Detalhe da pesquisa
1.
Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects.
Br J Clin Pharmacol
; 83(2): 326-338, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27621150
2.
A Phase 1 first-in-human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF-06730512 in healthy participants.
Pharmacol Res Perspect
; 9(4): e00813, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34369667
3.
De novo lipogenesis is essential for platelet production in humans.
Nat Metab
; 2(10): 1163-1178, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929234
4.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092695
5.
Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity.
Diabetes
; 54(1): 259-67, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15616037
6.
Insulin resistance causes human gallbladder dysmotility.
J Gastrointest Surg
; 10(7): 940-8; discussion 948-9, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16843864
7.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
J Med Chem
; 57(24): 10512-26, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25423286
8.
Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent.
Pharmacogenomics
; 10(12): 1929-39, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19958092
9.
A novel pathway to the manifestations of metabolic syndrome.
Obes Res
; 12(2): 180-6, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14981209
10.
Gallstones: genetics versus environment.
Ann Surg
; 235(6): 842-9, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12035041
11.
Major quantitative trait locus for resting heart rate maps to a region on chromosome 4.
Hypertension
; 43(5): 1146-51, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-14993199
12.
Genetic determinants of obesity-related lipid traits.
J Lipid Res
; 45(4): 610-5, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-14754912