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1.
PLoS Genet ; 18(2): e1009564, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35113854

RESUMO

The olfactory system combines input from multiple receptor types to represent odor information, but there are few explicit examples relating olfactory receptor (OR) activity patterns to odor perception. To uncover these relationships, we performed genome-wide scans on odor-perception phenotypes for ten odors in 1000 Han Chinese and validated results for six of these odors in an ethnically diverse population (n = 364). In both populations, consistent with previous studies, we replicated three previously reported associations (ß-ionone/OR5A1, androstenone/OR7D4, cis-3-hexen-1-ol/OR2J3 LD-band), but not for odors containing aldehydes, suggesting that olfactory phenotype/genotype studies are robust across populations. Two novel associations between an OR and odor perception contribute to our understanding of olfactory coding. First, we found a SNP in OR51B2 that associated with trans-3-methyl-2-hexenoic acid, a key component of human underarm odor. Second, we found two linked SNPs associated with the musk Galaxolide in a novel musk receptor, OR4D6, which is also the first human OR shown to drive specific anosmia to a musk compound. We noticed that SNPs detected for odor intensity were enriched with amino acid substitutions, implying functional changes of odor receptors. Furthermore, we also found that the derived alleles of the SNPs tend to be associated with reduced odor intensity, supporting the hypothesis that the primate olfactory gene repertoire has degenerated over time. This study provides information about coding for human body odor, and gives us insight into broader mechanisms of olfactory coding, such as how differential OR activation can converge on a similar percept.


Assuntos
Percepção Olfatória , Polimorfismo de Nucleotídeo Único , Receptores Odorantes , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Povo Asiático/genética , Benzopiranos/farmacologia , Odor Corporal , Caproatos/farmacologia , Percepção Olfatória/efeitos dos fármacos , Percepção Olfatória/genética , Receptores Odorantes/genética , Reprodutibilidade dos Testes , Olfato/genética
2.
Chem Senses ; 482023 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-37208813

RESUMO

Fear and anxiety are the most frequently studied emotional states in chemosignal research. Despite differences between these two emotional states, findings from research using fear and anxiety body odors (BOs) are often treated as part of a similar phenomenon. In this article, we examine possible similarities and differences between participants exposed to fear and anxiety BOs on 2 dependent variables commonly used in chemosignals' research: (1) the activation of facial muscles in displays of fear expressions (i.e. the medial frontalis and the corrugator supercilii); and (2) the time required to discriminate between negative emotional expressions (fear, anger, and disgust) and neutral ones. Our results show that fear (vs. rest) and anxiety (vs. exercise) BOs activate the medial frontalis, suggesting that both have a similar impact on receivers' facial muscles. However, we could not replicate previous findings regarding the influence of fear BOs in discriminating negative emotional faces from neutral ones. Two additional replication attempts failed to replicate the earlier results, indicating that the results reported in the literature with this specific paradigm should be interpreted cautiously. Suggestions for future research examining possible differences between fear and anxiety BOs are advanced.


Assuntos
Expressão Facial , Músculos Faciais , Humanos , Músculos Faciais/fisiologia , Medo , Emoções/fisiologia , Ansiedade
3.
Chem Senses ; 482023 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-37944028

RESUMO

Abundant evidence indicates that humans can communicate threat-related information to conspecifics through their body odors. However, prior research has been primarily conducted on Western (WEIRD) samples. In this study, we aimed to investigate whether threat-related information can be transmitted by individuals of East Asian descent who carry a single-nucleotide polymorphism (SNP) 538G → A in the ABCC11 gene, which significantly reduces (noticeable) body odor. To examine this, we recruited 18 self-identified male East Asian AA-homozygotes and 18 self-identified male Western individuals who were carriers of the functional G-allele. We collected samples of their fear-related and neutral body odors. Subsequently, we conducted a double-blind behavioral experiment in which we presented these samples to 69 self-identified female participants of Western Caucasian and East Asian backgrounds. The participants were asked to rate faces that were morphed between expressions of fear and disgust. Notably, despite the "odorless" phenotypical expression of the ABCC11-mutation in East Asians, their fear odor caused a perceptual fear bias in both East Asian and Caucasian receivers. This finding leaves open the possibility of universal fear chemosignaling. Additionally, we conducted exploratory chemical analysis to gain initial insights into the chemical composition of the body odors presented. In a subsequent pre-registered behavioral study (N = 33), we found that exposure to hexadecanoic acid, an abundant compound in the fear and neutral body odor samples, was sufficient to reproduce the observed behavioral effects. While exploratory, these findings provide insight into how specific chemical components can drive chemical fear communication.


