Detalhe da pesquisa
1.
Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement.
Cell
; 186(21): 4528-4545.e18, 2023 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37788669
2.
Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness.
J Biol Chem
; 299(6): 104825, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37196766
3.
Construction of an IMiD-based azide library as a kit for PROTAC research.
Org Biomol Chem
; 19(1): 166-170, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33226388
4.
Nickel-Catalyzed [2+2+2] Cycloaddition of Alkyne-Nitriles with Alkynes Assisted by Lewis Acids: Efficient Synthesis of Fused Pyridines.
Chemistry
; 22(47): 16765-16769, 2016 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27643803
5.
Zirconium-mediated multicomponent reactions of 1,3-butadiynes with ylidenemalononitriles to form functionalized 1,8-naphthyridine and cyclopenta[b]pyridine derivatives.
Chemistry
; 21(4): 1420-4, 2015 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25470360
6.
Design, synthesis and biological evaluation of novel quinazolinone derivatives as CRBN E3 ligase modulators.
Eur J Med Chem
; 247: 115016, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36577219
7.
Aryne [3 + 2] cycloaddition with N-sulfonylpyridinium imides and in situ generated N-sulfonylisoquinolinium imides: a potential route to pyrido[1,2-b]indazoles and indazolo[3,2-a]isoquinolines.
Org Biomol Chem
; 10(9): 1922-30, 2012 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22278679
8.
Reactive oxygen species-responsive Pre-PROTAC for tumor-specific protein degradation.
Chem Commun (Camb)
; 58(72): 10072-10075, 2022 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35993284
9.
The PROTAC selectively degrading Bcl-xL represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth.
Theranostics
; 12(17): 7476-7490, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36438482
10.
DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs.
Nat Commun
; 13(1): 7133, 2022 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36414666
11.
Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile.
J Med Chem
; 64(13): 9152-9165, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138566
12.
Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J Med Chem
; 62(20): 9281-9298, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31539241
13.
Cp2TiCl2-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic amines.
Chem Commun (Camb)
; 51(29): 6426-9, 2015 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25765939