RESUMO
BACKGROUND/PURPOSE: Emergency department (ED) overcrowding is a universal problem, especially with the shortage of hospital beds. We studied the characteristics and outcomes of patients with prolonged ED stays, which has rarely been studied before. METHODS: We conducted a retrospective study at a tertiary medical center in Taiwan. Prolonged stay in the ED was defined as a stay of more than 72 hours in the ED before admission. The medical records were reviewed for data analysis. RESULTS: From November 1, 2009 to January 31, 2010, a total of 1364 general medical patients were enrolled. The mean age was 66.4 ± 17.8 years, with 53.4% male. The mean Charlson Comorbidity Index (CCI) was 3.0 ± 3.1. The mean length of ED stay was 43.9 ± 41.0 hours. The CCI (4.1 ± 3.5 vs. 2.8 ± 3.0, p < 0.001) and do-not-resuscitate (DNR) rates (18.8% vs. 10.3%, p = 0.001) of the patients with prolonged ED stays were higher than those of the patients with shorter stays. For patients with high CCI (≥3) and DNR consent, the odds ratio of prolonged ED stay was 1.73 and 1.60, respectively. Patients with prolonged ED stays also had a lower Barthel index (60.3 ± 34.8 vs. 66.4, p = 0.011) and higher in-hospital mortality (11.6% vs. 6.0%, p = 0.006). CONCLUSION: Complex comorbidities and terminal conditions with DNR consent were associated with the prolonged ED stay for general medical patients. The hospital manager should pay attention to general medical patients with multiple comorbidities as well as those who require palliative care.
Assuntos
Serviço Hospitalar de Emergência/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Admissão do Paciente/estatística & dados numéricos , Tempo para o Tratamento , Idoso , Idoso de 80 Anos ou mais , Comorbidade , Feminino , Mortalidade Hospitalar , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Estudos Retrospectivos , Taiwan , Centros de Atenção TerciáriaRESUMO
BACKGROUND: Case reports have indicated that a tropical cyclone may increase Emergency Department (ED) visits significantly. STUDY OBJECTIVES: To examine emergency health care demands across a series of tropical cyclones, and to build a predictive model to analyze a cyclone's potential effect. METHODS: This was an observational non-concurrent prospective study performed in Taiwan. Twenty hospitals were included. The number of daily ED visits in each hospital was our primary end point, and data were retrieved from the database provided by the National Health Insurance Research Database. Our study examined the period from 2000 to 2008. A total of 22 tropical cyclones (typhoons) that had passed over eastern Taiwan and covered the area under study were included. Multiple linear regression time-series models were employed to estimate the effects of "days since typhoon landfall" and various characteristics of the typhoons on the end point of daily ED visits to each hospital. RESULTS: The final multiple linear regression time-series model showed that the number of daily ED visits increased in areas where a strong typhoon had landed directly, with the increase being evident during the first 2 days since landfall. Our model also indicated that the three most important variables to predict a change in the pattern of daily ED visits were intensity of typhoon, simultaneous heavy rain, and direct landfall. CONCLUSIONS: During tropical cyclones, emergency services were under increased demand in selected time periods and areas. Health care authorities should collect information to build local models to optimize their resources allocation in preparation.
