Detalhe da pesquisa
1.
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
Nat Chem Biol
; 20(5): 634-645, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38632492
2.
Sequence-based prediction of pH-dependent protein solubility using CamSol.
Brief Bioinform
; 24(2)2023 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719110
3.
An aggregation inhibitor specific to oligomeric intermediates of Aß42 derived from phage display libraries of stable, small proteins.
Proc Natl Acad Sci U S A
; 119(21): e2121966119, 2022 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35580187
4.
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Proc Natl Acad Sci U S A
; 119(31): e2205412119, 2022 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858383
5.
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform.
Anal Chem
; 95(12): 5362-5368, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36930285
6.
Proteome-wide observation of the phenomenon of life on the edge of solubility.
Proc Natl Acad Sci U S A
; 117(2): 1015-1020, 2020 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31892536
7.
Rational design of a conformation-specific antibody for the quantification of Aß oligomers.
Proc Natl Acad Sci U S A
; 117(24): 13509-13518, 2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32493749
8.
π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation.
J Am Chem Soc
; 144(29): 13026-13031, 2022 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35834748
9.
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data.
PLoS Comput Biol
; 15(5): e1007070, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31120880
10.
MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.
Nucleic Acids Res
; 46(D1): D471-D476, 2018 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29136219
11.
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Proc Natl Acad Sci U S A
; 114(6): E1009-E1017, 2017 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096355
12.
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-ß Oligomers.
Int J Mol Sci
; 21(12)2020 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32630615
13.
Targeting disordered proteins with small molecules using entropy.
Trends Biochem Sci
; 40(9): 491-6, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275458
14.
Parapred: antibody paratope prediction using convolutional and recurrent neural networks.
Bioinformatics
; 34(17): 2944-2950, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672675
15.
Third generation antibody discovery methods: in silico rational design.
Chem Soc Rev
; 47(24): 9137-9157, 2018 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30298157
16.
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.
Proc Natl Acad Sci U S A
; 112(32): 9902-7, 2015 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26216991
17.
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet ß-Cells.
Int J Mol Sci
; 19(5)2018 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29757200
18.
Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.
Proc Natl Acad Sci U S A
; 111(39): 14141-6, 2014 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25228761
19.
Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity Inâ Vivo.
Angew Chem Int Ed Engl
; 56(47): 14963-14967, 2017 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28968001
20.
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.
Biochemistry
; 54(32): 5103-12, 2015 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26192230