[PRACTICAL AND FUNCTIONAL RESEARCH OF THE INTERACTION OF LEVELS OF PUBLIC AUTHORITY IN FEDERAL STATES IN THE CONTEXT OF THE NEW CORONAVIRUS INFECTION (COVID-19) PANDEMIC: ASSESSMENTS AND PROSPECTS].

The objectives of this research are to explore foreign experience of interaction of various levels of public authority in federal states in the context of the COVID-19 pandemic, to determine the prospects for the development and improvement of the activities of the public authority system in Russia in this part. MATERIALS AND METHODS: The regulatory legal acts and the practice of interaction of various levels of public authority during the COVID-19 pandemic in federations (Australia, India, Canada, USA) were research. RESULTS: It has been established that a dual federal system with strict rules for the distribution of powers and responsibilities between the federation and its regions impedes a coordinated national response in the fight against the COVID-19 pandemic, while various forms of executive federalism serve as the key to successfully countering this threat. The latter can be based on historically strong centralist tendencies, the existing negotiating practices of interaction between the executive branch at all levels, the experience of implementing federal programs and the work of emergency intergovernmental mechanisms. CONCLUSIONS: It has been substantiated that the optimal organization of managerial decision-making in the context of countering a pandemic presupposes a complex interagency approach with a strong federal presence.

[Analysis of the development of acute coronary syndrome during the COVID-19 pandemic].

The study compares two groups of patients with acute coronary syndrome, depending on the presence of COVID-19 in the anamnesis. The comparison groups analyzed the risk factors for cardiovascular diseases, including smoking, heredity, gender differences, age, diabetes, and obesity. The results of biochemical blood tests were analyzed. It was found that patients with acute coronary syndrome who underwent COVID-19 were less likely to have risk factors for cardiovascular diseases. Patients with acute coronary syndrome who underwent COVID-19 were found to have lower blood glucose, cholesterol, very-low-density lipoprotein, and triglycerides. As a result of the study, it was revealed that COVID-19 is an independent risk factor for the development of acute coronary syndrome.

[ORGANIZATION OF MEDICAL REHABILITATION OF PATIENTS WITH COVID-19 IN THE POST-HOSPITAL PERIOD].

The COVID-19 pandemic poses new challenges for the health sector, related to the organization of medical rehabilitation of patients with COVID-19. Special attention is required for patients after artificial ventilation, who have a high risk of developing physical, mental and cognitive disorders. There are acute post-ovoid syndrome lasting more than 3 weeks and chronic-lasting more than 12 weeks after discharge from the hospital. The most common symptoms are: shortness of breath, fatigue, anosmia, ageusia, myalgia, feeling of fever, tightness in the chest, tachycardia, headaches, anxiety, memory loss, sleep disorders, difficulty concentrating. The article presents the stages of rehabilitation of patients with COVID-19. Dynamic monitoring, measures for the prevention of complications, organization and methods of rehabilitation, including physiotherapy procedures and physical therapy, are considered.

Conceptual principles and patterns of legal regulation of the processes of storage, access and data protection of genome sequencing in foreign countries as the basis for the modernization of Russian legislation.

The relevance of the study of the general principles and patterns of legal regulation of access storage processes and data protection of genome sequencing in foreign countries is determined by the need to develop a general concept of legal regulation of this type of activity in Russia. The purpose of this study is to develop the system-forming principles and patterns of access storage and data protection of genome sequencing in Russia. To achieve this goal, tasks were set and solved to identify and study the general principles and patterns of legal regulation of access storage processes and data protection of genome sequencing in foreign countries. The international documents regulating the features of regulation of access storage processes and data protection of genome-wide sequencing, the doctrinal sources of Great Britain, the USA, France, Israel, and Japan are studied. Methods used: general philosophical, general scientific, private scientific, special (structural-legal, comparative-legal, formal-legal). The general principles for the formation of the concept of legal regulation of genome sequencing in Russia are proposed. It was revealed that the creation of a universal regulatory regulator aimed at protecting the subject of personal data in view of the prevalence of public interests over private ones and the constant expansion of the scope of application of genetic data obtained as a result of genome-wide sequencing is the main problem in developing a legal regulation mechanism in the studied area. For the first time, the authors determine the basic principles for developing the concept of genome-wide sequencing in Russia, including: recognition of human rights and human dignity as the highest value, the necessity of researchers' responsibility for the well-being of participants in view of the obtained research results, the mandatory informed consent of which should be voluntary, permanent, their right to get acquainted with the results obtained if it concerns their health, access to such information, ensuring the right to non-knowledge of research results and others.