Assuntos
Tempestades Ciclônicas , Serviço Hospitalar de Emergência/estatística & dados numéricos , Necessidades e Demandas de Serviços de Saúde/estatística & dados numéricos , Adolescente , Adulto , Idoso , Tempestades Ciclônicas/classificação , Bases de Dados Factuais , Feminino , Humanos , Modelos Lineares , Masculino , Transtornos Mentais/terapia , Pessoa de Meia-Idade , Estudos Prospectivos , Chuva , Dermatopatias/terapia , Taiwan , Ferimentos e Lesões/terapia , Adulto JovemRESUMO
OBJECTIVE: To investigate the reasons for the occurrence of clinically significant adverse events (CSAEs) in emergency department-discharged patients through emergency physicians' (EPs) subjective reasoning and senior EPs' objective evaluation. DESIGN: This was a combined prospective follow-up and retrospective review of cases of consecutive adult non-traumatic patients who presented to a tertiary-care emergency department in Taiwan between 1 September 2005 and 31 July 2006. Data were extracted from 'on-duty EPs' subjective reasoning for discharging patients with CSAEs (study group) and without CSAEs (control group)' and 'objective evaluation of CSAEs by senior EPs, using clinical evidences such as recording history, physical examinations, laboratory/radiological examinations and observation of inadequacies in the basic management process (such as recording history, physical examinations, laboratory/radiological examinations and observation) as the guide'. Subjective reasons for discharging patients' improvement of symptoms, and the certainty of safety of the discharge were compared in the two groups using χ(2) statistics or t test. RESULTS: Of the 20,512 discharged cases, there were 1370 return visits (6.7%, 95% CI 6.3% to 7%) and 165 CSAEs due to physicians' factors (0.82%, 95% CI 0.75% to 0.95%). In comparisons between the study group and the control group, only some components of discharge reasoning showed a significant difference (p<0.001). Inadequacies in the basic management process were the main cause of CSAEs (164/165). CONCLUSION: The authors recommended that EP follow-up of the basic management processes (including history record, physical examination, laboratory and radiological examinations, clinical symptoms/signs and treatment) using clinical evidence as a guideline should be made mandatory.
Assuntos
Continuidade da Assistência ao Paciente/normas , Serviço Hospitalar de Emergência/normas , Erros Médicos , Alta do Paciente/tendências , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Progressão da Doença , Feminino , Seguimentos , Humanos , Entrevistas como Assunto , Masculino , Estudos Prospectivos , Estudos Retrospectivos , Risco , Medição de Risco , Taiwan/epidemiologiaRESUMO
The purpose of this report is to describe the use of telecommunication to improve the quality of postoperative care following microsurgery, especially following microvascular transfer of intestinal transfer for which shortening of ischemia time is of utmost importance to achieve high success rate. From 2003 to 2009 microvascular transfer of intestinal flaps had been performed in 112 patients. After surgery the patients were put in intensive care unit and the flaps were checked every 1 hour. The image for circulatory status of the flaps was sent directly to the attending surgeon for judgment. The information was sent through intranet and the surgeon can get access to the intranet through internet if necessary. Among the 112 cases, there were 9 cases of reexploration. The average duration between the time of problem detection and the time of starting reexploration was 54 min in 7 cases, and other 2 cases were delayed to enter the operating room which had been occupied by other cases of major trauma. Only two flaps were lost completely, two patients developed narrowing at the junction of cervical esophagus and thoracic esophagus. The rate of salvage for intestinal flap is apparently higher than those reported in the literature. In the postoperative management of microsurgery in ICU, telecommunication can help to reduce the ischemia time after vascular compromise in the transfer of free intestinal flap. Telecommunication is really an easy and effective tool in improving the outcome of reconstructive surgery.
Assuntos
Retalhos de Tecido Biológico/irrigação sanguínea , Intestinos/transplante , Microcirurgia/métodos , Cuidados Pós-Operatórios/métodos , Telecomunicações , Adulto , Idoso , Estudos de Coortes , Diagnóstico Precoce , Feminino , Rejeição de Enxerto , Humanos , Neoplasias Hipofaríngeas/cirurgia , Intestinos/cirurgia , Isquemia/prevenção & controle , Isquemia/terapia , Masculino , Microcirurgia/efeitos adversos , Pessoa de Meia-Idade , Monitorização Fisiológica/métodos , Melhoria de Qualidade , Procedimentos de Cirurgia Plástica/efeitos adversos , Procedimentos de Cirurgia Plástica/métodos , Estudos Retrospectivos , Medição de Risco , Neoplasias da Glândula Tireoide/cirurgia , Fatores de Tempo , Resultado do Tratamento , Gravação em VídeoRESUMO
Medical tourism is a new trend in medical service. It is booming not only in Asian countries but also in European and South American countries. Worldwide competition of medical service is expected in the future, and niche service will be a "trademark" for the promotion of global medicine. Niche service also functions for market segmentation. Niche services are usually surgical procedures. A study was carried out to compare different strategies for developing medical tourism in Asian countries. The role of a niche service is evaluated in the initiation and further development of medical tourism for individual countries. From this study, a general classification was proposed in terms of treatment procedures. It can be used as a useful guideline for additional studies in medical tourism. Niche service plays the following roles in the development of medical tourism: (1) It attracts attention in the mass media and helps in subsequent promotion of business, (2) it exerts pressure on the hospital, which must improve the quality of health care provided in treating foreign patients, especially the niche services, and (3) it is a tool for setting up the business model. E-Da Hospital is an example for developing medical tourism in Taiwan. A side effect is that niche service brings additional foreign patients, which will contribute to the benefit of the hospital, but this leaves less room for treating domestic patients. A niche service is a means of introduction for entry into the market of medical tourism. How to create a successful story is important for the development of a niche service. When a good reputation has been established, the information provided on the Internet can last for a long time and can spread internationally to form a distinguished mark for further development. Niche services can be classified into 3 categories: (1) Low-risk procedures with large price differences and long stay after retirement; (2) high-risk procedures with less of a price difference, and (3) banned procedures that are not allowed legally in home countries of foreign patients, such as stem cell therapy. In establishing a niche service, a high-quality, nonmedical segment should be integrated as well.