Assuntos
Odor Corporal , Medo , Humanos , Masculino , Feminino , Odorantes , Polimorfismo de Nucleotídeo Único , Comunicação
4.
Appetite ; 168: 105679, 2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-34500012

RESUMO

How do situations influence food desire? Although eating typically occurs in rich background situations, research on food desire often focuses on the properties of foods and consumers, rather than on the situations in which eating takes place. Here, we take a grounded cognition perspective and suggest that a situation that is congruent with consuming a food increases simulations of eating it, which, in turn, affect desire, and the expected and actual liking of the food. We tested this idea in four pre-registered experiments (N = 524). Participants processed an image of a food presented in a congruent situation, an incongruent situation, or no background situation. Compared to the incongruent situation, the congruent situation increased expected liking of the food and desire, and this was partially or fully mediated by eating simulations. The congruent situation also increased salivation, a physiological indicator of preparing to eat. However, there was only weak and indirect evidence for congruence effects on actual liking of the food when tasted. These findings show that situational cues can affect desire for food through eating simulations. Thus, background situations play an important but understudied role in human food desires. We address implications for research using food images, and for applications to promote healthy and sustainable eating behaviour.


Assuntos
Sinais (Psicologia) , Alimentos , Cognição , Ingestão de Alimentos , Comportamento Alimentar , Preferências Alimentares , Humanos , Paladar
5.
Psychosom Med ; 82(1): 47-56, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31609920

RESUMO

OBJECTIVE: There is evidence that placebo effects may influence hormone secretion. However, few studies have examined placebo effects in the endocrine system, including oxytocin placebo effects. We studied whether it is possible to trigger oxytocin placebo effects using a classical conditioning paradigm. METHODS: Ninety-nine women were assigned to a conditioned, control, or drug control group. In the two-phase conditioning paradigm, participants in the conditioned and drug control groups received an oxytocin nasal spray combined with a distinctive smell (conditioned stimulus [CS]) for three acquisition days, whereas the control group received placebo spray. Subsequently, the conditioned and control groups received placebo spray with the CS and the drug control group received oxytocin spray for three evocation days. Salivary oxytocin was measured several times during each day. Pain sensitivity and facial evaluation tests previously used in oxytocin research were also administered. RESULTS: On evocation day 1, in the conditioned group, oxytocin significantly increased from baseline to 5 minutes after CS (B[slope] = 19.55, SE = 5.88, p < .001) and remained increased from 5 to 20 (B = -10.42, SE = 5.81, p = .071) and 50 minutes (B = -0.70, SE = 3.37, p = .84). On evocation day 2, a trend for increase in oxytocin was found at 5 minutes (B = 15.22, SE = 8.14, p = .062). No placebo effect was found on evocation day 3 (B = 3.57, SE = 3.26, p = .28). Neither exogenous nor conditioned oxytocin affected pain or facial tasks. CONCLUSIONS: Results indicate that oxytocin release can be conditioned and that this response extinguishes over time. Triggering hormonal release by placebo manipulation offers various clinical possibilities, such as enhancing effects of pharmacological treatments or reducing dosages of medications. TRIAL REGISTRATION: The study was registered as a clinical trial on www.trialregister.nl (number NTR5596).