[Ethical boundaries of the legal regulation of genome sequencing in Russia and abroad.] / Этические границы правового регулирования полногеномного секвенирования в России и за рубежом.

The relevance of the chosen topic is due to the need to resolve ethical problems that arise in the framework of legal regulation of genome-wide sequencing in Russia and foreign countries. The purpose of this research is to form ethical principles that should become a reference point for law - making in this area. In order to achieve this goal, we have solved the tasks of studying the normative legal acts of Russia and a number of foreign countries from an ethical point of view. General scientific, private scientific and special methods of scientific knowledge (system-structural, formal-legal) are used. In order to comply with the ethical boundaries of legal regulation, to store access and protect full-genome sequencing data in Russia and foreign countries, it is proposed to develop a set of restrictions that prevent possible discrimination on genetic grounds, to create the necessary conditions for the inadmissibility of disclosure of personalized data, disclosure of information about a genetic disease to the subject and his relatives, as well as the boundaries of editing the genome of a human embryo. For the first time, the authors substantiate the need to establish clear ethical boundaries in the implementation of genome-wide sequencing in Russia based on foreign experience.

[Storage, access and protection of full genome sequencing data in Russia and foreign countries: practical aspect.]

The relevance of the chosen topic is due to the need to resolve legal problems in the field of observance of human and civil rights and freedoms when storing, accessing and protecting full genome sequencing data. The purpose of this study is the formation of conceptual criteria on the basis of which a new model of regulatory regulation of this sphere of public relations will be built. To achieve this goal, the tasks of studying the regulatory legal acts in force in Russia and a number of foreign countries were solved. General scientific, private-scientific and special methods of scientific knowledge (system-structural, formal-legal) were used. In order to formulate conceptual criteria of practical importance for storing access and protecting genome-wide sequencing data in Russia and foreign countries, it was proposed to develop clarifying characteristics or gradation of human and civil rights and freedoms in the context of realization of public state interests. It is also necessary to unify the content of the conceptual apparatus of normative acts taking into account the peculiarities of genetic information, work out the procedure for accessing data, and provide for a system of its depersonification. For the first time, the authors substantiate the need to transform the content of the human rights declared by the state to life, freedom, personal and family secrets, and others with the development of new technologies in the field of DNA scanning. The basic criteria that are of practical importance for the storage, access and protection of genome-wide sequencing data indicate the need to improve normative concepts, establish categories of persons with the right to access such data, normatively fix the conditions for observing an anonymous survey, and also refuse to get acquainted with the results , to develop mechanisms for the depersonification of the obtained genetic information).

[Pathological changes in the tissues of the helminth Thominx phasianina after the single administration of tetramisole]. / Patologicheskie izmeneniia tkanei gel'minta Thominx phasianina posle odnokratnogo vvedeniia tetramizola.

A single dose (0.2 g/kg) of 20% tetramisole granulate to pheasants infected with Thominx phasianina resulted in intestinal helminth elimination in 72 hours. Structural injuries of the helminth cutaneomuscular sac, digestive and sexual system were detected, manifesting 6 h after the injection and reaching their peak 24 h after it. The mitochondria and endoplasmic reticulum of middle intestinal wall, uterus, oviduct epitheliocytes, oogonia, and oocytes of nematodes were found the most sensitive to the drug.