Assuntos
Turismo Médico/classificação , Desenvolvimento de Programas , Sudeste Asiático , Atenção à Saúde/organização & administração , Competição Econômica , Humanos , Internet , Turismo Médico/economia , Avaliação de Resultados em Cuidados de Saúde , RiscoRESUMO
Entry lesions at the toes interdigital spaces, in the setting of chronic lymphedema, are strongly associated with repetitive infective episodes which cause significant morbidity. A prospective study was designed to evaluate the outcome in 2 groups of patients affected by end stage III lymphedema of the lower extremity, treated with the Charles procedure with or without simultaneous amputation of the toes. At a mean 3 years of follow-up, 20% of the patients receiving elective toes amputation experienced recurrence of the infection and none required more proximal amputations. Among the patients not desiring elective toes amputation; 83% suffered multiples attacks of cellulitis and in 88% the toes were eventually amputated. The difference in the number of infective episodes between the 2 groups was highly significant. No cases of recurrent lymphedema were registered. Elective toes amputation in combination with the Charles procedure reduces recurrent cellulitis and long-term morbidity in stage III lymphedema of the lower leg.
Assuntos
Amputação Cirúrgica/métodos , Celulite (Flegmão)/cirurgia , Linfedema/cirurgia , Dedos do Pé/cirurgia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Recidiva , Reoperação , Resultado do TratamentoRESUMO
OBJECTIVE: A National Thalassemia Screening Program was adopted in Taiwan in 1993. This report examined that program's results and impact. METHODS: Patients with beta-thalassemia major born between 1994 and 2003 were recruited through the help of all thalassemia clinics in Taiwan. A structured questionnaire was designed to collect the reasons for affected births. RESULTS: There were 97 affected births from 1994 to 2003.These births resulted after informed choice (n = 4), screening problems (n = 83), and undetermined causes (n = 10). Approximately 83% (5/6) of affected births in 2003 came from interracial marriages. CONCLUSIONS: This report has identified several areas that might improve the thalassemia-screening program, including carrier screening in high school rather than in early pregnancy and the involvement of genetic counselors, providing care of new female immigrants.