Assuntos
Condicionamento Clássico/fisiologia , Sistemas Neurossecretores/metabolismo , Percepção Olfatória/fisiologia , Ocitocina/administração & dosagem , Ocitocina/metabolismo , Efeito Placebo , Adulto , Feminino , Humanos , Sprays Nasais , Saliva/metabolismo , Adulto Jovem
6.
Behav Res Methods ; 52(4): 1657-1670, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-31965478

RESUMO

Extending traditional research methods for studying the effects of odor on behavior, this study applied virtual reality (VR) to create a real-world, immersive context that was compared with a traditional sterile, non-immersive lab setting. Using precise odor administration with olfactometry, participants were exposed to three odors (cleaning-related pleasant smell, cleaning-unrelated pleasant smell: vanillin, and odorless air). Our aim was to tease apart whether participants' motivation to clean was driven by cleaning associations and/or odor pleasantness, and how context would accentuate these effects. The results indeed showed that, in VR only, the cleaning-related smell elicited faster and more energetic cleaning behavior on a custom-designed cleaning task, and faster and more voluminous olfactory sampling compared with controls (vanillin, air). These effects were not driven by odor valence, given the general absence of significant differences between the pleasant control odor vanillin and odorless air. In sum, combining rigorous experimental control with high ecological validity, this research shows the context dependency of (congruent) odors affecting motivated behavior in an immersive context only.


Assuntos
Odorantes , Realidade Virtual , Feminino , Humanos , Olfatometria , Gravidez , Olfato
7.
Chem Senses ; 43(6): 419-426, 2018 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-29796589

RESUMO

In a double-blind experiment, participants were exposed to facial images of anger, disgust, fear, and neutral expressions under 2 body odor conditions: fear and neutral sweat. They had to indicate the valence of the gradually emerging facial image. Two alternative hypotheses were tested, namely a "general negative evaluative state" hypothesis and a "discrete emotion" hypothesis. These hypotheses suggest 2 distinctive data patterns for muscle activation and classification speed of facial expressions. The pattern of results that would support a "discrete emotions perspective" would be expected to reveal significantly increased activity in the medial frontalis (eyebrow raiser) and corrugator supercilii (frown) muscles associated with fear, and significantly decreased reaction times (RTs) to "only" fear faces in the fear odor condition. Conversely, a pattern of results characterized by only a significantly increased corrugator supercilii activity together with decreased RTs for fear, disgust, and anger faces in the fear odor condition would support an interpretation in line with a general negative evaluative state perspective. The data support the discrete emotion account for facial affect perception primed with fear odor. This study provides a first demonstration of perception of discrete negative facial expressions using olfactory priming.


Assuntos
Expressão Facial , Medo , Odorantes , Suor , Método Duplo-Cego , Humanos
8.
Chem Senses ; 42(8): 663-673, 2017 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-28981822

RESUMO

Alarm pheromones are widely used in the animal kingdom. Notably, there are 26 published studies (N = 1652) highlighting a human capacity to communicate fear, stress, and anxiety via body odor from one person (66% males) to another (69% females). The question is whether the findings of this literature reflect a true effect, and what the average effect size is. These questions were answered by combining traditional meta-analysis with novel meta-analytical tools, p-curve analysis and p-uniform-techniques that could indicate whether findings are likely to reflect a true effect based on the distribution of P-values. A traditional random-effects meta-analysis yielded a small-to-moderate effect size (Hedges' g: 0.36, 95% CI: 0.31-0.41), p-curve analysis showed evidence diagnostic of a true effect (ps < 0.0001), and there was no evidence for publication bias. This meta-analysis did not assess the internal validity of the current studies; yet, the combined results illustrate the statistical robustness of a field in human olfaction dealing with the human capacity to communicate certain emotions (fear, stress, anxiety) via body odor.


Assuntos
Medo , Feromônios Humano , Adolescente , Adulto , Feminino , Humanos , Masculino , Viés de Publicação , Reprodutibilidade dos Testes , Autorrelato , Adulto Jovem
9.
Arch Sex Behav ; 45(5): 1217-26, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-25778405

RESUMO

This study focused on links between romantic attachment, positive body image, and sexual functioning. Dutch female university students (N = 399) completed an online survey that included self-report items about body appreciation, sexual functioning, and romantic attachment. A proposed conceptual model was tested using structural equation modeling and a good fit to the data was found. Results revealed that attachment avoidance in a romantic context was negatively related to sexual arousal, vaginal lubrication, the ability to reach orgasm, and sexual satisfaction. Attachment anxiety was negatively related to body appreciation which, in turn, was positively related to sexual desire and arousal. Findings indicated that romantic attachment is meaningfully linked to body appreciation and sexual functioning. Therefore, the concept of adult attachment may be a useful tool for the treatment of sexual problems of young women.


