[Behavior of Zn-phosphate cement in parafunctional conditions. 2. Wear resistance of Zn-phosphate cement]. / Ponasanje Zn-fosfat cementa u uslovima parafunkcionih aktivnosti. II deo: Otpornost na habanje Zn-fosfat cementa.

The paper deals with the phenomenon of complex stress of the Zn-phosphate cement when slope specimens are loaded. In a 5 degree slope the horizontal component was only 0.7% whereas this value began to increase up to 45.3% when the slope was 40 degrees. It is of interest that in the slant specimens the significant part of the total force referred to horizontal component, particularly expressed in parafunctions, which speaks for the unfavourable stress type suffered by specimen slope. The second part of the experiment revealed the degree of wear of Zn-phosphate cement parafunctional activities. The value of 1800 which presents the number of contacts realized by a patient with parafunctions only in the course of daily action of occlusive dental surfaces, was selected as the maximal number of pulses. The following was established: with the increase of pulses the degree of wear was also increased; the wear was more expressed in the mobile specimen; the degree of wear of the mobile specimen was not a linear function of the number of pulses contrary to the fixed one in which a linear dependence was observed.

[The effect of angiotensin I converting enzyme inhibitors on renal function indicators in hypertensive patients]. / Uticaj inhibitora konvertujuceg enzima angiotenzina-I na funkcijske pokazatelje bubrega u hipertenzivnih bolesnika.

The paper reviews the results of a preliminary study on hemodynamic and functional kidney indices in patients with hypertension with different etiopathogenesis. The investigation was carried out in 36 patients; 30 cases with no renal artery stenosis (RAS) and 6 cases with different stages of RAS. The investigation was conducted both in basal conditions and after the peroral administration of captopril (Zorcaptil à 25 mg, 1h before the examination). Kidney hemodynamics and its function were investigated by the dynamic kidney scintigraphy with the deconvolution analysis of the renogram and by the determination of the total and separate clearances 99Tcm-MAG3 and/or 99Tcm-DTPA. The obtained results lead to the conclusion that the sensitivity of the applied methodology enables differentiation of hypertensions in whose etiopathogenesis the renin-angiotensin-aldosterone system (RAAS) does not play the key role. Further investigations are needed for valid conclusions to be made.

Short-term effects of captopril (Katopil) on renal haemodynamics and function in hypertensive patients.

Short-term effects of captopril on the renal-hemodynamics and function were evaluated in 75 adult hypertensive patients. The behaviour of total and divided effective renal plasma flows (ERPF) and parenchymal mean transit time (PaMTT) implied three types of effect the premedication exerted on local renal haemodynamics and function: a protective one, no significant changes and an adverse one. In the vast majority of the cases captopril induced reduction in systemic blood pressure, was observed, irrespective of the renal response. The methodology presented seems to be a sensitive test for the selection of patients in whom an overall beneficial effect from the therapy with captopril monotherapy is expected.

Effects of nonsteroidal antiinflammatory drugs on renal plasma flow and glomerular filtration rate in patients with glomerulonephritis.

We investigated the effects of NSAIDs (Ibuprofen) on renal plasma flow (RPF) and glomerular filtration rate (GFR) in patients with glomerulonephritis. The study included 98 patients (53 men and 45 women) with idiopathic glomerulonephritis. All of the patients received Ibuprofen 1200 mg (3x400) during 7 days. Before and after the treatment with Ibuprofen ERPF (clearance of 131I-Hippuran) and GFR (clearance of 99mTc-DTPA) were determined. In our patients administration of Ibuprofen was associated with a significant reduction in renal plasma flow and glomerular filtration rate. In patients with reduced renal function the decrease in RPF and GFR after Ibuprofen was significantly greater than in patients with normal renal function.

[The importance of beta-2 microglobulin determination in the urine in the detection of tubular proteinuria]. / Znacaj odredivanja beta-2 mikroglobulina u urinu u detekciji proteinurije tubulskog tipa.

In 38 patients with the positive finding of protein in the urine the determination of beta-2 microglobulin concentration was made in addition to the simultaneous determination of albumin, IgC and transfer in the urine and the calculation of differential protein clearance values for the identification of tubular proteinuria. Only 4 (10.53%) patients had proteinuria of tubular type, 16 patients had proteinuria of glomerular type, while proteinuria of the mixed glomerulo-tubular type was found in 18 (47.37%) patients. The safe separation of tubular proteinuria from that of glomerular type was made possible by the determination of beta-2 microglobulin concentration in the urine in the framework of detailed investigation.

[Anti-proteinuria effects of nonsteroidal anti-inflammatory drugs in patients with nephrotic syndrome: an illusion or a read improvement?]. / Antiproteinuricni efekat nesteroidnih antiinflamacionih lekova u bolesnika s nefrotskim sindromom: privid ili stvarno poboljsanje?

In order to examine the antiproteinuric effect of non-steroidal antiinflammatory drugs in patients with nephrotic syndrome, we performed a parallel determination of the daily proteinuria, strength of glomerular filtration and of the effective renal plasmatic flow in basal conditions and after a 7 day ibuprofen therapy at a daily dose of 1200mg (3 x 400mg) in a group of 12 patients with idiopathic glomerulonephritis. In all patients ibuprofen therapy induced a significant decrease of the existing proteinuria, but this decrease was accompanied by the decrease of clearance rate of 99mTc-DTPA and 131J-hipuran clearance, that is by decrease of strength of glomerular filtration (averagely 24.29%) and effective renal plasmatic flow (averagely 18.74%). It can be concluded that the decrease of proteinuria in patients with nephrotic syndrome after ibuprofen therapy (as well as other non-steroidal antiinflammatory drugs) is primarily the result of worsening of hemodynamic conditions in the kidney, that it is caused by the reduction of the renal blood flow and by the strength of glomerular filtration in conditions of cycloxygenetic activity inhibition in the kidney.

[Radionuclide functional tests in transplanted kidneys]. / Radionuklidno funkcijsko ispitivanje transplantiranog bubrega.

Results of 140 combined first-pass and dynamic functional renal studies were clinically evaluated in 50 patients with a transplanted kidney. The renal handling of three different nephroaffine radionuclides, namely the glomerular agent (99m Tc-DTPA), the predominantly tubular agent (99m TcMAG3) and combined glomerulo-tubular agent (99m Tc-PAHIDA) was also analysed in various dysfunctions of renal transplants. It has been concluded, that the clinically most useful information at all levels of the overall renal function has been given by 99m TcMAG3. However, the behaviour of glomerular and tubular agents in postischaemic acute tubular lesion was found to be discordant which in turn could be valuable differential-diagnostic information, and out of this reason their successive application is essential. The combined firstpass and dynamic functional renal studies have been judged as a helpful diagnostic tool in the follow-up of patients who have undergone kidney transplantation, provided that its results are interpreted in the light of clinical and other relevant findings.