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Testes Genéticos , Diagnóstico Pré-Natal , Talassemia beta/epidemiologia , Feminino , Aconselhamento Genético , Humanos , Masculino , Grupos Raciais , Taiwan/epidemiologia , Talassemia beta/diagnósticoRESUMO
BACKGROUND: Quality of life (QOL) is now considered to be an important part of the assessment of dialysis patients. The aim of this study was to develop and assess the reliability, validity and sensitivity of the dialysis module of the World Health Organization Quality of Life - Brief (WHOQOL-BREF) Taiwan version [WHOQOL-BREF(TW)] in patients undergoing regular hemodialysis (HD). METHODS: QOL survey was administered to 283 regular HD patients in metropolitan Taipei. The instruments used included: (1) the proposed module - composed of the core part, the WHOQOL-BREF(TW), and the six specific items; (2) the symptom/problem (S/P) scale - composed of 12 items specific for dialysis patients; (3) the utility measure, which was performed with standard gamble (SG) methods; and (4) the rating scale (RS). RESULTS: Based on the six criteria of validity, reliability and variance of the items, four HD-specific items were selected. Reliability study showed that Cronbach's alphas, composite reliability, and test-retest reliability (intraclass correlation at an average retest interval of 4-8 weeks) of the four domains of physical, psychological, social relationship and environment, ranged from 0.74-0.82, 0.79-0.84 and 0.61-0.79, respectively. Validity study showed that all the correlations between an item and its corresponding domain were highly significant (r>0.4, p<0.01) and larger than the correlations between the item and other domains. SG and psychometric measures showed relatively low correlations (0.12-0.26). The module showed the same construct as the WHOQOL-BREF(TW) under confirmatory factor analysis, whereas the exploratory factor analysis showed mild variation. Convergent and discriminant validity were good. Global QOL, physical, psychological and environment domains had some sensitivity to differentiate the severity of the condition of patients receiving HD. Clinical validity was demonstrated in global QOL, physical and psychological domains to have significant correlations with S/P scores. CONCLUSION: Besides broader coverage than the core WHOQOL-BREF(TW), the dialysis module of the WHOQOL-BREF(TW) is a valid, reliable and sensitive QOL instrument for the assessment of HD patients in Taiwan.
Assuntos
Psicometria , Qualidade de Vida , Diálise Renal/psicologia , Perfil de Impacto da Doença , Adulto , Análise Fatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , TaiwanRESUMO
Objective To measure therapeutic inertia by characterizing prescription patterns using secondary data obtained from the nationwide diabetes mellitus pay-for-performance (DM-P4P) programme in Taiwan. Methods Using reimbursement claims from Taiwan's National Health Insurance Research Database, a nationwide retrospective cohort study was undertaken of patients with diabetes mellitus who participated in the DM-P4P programme from 2006-2008. Glycosylated haemoglobin results were used to evaluate modifications in therapy in response to poor diabetes control. Prescription patterns were used to assign patients to either a therapeutic inertia group or an intensified treatment group. Therapeutic inertia was defined as the failure to act on a known problem. Results The research sample comprised of 168 876 patients with diabetes mellitus who had undergone 899 135 tests. Of these, 37.4% (336 615 visits) of prescriptions were for a combination of two types of drug and 27.7% (248 788 visits) were for a combination of three types of drug. The proportion of patients in the intensified therapy group who were prescribed more than two types of drug was considerably higher than that in the therapeutic inertia group. Conclusion In many cases in the therapeutic inertia group only a single type of hypoglycaemic drug was prescribed or the dosage remained unchanged.
Assuntos
Biguanidas/uso terapêutico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Padrões de Prática Médica/estatística & dados numéricos , Sulfonamidas/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Glicemia/metabolismo , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/fisiopatologia , Feminino , Hemoglobinas Glicadas/metabolismo , Inquéritos Epidemiológicos , Humanos , Masculino , Pessoa de Meia-Idade , Programas Nacionais de Saúde , Reembolso de Incentivo/organização & administração , Estudos Retrospectivos , TaiwanRESUMO
BACKGROUND: In 1991, the World Health Organization (WHO) initiated a cross-cultural project to develop a quality-of-life (QOL) questionnaire (WHOQOL); soon after this, the clinically applicable short form was developed and named WHOQOL-BREF, followed by a Taiwanese version (WHOQOL-BREF[TW]). METHODS: We first administered the WHOQOL-BREF(TW) and symptom/problem scale to 376 patients with end-stage renal disease on regular hemodialysis therapy in Taiwan. Analysis with multiple stepwise regressions was conducted to study determinants of QOL domains and items. RESULTS: The WHOQOL-BREF(TW) was reliable and valid from various validation studies. The 4 domains (physical, psychological, social relations, and environment) and global items (overall quality of life and general health) of the WHOQOL-BREF(TW) each differentiated symptoms/problems of hemodialysis patients from age-, sex-, and education-matched healthy referents. The 4 domains, except for environment and global items of the WHOQOL-BREF(TW), each differentiated erythropoietin dosage from age-, sex-, and education-matched healthy referents. After adjusting for age, sex, marriage, and education, the prominent associated factors of various QOL domains and items were age, area (Taipei or Keelung), hemoglobin level, normalized protein catabolic rate, and symptom/problem scale. CONCLUSION: The WHOQOL-BREF(TW) is reliable and valid for long-term study of hemodialysis patients, and hemodialysis had negative impacts on QOL, especially in patients with more severe disease with greater symptom/problem scores, lower hemoglobin levels, and lower normalized protein catabolic rates.