Assuntos
Transtornos de Ansiedade , Imagem Corporal/psicologia , Comportamento Sexual , Estudantes/estatística & dados numéricos , Adolescente , Adulto , Transtornos de Ansiedade/epidemiologia , Transtornos de Ansiedade/psicologia , Nível de Alerta , Feminino , Humanos , Libido , Comportamento Sexual/psicologia , Comportamento Sexual/estatística & dados numéricos , Universidades , Adulto Jovem
10.
Psychol Sci ; 26(6): 684-700, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25870406

RESUMO

It is well known that feelings of happiness transfer between individuals through mimicry induced by vision and hearing. The evidence is inconclusive, however, as to whether happiness can be communicated through the sense of smell via chemosignals. As chemosignals are a known medium for transferring negative emotions from a sender to a receiver, we examined whether chemosignals are also involved in the transmission of positive emotions. Positive emotions are important for overall well-being and yet relatively neglected in research on chemosignaling, arguably because of the stronger survival benefits linked with negative emotions. We observed that exposure to body odor collected from senders of chemosignals in a happy state induced a facial expression and perceptual-processing style indicative of happiness in the receivers of those signals. Our findings suggest that not only negative affect but also a positive state (happiness) can be transferred by means of odors.


Assuntos
Comunicação , Expressão Facial , Felicidade , Odorantes , Feromônios Humano , Olfato , Adolescente , Adulto , Feminino , Humanos , Modelos Logísticos , Masculino , Autorrelato , Adulto Jovem
12.
Physiol Behav ; 270: 114307, 2023 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-37516230

RESUMO

Humans produce odorous secretions from multiple body sites according to the microbiomic profile of each area and the types of secretory glands present. Because the axilla is an active, odor-producing region that mediates social communication via the sense of smell, this article focuses on the biological mechanisms underlying the creation of axillary odor, as well as the intrinsic and extrinsic factors likely to impact the odor and determine individual differences. The list of intrinsic factors discussed includes sex, age, ethnicity, emotions, and personality, and extrinsic factors include dietary choices, diseases, climate, and hygienic habits. In addition, we also draw attention to gaps in our understanding of each factor, including, for example, topical areas such as the effect of climate on body odor variation. Fundamental challenges and emerging research opportunities are further outlined in the discussion. Finally, we suggest guidelines and best practices based on the factors reviewed herein for preparatory protocols of sweat collection, data analysis, and interpretation.


Assuntos
Odorantes , Suor , Humanos , Olfato , Sudorese , Axila
13.
Perspect Psychol Sci ; : 17456916231188147, 2023 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-37669015

RESUMO

Although chemical signaling is an essential mode of communication in most vertebrates, it has long been viewed as having negligible effects in humans. However, a growing body of evidence shows that the sense of smell affects human behavior in social contexts ranging from affiliation and parenting to disease avoidance and social threat. This article aims to (a) introduce research on human chemical communication in the historical context of the behavioral sciences; (b) provide a balanced overview of recent advances that describe individual differences in the emission of semiochemicals and the neural mechanisms underpinning their perception, that together demonstrate communicative function; and (c) propose directions for future research toward unraveling the molecular principles involved and understanding the variability in the generation, transmission, and reception of chemical signals in increasingly ecologically valid conditions. Achieving these goals will enable us to address some important societal challenges but are within reach only with the aid of genuinely interdisciplinary approaches.

14.
Psychol Sci ; 23(11): 1417-24, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23019141

RESUMO

Can humans communicate emotional states via chemical signals? In the experiment reported here, we addressed this question by examining the function of chemosignals in a framework furnished by embodied social communication theory. Following this theory, we hypothesized that the processes a sender experiences during distinctive emotional states are transmitted to receivers by means of the chemicals that the sender produces, thus establishing a multilevel correspondence between sender and receiver. In a double-blind experiment, we examined facial reactions, sensory-regulation processes, and visual search in response to chemosignals. We demonstrated that fear chemosignals generated a fearful facial expression and sensory acquisition (increased sniff magnitude and eye scanning); in contrast, disgust chemosignals evoked a disgusted facial expression and sensory rejection (decreased sniff magnitude, target-detection sensitivity, and eye scanning). These findings underline the neglected social relevance of chemosignals in regulating communicative correspondence outside of conscious access.


