Pesquisa | BVS Violência e Saúde

1.

Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.

Maclean, Kenneth N; Jiang, Hua; Phinney, Whitney N; Mclagan, Bailey M; Roede, James R; Stabler, Sally P.

Mol Genet Metab ; 132(2): 128-138, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33483253

2.

Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA.

Fiddler, Joanna L; Xiu, Yuwen; Blum, Jamie E; Lamarre, Simon G; Phinney, Whitney N; Stabler, Sally P; Brosnan, Margaret E; Brosnan, John T; Thalacker-Mercer, Anna E; Field, Martha S.

J Nutr ; 151(10): 2882-2893, 2021 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-34383924

3.

Alterations in Sulfur Amino Acids as Biomarkers of Disease.

Stabler, Sally P.

J Nutr ; 150(Suppl 1): 2532S-2537S, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-33000156

4.

p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid-Nonresponsive Neural Tube Defects in Mice.

Lachenauer, Erica R; Stabler, Sally P; Field, Martha S; Stover, Patrick J.

J Nutr ; 150(7): 1705-1712, 2020 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-32271909

5.

Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ß-synthase-deficient homocystinuria.

Maclean, Kenneth N; Jiang, Hua; Phinney, Whitney N; Keating, Amy K; Hurt, K Joseph; Stabler, Sally P.

FASEB J ; 33(5): 6339-6353, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30768359

6.

Maternal Amino Acid Profiles to Distinguish Constitutionally Small versus Growth-Restricted Fetuses Defined by Doppler Ultrasound: A Pilot Study.

Porter, Anne C; Gumina, Diane L; Armstrong, Michael; Maclean, Kenneth N; Reisdorph, Nichole; Galan, Henry L; Stabler, Sally P; Bailey, Beth A; Hobbins, John C; Hurt, K Joseph.

Am J Perinatol ; 37(11): 1084-1093, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32120425

7.

Taurine treatment prevents derangement of the hepatic Î³-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.

Maclean, Kenneth N; Jiang, Hua; Aivazidis, Stefanos; Kim, Eugene; Shearn, Colin T; Harris, Peter S; Petersen, Dennis R; Allen, Robert H; Stabler, Sally P; Roede, James R.

FASEB J ; 32(3): 1265-1280, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29101223

8.

Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.

Van Hove, Johan L K; Freehauf, Cynthia L; Ficicioglu, Can; Pena, Loren D M; Moreau, Kerrie L; Henthorn, Thomas K; Christians, Uwe; Jiang, Hua; Cowan, Tina M; Young, Sarah P; Hite, Michelle; Friederich, Marisa W; Stabler, Sally P; Spector, Elaine B; Kronquist, Kathryn E; Thomas, Janet A; Emmett, Peggy; Harrington, Mary J; Pyle, Laura; Creadon-Swindell, Geralyn; Wempe, Michael F; MacLean, Kenneth N.

J Inherit Metab Dis ; 42(3): 424-437, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30873612

9.

Folate Deficiency Facilitates Genomic Integration of Human Papillomavirus Type 16 DNA In Vivo in a Novel Mouse Model for Rapid Oncogenic Transformation of Human Keratinocytes.

Xiao, Suhong; Tang, Ying-Sheng; Kusumanchi, Praveen; Stabler, Sally P; Zhang, Ying; Antony, Asok C.

J Nutr ; 148(3): 389-400, 2018 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-29546304

10.

Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.

Jacobs, René L; Jiang, Hua; Kennelly, John P; Orlicky, David J; Allen, Robert H; Stabler, Sally P; Maclean, Kenneth N.

Mol Genet Metab ; 120(4): 325-336, 2017 04.

Artigo em Inglês | MEDLINE | ID: mdl-28291718

11.

Identification of ABC transporters acting in vitamin B₁₂ metabolism in Caenorhabditis elegans.

McDonald, Megan K; Fritz, Julie-Anne; Jia, Dongxin; Scheuchner, Deborah; Snyder, Floyd F; Stanislaus, Avalyn; Curle, Jared; Li, Liang; Stabler, Sally P; Allen, Robert H; Mains, Paul E; Gravel, Roy A.

Mol Genet Metab ; 122(4): 160-171, 2017 12.

Artigo em Inglês | MEDLINE | ID: mdl-29153845

12.

Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells.

Tang, Ying-Sheng; Khan, Rehana A; Xiao, Suhong; Hansen, Deborah K; Stabler, Sally P; Kusumanchi, Praveen; Jayaram, Hiremagalur N; Antony, Asok C.

J Nutr ; 147(4): 482-498, 2017 04.

Artigo em Inglês | MEDLINE | ID: mdl-28250194

13.

Molecular and biochemical investigations of patients with intermediate or severe hyperhomocysteinemia.

Sørensen, Jannie Tanderup; Gaustadnes, Mette; Stabler, Sally P; Allen, Robert H; Mudd, S Harvey; Hvas, Anne-Mette.

Mol Genet Metab ; 117(3): 344-50, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26750749

14.

Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression.

Quintana, Anita M; Geiger, Elizabeth A; Achilly, Nate; Rosenblatt, David S; Maclean, Kenneth N; Stabler, Sally P; Artinger, Kristin B; Appel, Bruce; Shaikh, Tamim H.

Dev Biol ; 396(1): 94-106, 2014 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-25281006

15.

Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes.

Bae, Sajin; West, Allyson A; Yan, Jian; Jiang, Xinyin; Perry, Cydne A; Malysheva, Olga; Stabler, Sally P; Allen, Robert H; Caudill, Marie A.

J Nutr ; 145(7): 1507-14, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-25995278

16.

Altered hepatic sulfur metabolism in cystathionine ß-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways.

Jiang, Hua; Stabler, Sally P; Allen, Robert H; Abman, Steven H; Maclean, Kenneth N.

FASEB J ; 28(9): 4044-54, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-24891521

17.

Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo.

Xiao, Suhong; Tang, Ying-Sheng; Khan, Rehana A; Zhang, Yonghua; Kusumanchi, Praveen; Stabler, Sally P; Jayaram, Hiremagalur N; Antony, Asok C.

J Biol Chem ; 287(15): 12559-77, 2012 Apr 06.

Artigo em Inglês | MEDLINE | ID: mdl-22351779

18.

Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.

Maclean, Kenneth N; Greiner, Lori S; Evans, Jeffrey R; Sood, Sudesh K; Lhotak, Sarka; Markham, Neil E; Stabler, Sally P; Allen, Robert H; Austin, Richard C; Balasubramaniam, Vivek; Jiang, Hua.

J Biol Chem ; 287(38): 31994-2005, 2012 Sep 14.

Artigo em Inglês | MEDLINE | ID: mdl-22854956

19.

Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.

Abarinov, Elena V; Beaudin, Anna E; Field, Martha S; Perry, Cheryll A; Allen, Robert H; Stabler, Sally P; Stover, Patrick J.

J Nutr ; 143(7): 1028-35, 2013 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23700346

20.

Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.

Field, Martha S; Shields, Kelsey S; Abarinov, Elena V; Malysheva, Olga V; Allen, Robert H; Stabler, Sally P; Ash, Jessica A; Strupp, Barbara J; Stover, Patrick J; Caudill, Marie A.

J Nutr ; 143(1): 41-5, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23190757

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