Assuntos
Falência Renal Crônica/psicologia , Qualidade de Vida , Diálise Renal/psicologia , Inquéritos e Questionários , Adulto , Idoso , Anemia/tratamento farmacológico , Anemia/etiologia , Anemia/psicologia , Cálcio/sangue , Comorbidade , Cultura , Eritropoetina/uso terapêutico , Feminino , Hematócrito , Hemoglobinas/análise , Humanos , Falência Renal Crônica/sangue , Falência Renal Crônica/epidemiologia , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Fósforo/sangue , Reprodutibilidade dos Testes , Albumina Sérica/análise , Fatores Socioeconômicos , Taiwan/epidemiologia , Organização Mundial da SaúdeRESUMO
This article presents an analysis conducted on the patterns related to therapeutic inertia with the aim of uncovering how variables at the patient level and the healthcare provider level influence the intensification of therapy when it is clinically indicated. A cohort study was conducted on 899,135 HbA1c results from 168,876 adult diabetes patients with poorly controlled HbA1c levels. HbA1c results were used to identify variations in the prescription of hypoglycemic drugs. Logistic regression and hierarchical linear models (HLMs) were used to determine how differences among healthcare providers and patient characteristics influence therapeutic inertia. We estimated that 38.5% of the patients in this study were subject to therapeutic inertia. The odds ratio of cardiologists choosing to intensify therapy was 0.708 times that of endocrinologists. Furthermore, patients in medical centers were shown to be 1.077 times more likely to be prescribed intensified treatment than patients in primary clinics. The HLMs presented results similar to those of the logistic model. Overall, we determined that 88.92% of the variation in the application of intensified treatment was at the within-physician level. Reducing therapeutic inertia will likely require educational initiatives aimed at ensuring adherence to clinical practice guidelines in the care of diabetes patients.
Assuntos
Diabetes Mellitus/sangue , Diabetes Mellitus/tratamento farmacológico , Hemoglobinas Glicadas/análise , Hipoglicemiantes/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Diabetes Mellitus/epidemiologia , Feminino , Humanos , Modelos Lineares , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Padrões de Prática Médica , Estudos Retrospectivos , Taiwan/epidemiologia , Resultado do Tratamento , Adulto JovemRESUMO
STUDY OBJECTIVES: In the emergency medical services (EMS) system, appropriate prehospital care can substantially decrease casualty mortality and morbidity. This study designed a simulation model, evaluated the existing EMS system, and suggested improvements. METHODS: The study focused on 23 networked EMS hospitals affiliated with 36 emergency response units (subgroups) to perform two-tier rescues (advanced life support [ALS] in addition to basic life support [BLS] services) in Taipei, Taiwan. Using the existing EMS model as a base, this research constructed a computer simulation model and explored several model alternatives to achieve the study's objectives. The virtual models varied with staffing level, number of assigned emergency network hospitals, and various two-tier rescue probabilities. RESULTS: Increasing the staffing to two teams for Hospital 22 lessened the call waiting probability (delay between rescue call and ambulance dispatch) by 50%, even if the dispatch rate of the two-tier rescue increased from the empirical 2% to a simulated 10 and 20%. Changing the two-tier rescue pattern so each EMS subgroup cooperated with two specific, preassigned network hospitals lowered the probability of patients having to wait for rescue dispatch to under 1%. CONCLUSION: The following alternatives provided the greatest combination of effectiveness, quality patient care, and cost-efficiency: (1) because of its unique location, increase Hospital 22's staffing level to two ALS teams. (2) Establish a specific rescue protocol for the two-tier system that preassigns two network hospitals to each of the 36 EMS subgroups along with a prearranged calling sequence. If implemented, this will improve EMS performance, streamline the system, reduce randomness, and enhance efficiency.