Assuntos
Emoções/fisiologia , Expressão Facial , Percepção Olfatória/fisiologia , Feromônios Humano/fisiologia , Suor/fisiologia , Comunicação , Método Duplo-Cego , Medo/fisiologia , Feminino , Humanos , Masculino , Adulto Jovem
15.
Memory ; 20(4): 346-57, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22537073

RESUMO

The time-course of changes in vividness and emotionality of unpleasant autobiographical memories associated with making eye movements (eye movement desensitisation and reprocessing, EMDR) was investigated. Participants retrieved unpleasant autobiographical memories and rated their vividness and emotionality prior to and following 96 seconds of making eye movements (EM) or keeping eyes stationary (ES); at 2, 4, 6, and 10 seconds into the intervention; then followed by regular larger intervals throughout the 96-second intervention. Results revealed a significant drop compared to the ES group in emotionality after 74 seconds compared to a significant drop in vividness at only 2 seconds into the intervention. These results support that emotionality becomes reduced only after vividness has dropped. The results are discussed in light of working memory theory and visual imagery theory, following which the regular refreshment of the visual memory needed to maintain it in working memory is interfered with by eye movements that also tax working memory, which affects vividness first.


Assuntos
Dessensibilização Psicológica/métodos , Emoções/fisiologia , Movimentos Oculares/fisiologia , Memória Episódica , Memória de Curto Prazo/fisiologia , Transtornos de Estresse Pós-Traumáticos/fisiopatologia , Adolescente , Adulto , Dessensibilização Psicológica/normas , Feminino , Humanos , Imagens, Psicoterapia/métodos , Imagens, Psicoterapia/normas , Masculino , Tempo de Reação/fisiologia , Reprodutibilidade dos Testes , Transtornos de Estresse Pós-Traumáticos/terapia , Adulto Jovem
16.
Cogn Emot ; 26(1): 83-92, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-21547759

RESUMO

According to the Proust phenomenon, olfactory memory triggers are more evocative than other-modality triggers resulting in more emotional and detailed memories. An experimental paradigm was used to investigate this in aversive memories, similar to those experienced by patients with posttraumatic stress disorder. Seventy healthy participants watched an aversive film, while simultaneously being exposed to olfactory, auditory and visual triggers, which were matched on intensity, valence, arousal and salience. During a second session one week later, participants were randomly exposed to one of the three triggers, and asked to think back about the film and to rate the resulting memory. Results revealed that odour-evoked memories of aversive events were more detailed, unpleasant and arousing than memories evoked by auditory, but not visual, triggers.


Assuntos
Emoções , Memória , Odorantes , Percepção Olfatória , Estimulação Acústica/métodos , Estimulação Acústica/psicologia , Nível de Alerta , Percepção Auditiva , Sinais (Psicologia) , Feminino , Humanos , Estimulação Luminosa/métodos , Percepção Visual
17.
J Neurophysiol ; 104(5): 2749-56, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20844114

RESUMO

The aim of the present research was to investigate the influences of cognition on temporal processing of olfactory information in a health-relevant context. We investigated whether expecting an odor to cause adverse health effects alters perception of that odor. An irritation-free odor (Study 1: H(2)S; Study 2: phenyl ethyl alcohol [PEA]) was presented after which participants expected to experience either adverse sensory irritation (caused by intranasal CO(2) presentation) in one condition or no adverse effects in another condition, depending on a previously presented visual cue. Olfactory event-related potentials (OERPs) were measured to assess effects of expectations on the temporal course of olfactory processing. When participants expected irritancy after perceiving the odor of H(2)S, N1 and P3 peak amplitude and N1 latency were increased and shortened, respectively, suggesting more intense and faster processing of the odor as well as effects on salience and anticipation of sensory irritation. When the odor was PEA, only the N1 amplitude was increased. These results, obtained with OERP, provide converging evidence for comparable conclusions regarding the influence of cognition on odor perception reached with functional magnetic resonance imaging. Furthermore, the results suggest that a priori hedonic valence of an odor affects how susceptible the olfactory percept is to modulation via expectations.


