT population (233 patients; 126 BIO101 and 107 placebo), respiratory failure or early death by day 28 was 11.4% lower in the BIO101 (13.5%) than in the placebo (24.3%) group, (p = 0.0426). At day 28, proportions of patients discharged following recovery were 80.1%, and 70.9% in the BIO101 and placebo group respectively, (adjusted difference 11.0%, 95% CI [-0.4%, 22.4%], p = 0.0586). Hazard Ratio for time to death over 90 days: 0.554 (95% CI [0.285, 1.077]), a 44.6% mortality reduction in the BIO101 group (not statistically significant). Treatment emergent adverse events of respiratory failure were more frequent in the placebo group. Interpretation: BIO101 significantly reduced the risk of death or respiratory failure supporting its use in adults hospitalized with severe respiratory symptoms due to COVID-19. Funding: Biophytis.
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Resumo Introdução O SARS-CoV-2, responsável pela pandemia de COVID-19, apresenta alta transmissibilidade, principalmente por gotículas respiratórias de pessoas sintomáticas, aperto de mãos ou objetos e superfícies contaminadas, o que eleva a importância da adoção de medidas de redução da transmissibilidade no coletivo. Objetivo Avaliar a prevalência e os fatores associados à realização de medidas preventivas contra SARS-CoV-2/Covid-19. Método Estudo transversal, tipo Web Survey, realizado em Passo Fundo, RS. Coleta de dados on-line com indivíduos de 18 anos ou mais, avaliando aspectos sociodemográficos, de saúde, comportamento e conhecimento sobre o vírus. Desfecho definido como realização de no mínimo oito de nove medidas recomendadas pelo Ministério da Saúde. Estatística descritiva, cálculo de prevalência e razões de prevalência (RP) brutas e ajustadas. Resultados Amostra com 920 participantes, 68% de prevalência do desfecho, associada a mulheres (RP = 1,26; IC = 1,10-1,45), idosos (RP = 1,50; IC = 1,43-1,58), indivíduos que trabalham (RP = 1,09; IC=1,07-1,11), profissionais/estudantes da saúde (RP = 1,12; IC = 1,07-1,17), com 4 ou mais pessoas no domicílio (RP = 0,84; IC = 0,75-0,94) e medo da contaminação (RP = 1,20; IC = 1,17-1,22), do grupo de risco (RP = 0,94; IC = 0,91-0,96), com sinais/sintomas na última semana (RP = 0,83; IC = 0,72-0,96), não fumantes (RP = 1,10; IC = 1,01-1,20) e com conhecimento sobre sinais/sintomas (RP = 1,04; IC = 1,03-1,05), quando procurar atendimento (RP = 1,07; IC = 1,06-1,08) e formas de transmissão (RP = 1,03; IC = 1,00-1,06). Frequência de medidas preventivas variou de 98,5% (evitar aglomerações) a 60,9% (não compartilhar objetos de uso pessoal). Conclusão Mais da metade aderiu às medidas de prevenção, que podem ser reforçadas especialmente entre jovens, homens, do grupo de risco e com conhecimento insuficiente sobre a doença.
Abstract Background SARS-CoV-2, responsible for the COVID-19 pandemic, has high transmissibility, mainly through respiratory droplets from symptomatic people, hand shaking or contaminated objects and surfaces, which raises the importance of adopting measures to reduce transmissibility among individuals in community. Objective To assess the prevalence and factors associated with preventive measures against SARS-CoV-2 / Covid-19. Method This is a Web Survey, cross-sectional study carried out in Passo Fundo, RS. Online data collection with individuals 18 years old or more. Outcome defined as performance of at least eight out of nine measures recommended by the Ministry of Health. Calculation of prevalence, gross and adjusted prevalence ratios (PR). Results Sample of 920 participants, with 68% prevalence of the outcome, associated with women (PR = 1.26; C I= 1.10-1.45), elderly (PR = 1.50; CI=1.43-1.58), working individuals (PR = 1.09; CI = 1.07-1.11), health professionals / students (PR = 1.12; CI = 1.07-1.17), with 4 or more people in the household (PR = 0.84; CI = 0.75-0.94) and fear of contamination (PR = 1.20; CI = 1.17-1.22), belonging to the risk group (PR = 0.94; CI=0.91-0.96), with signs / symptoms in the last week (PR = 0.83; CI =0 .72-0.96), non-smokers (PR = 1.10; CI = 1.01-1.20) and, with knowledge about signs / symptoms (PR = 1.04; CI = 1.03-1.05), when seeking care (PR = 1.07 ; CI = 1.06-1.08) and forms of transmission (PR = 1.03; CI = 1.00-1.06). The frequency of preventive measures ranged from 98.5% (avoiding crowds) to 60.9% (not sharing personal items). Conclusion More than half have adhered to preventive measures, which can be strengthened especially among youth, men, the group at risk and with insufficient knowledge of the disease.