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Simulação por Computador , Eficiência Organizacional/estatística & dados numéricos , Serviços Médicos de Emergência/organização & administração , Modelos Organizacionais , TaiwanRESUMO
INTRODUCTION: Improving outpatient resource utilization significantly enhances the efficiency of healthcare organizations. Substantial number of walk-in patients (average of 72% in our study) to outpatient services is a universal characteristic of Taiwan's healthcare organizations. Consequently, scheduling becomes extremely complicated and important. Selecting the right scheduling alternative, a healthcare organization can markedly improve operating efficiency of outpatient resources. OBJECTIVE: This research applied simulation methodology to analyze several scheduling solutions and found that setting the appropriate arrival time interval for preregistered patients significantly impacts queuing problems in outpatient services. METHOD: Using established simulation models, the effects of various scheduling policies on patients' throughput time and waiting times were revealed. Under alternative model A, the first 20 numbers are reserved for scheduled patients; after that, only even numbers are offered for scheduled ones. Odd numbers after 20 are left for walk-ins. Under alternative model B, front numbers were assigned to scheduled patients successively. The later numbers were left for walk-ins. Alternative model C assigned scheduled patients with even numbers and walk-ins with odd numbers in sequence. Finally, alternative model D was designed to examine the optimal scheduled time interval by conducting the model with different scheduled time intervals such as 3, 5, 7, 9, and 11 min. RESULT: The alternative sequence (alternative model C-assigning even numbers for scheduled patients and odd numbers for walk-in patients, or vice versa) significantly has the least throughput time (average: 34.9 min vs 55.2, 56.2, and 46.2 min) and waiting times (average: 14.7 min vs 34.9, 35.8, and 25.8 min) for walk-in patients compared with other registration strategies. Scheduling the appointments with flexible time interval (alternative model D) has the least throughput time (average: 24.2 min vs 28.4, 28.2, and 37.2 min) and waiting times (average: 8.0 min vs 12.5, 12.3, and 20.5 min) for scheduled patients compared with other registration strategies. CONCLUSION: The findings of this research could be applied possibly to any outpatient clinic with mixed-registration-type (walk-in and scheduled), particularly which accounts for high percentage of walk-in patients.
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Agendamento de Consultas , Sistemas de Informação Hospitalar , Hospitais Especializados/organização & administração , Modelos Organizacionais , Ambulatório Hospitalar/organização & administração , Urologia/organização & administração , Eficiência Organizacional , Humanos , Ambulatório Hospitalar/estatística & dados numéricos , Software , Design de Software , TaiwanRESUMO
BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) are widely recommended to hinder the progression of renal disease among patients with DM. However, little is known about adherence to these guidelines or the predictors of such use. METHODS: Data from the Taiwan National Health Insurance was used to investigate 7,186 DN patients, nested within 2960 randomly assigned primary care physicians in Taiwan over the course of 1 year of treatment. Patient-level variables included gender, age, and co-morbidity (i.e., coronary arterial disease, congestive heart failure, cerebrovascular disease, peripheral arterial disease, DM complications, albuminuria, anemia, hyperlipidemia, asthma, gout, and depression). Physician-level variables included work experience, the area of specialization, and the level of the physicians working in the hospital. RESULTS: We determined that 63.69% of the variation in the use of ACEIs or ARBs was at the within-physician level and 36.31% was at the between-physician level. Approximately 35.10 % of the total variation was explained by predictors related to patient characteristics. The likelihood of taking ACEIs or ARBs is significantly higher (12.92%) among male patients than females. Cardiologists and family doctors are more likely to prescribe ACEIs or ARBs in of doctors working in medical centers. CONCLUSIONS: Management of DN patients is less than optimal due to unfamiliarity on the part of physicians regarding treatment guidelines and a lack of awareness among the general population with regard to DN. Educational initiatives are required to ensure adherence to clinical practice guidelines in the evaluation and care of DN patients.
