Detalhe da pesquisa
1.
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
J Med Chem
; 67(2): 1262-1313, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38180485
2.
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.
J Med Chem
; 64(5): 2534-2575, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596065
3.
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
J Med Chem
; 64(5): 2576-2607, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596073
4.
Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates.
J Med Chem
; 63(17): 9603-9622, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787101
5.
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J Med Chem
; 61(3): 989-1000, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227683
6.
Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors.
ACS Med Chem Lett
; 8(10): 1037-1041, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29057047
7.
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.
Nat Chem
; 8(12): 1112-1119, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27874860
8.
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1914-31, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24195700
9.
Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.
J Med Chem
; 57(19): 7890-9, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25191794