Detalhe da pesquisa
1.
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
Biochem J
; 479(5): 661-675, 2022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35179207
2.
Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.
Biochem J
; 476(7): 1037-1051, 2019 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858169
3.
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem J
; 474(22): 3747-3761, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28963344
4.
Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.
Biochem J
; 460(2): 237-46, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24641320
5.
Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
Eur J Med Chem
; 269: 116292, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38479168
6.
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
ChemMedChem
; 18(8): e202200615, 2023 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749883
7.
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
J Med Chem
; 64(18): 13259-13278, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463505
8.
Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.
Chembiochem
; 16(1): 59-63, 2015 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25382253
9.
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
J Med Chem
; 63(13): 6784-6801, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32433887
10.
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
J Med Chem
; 62(12): 5810-5831, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31136173
11.
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.
Cell Rep
; 26(1): 79-93.e8, 2019 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605688
12.
Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Structure
; 24(3): 401-11, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26853940
13.
Structural basis of Keap1 interactions with Nrf2.
Free Radic Biol Med
; 88(Pt B): 101-107, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26057936
14.
Structure-activity relationship refinement and further assessment of indole-3-glyoxylamides as a lead series against prion disease.
ChemMedChem
; 6(1): 115-30, 2011 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21154498
15.
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.
Eur J Med Chem
; 46(9): 4125-32, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21726921
16.
Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein.
J Pharm Biomed Anal
; 52(5): 802-8, 2010 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20376913
17.
Improved 2,4-diarylthiazole-based antiprion agents: switching the sense of the amide group at C5 leads to an increase in potency.
ChemMedChem
; 5(9): 1476-88, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20635376