Detalhe da pesquisa
1.
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.
Antimicrob Agents Chemother
; 58(6): 3233-44, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24663024
2.
Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.
Bioorg Med Chem Lett
; 24(21): 4984-8, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288185
3.
Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein.
J Virol
; 86(12): 6643-55, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22496222
4.
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.
Bioorg Med Chem Lett
; 23(11): 3396-400, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23583513
5.
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.
Bioorg Med Chem Lett
; 23(11): 3401-5, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23601710
6.
Nucleotide competing reverse transcriptase inhibitors: discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Bioorg Med Chem Lett
; 23(9): 2781-6, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23545107
7.
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Bioorg Med Chem Lett
; 23(13): 3967-75, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23673016
8.
Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2775-80, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23511023
9.
Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.
Bioorg Med Chem Lett
; 22(24): 7512-7, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23122820
10.
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.
Bioorg Med Chem Lett
; 21(1): 398-404, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21087861
11.
Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease.
Nat Med
; 8(4): 386-91, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11927945
12.
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Nature
; 426(6963): 186-9, 2003 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14578911
13.
Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.
Bioorg Med Chem Lett
; 19(4): 1199-205, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19138518
14.
Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor.
Nucleic Acids Res
; 32(16): 4758-67, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15356293
15.
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
ACS Med Chem Lett
; 7(8): 797-801, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27563405
16.
Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.
J Med Chem
; 48(17): 5580-8, 2005 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16107158
17.
Isolation and characterization of herpes simplex virus type 1 resistant to aminothiazolylphenyl-based inhibitors of the viral helicase-primase.
Antiviral Res
; 64(3): 161-70, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15550269
18.
Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans.
Org Lett
; 6(17): 2901-4, 2004 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15330643
19.
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.
ACS Med Chem Lett
; 5(6): 711-6, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944749
20.
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
ACS Med Chem Lett
; 5(4): 422-7, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900852