[Efficacy of reamberin for the treatment of acute intestinal infections caused by opportunistic bacteria].

Reamberin was shown to improve the efficacy of the treatment of acute intestinal infections caused by opportunistic bacteria. Its introduction into combined therapy accelerated normalization of the patients' general conditions, improved their well-being, eliminated syndrome of infectious toxicosis, diarrheic and abdominal pain syndromes, decreased duration of postinfectious asthenia, had beneficial effect on biochemical and immune parameters. Reamberin reduced the level of medium-sized molecules and malonic dialdehyde to the upper normal value which suggests elimination of endogenous "metabolic" intoxication syndrome, normalization of the level of circulating immune complexes and their fractional composition. The study showed that introduction of reamberin in combined therapy of acute intestinal infections is pathogenetically justified.

[Estimation of clinical-pathogenetic efficiency of reamberin and cycloferon application in patients with the severe form of acute tonsillitis].

Efficiency of reamberin and cycloferon application combination at the patients with the heavy form of acute tonsillitis was investigated. It is set that cycloferon and reamberin application in the complex of treatment of the patients with this pathology is instrumental in normalization of the general state and feel of patients, liquidation of both commontoxic syndrome and local inflammatory displays in pharynx, and also normalization of the studied biochemical and immunological indexes. Application of cycloferon and reamberin provides the decline of "average molecules" and malon dialdehyde level to norm, that testifies about liquidation endogenous "metabolic" intoxication syndrome, and also instrumental in normalization of phagocytes activity of monocytes indexes, that describe normalize operating of the indicated preparation on the macrophage phagocytes system.

[Clinical efficiency of reamberin - cycloferon combination in treatment of hepatic cirrhosis associated with chronic HCV infection].

The clinical efficiency of a reamberin and cycloferon combination for the treatment of hepatic cirrhosis (HC) associated with chronic HCV infection has been studied. Immunological investigation of patients carried out before the treatment revealed a significant increase in the level of proinflammatory cytokines (CK) in serum, whereas the level of anti-inflammatory CK changed rather insignificantly. Use of the reamberin - cycloferon combination provided faster clinical-biochemical remission and, in respect of the pathogenetic state, ensured normalization of the CK profile in the blood. Based on these data, it can be considered as pathogenetically proved and clinically feasible and promising to use the reamberin - cycloferon combinations for a complex treatment of patients with HC associated with chronic HCV-infection.

[Efficacy of combined immunocorrection in the treatment of chronic viral hepatitis C].

AIM: To assess efficacy of combined immunocorrection in the treatment of patients with chronic viral hepatitis C (CVHC). MATERIAL AND METHODS: Routine clinicobiochemical tests, examination of immunological homeostasis (cellular immunity, the level of circulating immune complexes - CIC and their molecular composition, macrophagal phagocyting system - MPS) were made in two groups of CVHC patients: the study group (n=68) and control group (n=66). The control patients received standard treatment, the study group received also cyclopheron in combination with reamberin. Cyclopheron was given per os in a single daily dose 600 mg 2 days, then 3 times a week in a dose 150 mg for 48 weeks. Reamberin infusions in a single daily dose 400 ml were made for 5 - 7 days. RESULTS: CVHC in exacerbation phase is characterized by the presence of secondary immunodeficiency running with T-lymphopenia, low count of peripheral blood lymphocytes with CD4+ phenotype and low immunoregulatory index CD4/CD8, depression of functional activity of T-cells as evidenced by lymphocyte blast transformation test with phytohemagglutinin, inhibition of phagocyting activity of monocytes and inhibition of dermal macrophages. This shows subnormal functional activity of MPS. CVHC runs with accumulation of CIC in blood serum primarily due to increased content of most pathogenic mid- and low-molecular .ifactions of immune complexes. Addition ofcyclopheron and reamberin in combined treatment of CVHC patients promotes normalization of immunological homeostasis which clinically occurs in parallel with achievement of persistent and long-term CVHC remission. CONCLUSION: The results of the above investigation support pathogenetic validity and prospects of cyclopheron and reamberin inclusion into combined treatment of CVHC.

[Influence of immunotropic preparation cycloferon and phytopreparations of Cynara scolimus L. on blood cytokines profile of the patients with chronic viral hepatitis C in medical rehabilitation period].