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RESUMO Objetivo: Avaliar a prevalência e os fatores associados à percepção do medo de ser contaminado pelo novo coronavírus. Métodos: Estudo transversal realizado em Passo Fundo, Rio Grande do Sul, com indivíduos de ambos os sexos e 18 ou mais anos de idade. Coleta on-line de dados sociodemográficos, de saúde, de comportamento e de conhecimento acerca do vírus. Análise estatística descritiva e cálculo de prevalência e de razões de prevalência (RP) brutas e ajustadas. Resultados: Amostrados 920 participantes, com 64% de prevalência de medo de contaminação, sendo maior em indivíduos que trabalham (RP = 1,10; IC95 1,02-1,20), com idosos no domicílio (RP = 1,18; IC95 1,17-1,19), percepção negativa da saúde (RP = 1,15; IC95 1,02-1,31), avaliação de elevado risco de contaminação (RP = 1,30; IC95 1,23-1,38), com no mínimo um dos principais sinais/sintomas na semana anterior (RP = 1,12; IC95 1,11-1,13), que realizam maior número de medidas preventivas (RP = 1,27; IC95 1,15-1,40), vacinados contra a gripe (RP = 1,08; IC95 1,07-1,10) e que sabem que pertencem ao grupo de risco (RP = 1,17; IC95 1,14-1,19). Menor probabilidade do desfecho observada em idosos (RP = 0,74; IC95 0,60-0,91), profissionais ou estudantes da saúde (RP = 0,82; IC95 0,81-0,83) e em não fumantes (RP = 0,86; IC95 0,79-0,94). Conclusões: Observou-se elevada proporção de medo entre os participantes, especialmente entre aqueles que se percebem sob maior risco. Considerando o importante papel do medo na saúde mental das pessoas, os achados indicam a importância de intensificar ações educativas e informativas, visando ampliar o esclarecimento da população e reduzir os impactos da pandemia nesse aspecto.
ABSTRACT Objective: To assess the prevalence and factors associated with the perception of fear of being infected by the new coronavirus. Methods: Cross-sectional study carried out in Passo Fundo, Rio Grande do Sul, with individuals of both sexes and 18 years of age or older. Online data collection of sociodemographic, health and behavior characteristics as well as knowledge about the virus. Descriptive statistical analysis and calculation of prevalence and crude and adjusted prevalence ratios (PR). Results: Nine hundred and twenty participants were sampled, with a 64% prevalence of fear of contamination, being higher in working individuals (PR = 1.10; CI95 1.02-1.20), with elderly people at home (PR = 1.18; CI95 1.17-1.19), negative perception of health (PR = 1.15; CI95 1.02-1.31), assessment of high risk of contamination (PR = 1.30; CI95 1.23-1,38), with at least one of the main signs/symptoms in the previous week (PR = 1.12; CI95 1.11-1.13), who perform a greater number of preventive measures (PR = 1.27; CI95 1,15-1.40), vaccinated against influenza (PR = 1.08; CI95 1.07-1.10) and who know that they belong to the risk group (PR = 1.17; CI95 1.14-1,19). Lower probability of outcome observed in the elderly (PR = 0.74; CI95 0.60-0.91), health professionals or students (PR = 0.82; CI95 0.81-0.83) and in non-smokers (PR = 0.86; CI95 0.79-0.94). Conclusions: There was a high proportion of fear among the participants, especially among those who perceive themselves to be at greater risk. Considering the important role of fear in people's mental health, the findings indicate the importance of intensifying educational and informational actions, aiming to expand the clarification of the population and reduce the impacts of the pandemic in this regard.
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Tromboembolia pulmonar é uma afecção aguda que causa uma múltipla variedade deanormalidades clínicas, laboratoriais e radiográficas. A doença pode tanto acompanharcomo mimetizar outras enfermidades cardiopulmonares. Um caso de infarto pulmonarapós tromboembolia simulando pneumonia adquirida na comunidade em uma paciente de42 anos, previamente hígida, é relatado. Este relato de caso visa a confirmar a importânciade incluir tromboembolia pulmonar no diagnóstico diferencial de processos cardiopulmonaresagudos, mesmo se um diagnóstico alternativo é evidente.
Pulmonary thromboembolism is an acute disease that causes a multitude of clinical,laboratorial and radiographics abnormalities. The disease can accompany as well asmimic other cardiopulmonary illnesses. A case of pulmonary infarction following thromboembolismsimulating community-acquired pneumonia, in a previously healthy 42-yearold woman, is described. This article intends to demonstrate, by presenting this case, theimportance of include pulmonary thromboembolism in the differential diagnosis of acutecardiopulmonary diseases, even if an alternative diagnosis is evident.