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Anti-Hipertensivos/uso terapêutico , Nefropatias Diabéticas/tratamento farmacológico , Fidelidade a Diretrizes/estatística & dados numéricos , Hipertensão/tratamento farmacológico , Adesão à Medicação/estatística & dados numéricos , Médicos de Atenção Primária , Idoso , Análise de Variância , Antagonistas de Receptores de Angiotensina/uso terapêutico , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Nefropatias Diabéticas/complicações , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Hipertensão/complicações , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Médicos de Atenção Primária/educação , Médicos de Atenção Primária/normas , Guias de Prática Clínica como Assunto , TaiwanRESUMO
To compare the diagnostic accuracy of various cardiovascular screening tools in asymptomatic subjects with intermediate-to-high risk Framingham risk score (FRS). In addition, we also investigated whether carotid artery study could further add incremental value beyond metabolic abnormality and inflammatory marker in this issue. 1,200 asymptomatic subjects who underwent health evaluation were recruited in our study. FRS was calculated in all participants based on clinical variables, body surface electrocardiography, medical histories, and life styles. Metabolic scores, serum high-sensitivity C reactive protein (hs-CRP) level and carotid artery study in assessing intima-media-thickness (CIMT) and plaque were all obtained and compared to FRS. Comparison of diagnostic accuracy was then conducted among these different tools aiming at a more efficient screen in identifying intermediate-to-high FRS. Of all, 1,101 participants (mean age 50.6 ± 10.4, 38.6 % women) were finally entered in our study after exclusion of known cardiovascular diseases. By utilizing common carotid IMT (CCIMT) equal or larger than 1 mm, best specificity (98.27, 95 % CI 97.24-98.99) was achieved in identifying intermediate-to-high FRS subject. The most optimal cut-off in identifying intermediate-to-high FRS for metabolic scores, hs-CRP and CCIMT was 2, 0.101 mg/dL and 0.65 mm, respectively. Both receiver operating characteristic curve and likelihood ratio tests showed that information provided by carotid artery study further showed significant incremental value when superimposed on metabolic scores and hs-CRP (all p < 0.05) in screening intermediate-to-high FRS subjects. Though diagnostic accuracy may differ to some degree by using different cut-off values, a low metabolic score seemed to have the best sensitivity with abnormal CCIMT yielded highest specificity in screening a subject with future cardiovascular risks. Carotid artery study added significant clinical incremental value in discriminating projected risk beyond metabolic scores and hs-CRP.
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Proteína C-Reativa/análise , Doenças das Artérias Carótidas/diagnóstico , Artéria Carótida Primitiva/diagnóstico por imagem , Espessura Intima-Media Carotídea , Mediadores da Inflamação/sangue , Programas de Rastreamento/métodos , Adulto , Idoso , Área Sob a Curva , Doenças Assintomáticas , Biomarcadores/sangue , Doenças das Artérias Carótidas/sangue , Doenças das Artérias Carótidas/diagnóstico por imagem , Distribuição de Qui-Quadrado , Estudos Transversais , Feminino , Humanos , Funções Verossimilhança , Masculino , Pessoa de Meia-Idade , Placa Aterosclerótica , Valor Preditivo dos Testes , Curva ROC , Medição de Risco , Fatores de Risco , TaiwanRESUMO
This study used data mining techniques to investigate disease forms in various administrative areas and to analyze the differences among various administrative areas in order to further draw up a disease distribution map. It is hoped that may help formulate future public health strategies and to allocate medical resources more appropriately. The major disease forms for residents under the age of 60 were hypertension, hyperglycemia and hyperlipidemia. In regard to the neighboring areas, three neighboring areas, A1, A3, and B9, shared the same disease problems with A4, A5, and B3, while two mountain-area cities, B7 and C10, experienced higher instances of liver function impairment. In terms of the clustering phenomenon among municipally graded administrative areas, the major health problems in Grade A cities were hypertension, hyperglycemia, and hyperlipidemia. The health problems such as liver function impairment and renal dysfunction were more frequently observed in Grade B and Grade C cities.