Assuntos
Córtex Cerebral/fisiologia , Potenciais Evocados/fisiologia , Irritantes , Odorantes , Percepção Olfatória/fisiologia , Adulto , Análise de Variância , Sinais (Psicologia) , Eletroencefalografia , Feminino , Humanos , Masculino
18.
Chem Senses ; 35(2): 135-45, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20008894

RESUMO

Stimuli from all sensory modalities can be linked to places and thus might serve as navigation cues. We compared performance for 4 sensory modalities in a location memory task: Black-and-white drawings of free forms (vision), 1-s manipulated environmental sounds (audition), surface textures of natural and artificial materials (touch), and unfamiliar smells (olfaction) were presented in 10 cubes. In the learning stage, participants walked to a cube, opened it, and perceived its content. Subsequently, in a relocation task, they placed each stimulus back in its original location. Although the proportion of correct locations selected just failed to yield significant differences between the modalities, the proportion of stimuli placed in the vicinity of the correct location or on the correct side of the room was significantly higher for vision than for touch, olfaction, and audition. These outcomes suggest that approximate location memory is superior for vision compared with other sensory modalities.


Assuntos
Audição/fisiologia , Memória/fisiologia , Olfato/fisiologia , Tato/fisiologia , Percepção Visual/fisiologia , Adolescente , Adulto , Sinais (Psicologia) , Feminino , Humanos , Masculino
19.
Front Psychol ; 11: 581701, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33192899

RESUMO

Communication constitutes the core of human life. A large portion of our everyday social interactions is non-verbal. Of the sensory modalities we use for non-verbal communication, olfaction (i.e., the sense of smell) is often considered the most enigmatic medium. Outside of our awareness, smells provide information about our identity, emotions, gender, mate compatibility, illness, and potentially more. Yet, body odors are astonishingly complex, with their composition being influenced by various factors. Is there a chemical basis of olfactory communication? Can we identify molecules predictive of psychological states and traits? We propose that answering these questions requires integrating two disciplines: psychology and chemistry. This new field, coined sociochemistry, faces new challenges emerging from the sheer amount of factors causing variability in chemical composition of body odorants on the one hand (e.g., diet, hygiene, skin bacteria, hormones, genes), and variability in psychological states and traits on the other (e.g., genes, culture, hormones, internal state, context). In past research, the reality of these high-dimensional data has been reduced in an attempt to isolate unidimensional factors in small, homogenous samples under tightly controlled settings. Here, we propose big data approaches to establish novel links between chemical and psychological data on a large scale from heterogeneous samples in ecologically valid settings. This approach would increase our grip on the way chemical signals non-verbally and subconsciously affect our social lives across contexts.

20.
Metabolites ; 10(3)2020 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-32121157

RESUMO

Chemical communication is common among animals. In humans, the chemical basis of social communication has remained a black box, despite psychological and neural research showing distinctive physiological, behavioral, and neural consequences of body odors emitted during emotional states like fear and happiness. We used a multidisciplinary approach to examine whether molecular cues could be associated with an emotional state in the emitter. Our research revealed that the volatile molecules transmitting different emotions to perceivers also have objectively different chemical properties. Chemical analysis of underarm sweat collected from the same donors in fearful, happy, and emotionally neutral states was conducted using untargeted two-dimensional (GC×GC) coupled with time of flight (ToF) MS-based profiling. Based on the multivariate statistical analyses, we find that the pattern of chemical volatiles (N = 1655 peaks) associated with fearful state is clearly different from that associated with (pleasant) neutral state. Happy sweat is also significantly different from the other states, chemically, but shows a bipolar pattern of overlap with fearful as well as neutral state. Candidate chemical classes associated with emotional and neutral sweat have been identified, specifically, linear aldehydes, ketones, esters, and cyclic molecules (5 rings). This research constitutes a first step toward identifying the chemical fingerprints of emotion.

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