The effect of the immunotropic drug cycloferon and herbal medicine resources on the basis of Cynara scolimus L. on the blood cytokine profile in the patients with chronic viral hepatitis C (CVHC) in medical rehabilitation (MR) period. Established that prior to MR period in the patients with CVHC was noted significantly increased levels of proinflammatory cytokines (CK) at the blood serum, and the level of antiinflammatory CK changed significantly. The use of cycloferon and herbal medicine resources on the basis of Cynara scolimus L. in the MR complex provided to normalize the studied CK concentration in the serum of the patients with CVHC.

[Efficiency of enterosorbent White Coal in the treatment of the patients with chronic viral hepatitis C and its influence on lipoperoxidation markers and endogenous intoxication in blood of patients].

Efficiency of enterosorbent White Coal (aerosil) at the treatment of the patients with chronic viral hepatitis C (CVHC) was investigated. It was set that including of enterosorbent White Coal (aerosil) to the complex treatment of the patients with CVHC provided more fast liqudation clinical symptoms and provided archievment of clinical-biochemical remission and at pathogenetic plan--decrease of concentration "average molecules" and lipoperoxidation's products in the serum that testified about liqudation "metabolic intoxication" and oxidative stress syndromes.

[Efficiency of enterosorbent white coal* in the treatment of patients with hepatic cirrhosis].

Efficiency of enterosorbent White Coal (aerosil) at the treatment of the patients with hepatic cirrhosis (HC) was investigated. It was set that including of enterosorbent White Coal to the complex treatment of the patients with HC provided more fast liqudation clinical symptoms and provided archievment of clinical-biochemical remission and at pathogenetic plan - decrease of concentration "average molecules", lipoperoxidation's products, increase of antioxydant system enzymes in the serum that testified about liqudation "metabolic intoxication" and oxidative stress syndromes.

[Efficiency of modern immunoactive preparation cycloferon at coplex therapy of the patients with nonalcoholic steatohepatitis combined with irritable bowel syndrome].

The efficiency of modern immunoactive preparation cycloferon at coplex therapy of the patients with nonalcoholic steatohepatitis (NASH) combined with irritable bowel syndrome (IBS). It was set that before treatment took place devition of immune homeostasis such as cellular immunity and serum interferon activity. Application of cycloferon provided to regress of clinical symptoms of NASH, combined with IBS and normalization of immune indexes.

[Effectivity of detoxification preparation reamberin in complex treatment of the patients with chronic cholecystitis combined with chronic pancreatitis on background of HCV-infection].

Effectivity of detoxic preparation reamberin at complex treatment of the patients with acuting of chronic cholecystitis combined with chronic pancreatitis on background of HCV-infection was detected. It was set that before treatment took place increase "average molecules", lipid peroxidation products--malondialdehyde and dien conjugates and increase of circulatory immune complexes in serum. Including of reamberin provided to normalization clinical-biochemical indexes.

[Using amyzon in the treatment of patients with sore throat]. / Primenenie amizona v lechenii bol'nykh anginoi.

Presented in the paper is experience gained with the use of a new Ukrainian drug amyzon in treating angina. Administration of amyzon in adult patients with angina was noted to make for a quicker eradication of the infectious toxicosis syndrome and manifestations of local inflammation, normalization of the peripheral blood picture and indices for immunologic homeostasis. With amyzon complications develop less frequently. Angina patients when placed on amyzon tend to run a shorter course of their illness and achieve long-term clinical remission, which fact permits recommending its use in a complex therapy of angina in adult patients.

[The cytogenetic indices of participants in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station and their correction]. / Tsitogeneticheskie pokazateli u uchastnikov likvidatsii posledstvii avarii na ChAES i ikh korrektsiia.

An analysis was performed of cytogenetic homeostasis in liquidators of the Chernobyl accident after-effects, which led to the belief that if the above contingent of subjects continue living in large industrial regions characterized by high levels of environmental contamination with industrial waste, such as that formed in the chemical, by-product coke, and metallurgical industries, they will not dispel disorders of the cytogenetic homeostasis (chromosomal and chromatic aberrations), which fact is believed to be due to the inhibition of the processes of elimination of somatic cells with a faulty genotype. Proposed for the correction of cytogenetic disorders are such options as a complex of antioxidants and intravascular laser irradiation of blood, that will, we believe, help in restoring the cytogenetic homeostasis.