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Mineração de Dados , Métodos Epidemiológicos , Programas de Rastreamento , Vigilância da População/métodos , Desenvolvimento de Programas , Adulto , Idoso , Análise por Conglomerados , Feminino , Humanos , Hipercolesterolemia/embriologia , Hiperlipidemias/epidemiologia , Hepatopatias/enzimologia , Masculino , Pessoa de Meia-Idade , Insuficiência Renal/embriologia , Taiwan/epidemiologiaRESUMO
OBJECTIVES: National guidelines recommend angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) therapy for diabetic patients with hypertension and/or proteinuria to hinder renal disease progression. However, little is known about the adequacy of adherence to these guidelines in diabetic patients and about the predictors of such appropriate ACEIs or ARBs use. We sought to define the rates of ACEIs and ARBs use in a large population of patients with diabetic nephropathy (DN). METHODS: Using linked medical claims from the National Health Insurance Research Database, we studied a cohort of patients with DN. We used multivariate logistic regression to measure the predictors of usage of the agents studied. RESULTS: Of the 7159 DN patients studied, 5564 patients (77.7%) had hypertension. Of these, only 50.6% were administered ACEIs or ARBs during the quarter studied. In multivariate analyses, greater rates for usage of ACEIs or ARBs were found in patients with coronary artery disease or congestive heart failure. CONCLUSIONS: Only 50% of the patients with DN received the recommended treatment with ACEIs or ARBs. This shortfall provides an opportunity for quality-improvement interventions that could provide beneficial clinical outcomes for these high-risk patients.
Assuntos
Angiotensina II/uso terapêutico , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Nefropatias Diabéticas/tratamento farmacológico , Padrões de Prática Médica/estatística & dados numéricos , Vasoconstritores/uso terapêutico , Idoso , Angiotensina II/administração & dosagem , Inibidores da Enzima Conversora de Angiotensina/administração & dosagem , Estudos de Coortes , Bases de Dados como Assunto , Progressão da Doença , Feminino , Fidelidade a Diretrizes , Humanos , Hipertensão/complicações , Hipertensão/tratamento farmacológico , Hipertensão/etiologia , Masculino , Pessoa de Meia-Idade , Proteinúria/complicações , Proteinúria/tratamento farmacológico , Proteinúria/etiologia , Taiwan , Vasoconstritores/administração & dosagemRESUMO
BACKGROUND: Advances in treatment have improved the prognosis in beta-thalassemia major. We present the survival and complications pattern of those patients in northern Taiwan born after 1970. PROCEDURE: One-hundred and sixty patients with beta-thalassemia major born after 1970 were collected. The Kaplan-Meier method and log-rank test were used to estimate and compare survival. Cox regression models were used to examine the associations of bone marrow transplantation (BMT), time of BMT procedure, and time of complications with survival. RESULTS: Better survival was observed for patients born after 1980 (P = 0.0121). Heart disease, BMT-related deaths, and infections were the main causes of death. Among the living patients over age 15, hypogonadotropic hypogonadism, HCV infection, diabetes, heart failure, and arrhythmia were the common complications. No patients under age 15 had complications. CONCLUSIONS: Survival for patients with beta-thalassemia major has improved significantly in Taiwan. More time is required to demonstrate whether these modalities added to the treatment of these patients will impact favorably on their outcome. Our success with BMT is improving and we are now in a position to offer this curative alternative.
Assuntos
Talassemia beta/complicações , Talassemia beta/mortalidade , Adolescente , Adulto , Arritmias Cardíacas/complicações , Transplante de Medula Óssea , Causas de Morte , Criança , Pré-Escolar , Complicações do Diabetes , Feminino , Cardiopatias/complicações , Insuficiência Cardíaca/complicações , Hepatite C/complicações , Humanos , Hipogonadismo/complicações , Lactente , Recém-Nascido , Infecções/complicações , Masculino , Prognóstico , Taxa de Sobrevida , Taiwan/epidemiologia , Talassemia beta/terapiaRESUMO
Emergency medical service (EMS) policy makers must seek to achieve maximum effectiveness with finite resources. This research establishes an EMS computer simulation model using eM-Plant software. The simulation model is based on Taipei city's EMS system with input data from prehospital care records from December 2000; it manipulates resource allocation levels and rates of idle errands. Presently, EMS ambulance utilization is about 8.78%. On average, 20.89 minutes are required to transport a patient to the hospital. Computer simulations showed that reducing the number of ambulances to one at each of the 36 response units increases the utilization rate to 15.47% but does not compromise the current service quality level. Thus, ambulance utilization improves, times of patients waiting for pre-hospital care and arrival at hospitals are only slightly affected, and considerable cost savings result. This study provides a research methodology and suggests specific policy directions for resource allocation in EMS. Limiting the number of ambulances to one per response unit reduces costs, increases efficiency, and yet maintains the same operational pattern of medical service.