Pesquisa | BVS Violência e Saúde

1.

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.

Di Marcantonio, Daniela; Martinez, Esteban; Kanefsky, Joice S; Huhn, Jacklyn M; Gabbasov, Rashid; Gupta, Anushk; Krais, John J; Peri, Suraj; Tan, YinFei; Skorski, Tomasz; Dorrance, Adrienne; Garzon, Ramiro; Goldman, Aaron R; Tang, Hsin-Yao; Johnson, Neil; Sykes, Stephen M.

Mol Cell ; 81(13): 2752-2764.e6, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-34081901

2.

BRCA1 Mutational Complementation Induces Synthetic Viability.

Nacson, Joseph; Di Marcantonio, Daniela; Wang, Yifan; Bernhardy, Andrea J; Clausen, Emma; Hua, Xiang; Cai, Kathy Q; Martinez, Esteban; Feng, Wanjuan; Callén, Elsa; Wu, Wei; Gupta, Gaorav P; Testa, Joseph R; Nussenzweig, André; Sykes, Stephen M; Johnson, Neil.

Mol Cell ; 78(5): 951-959.e6, 2020 06 04.

Artigo em Inglês | MEDLINE | ID: mdl-32359443

3.

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.

Sykes, Stephen M; Lane, Steven W; Bullinger, Lars; Kalaitzidis, Demetrios; Yusuf, Rushdia; Saez, Borja; Ferraro, Francesca; Mercier, Francois; Singh, Harshabad; Brumme, Kristina M; Acharya, Sanket S; Scholl, Claudia; Schöll, Claudia; Tothova, Zuzana; Attar, Eyal C; Fröhling, Stefan; DePinho, Ronald A; Armstrong, Scott A; Gilliland, D Gary; Scadden, David T.

Cell ; 146(5): 697-708, 2011 Sep 02.

Artigo em Inglês | MEDLINE | ID: mdl-21884932

4.

Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death.

Kanefsky, Joice; Basse, Mary; Sokei, Judith; di Martino, Orsola; Valin, Liana; Jaspers, Yorrick; Martinez, Esteban; Huhn, Jacklyn; Di Marcantonio, Daniela; Magee, Jeffrey A; Goldman, Aaron R; Tang, Hsin-Yao; Ferraro, Francesca; Kemp, Stephan; Wiest, David L; Sykes, Stephen M.

J Biol Chem ; 300(5): 107214, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38522521

5.

The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22.

Stanek, Timothy J; Gennaro, Victoria J; Tracewell, Mason A; Di Marcantonio, Daniela; Pauley, Kristen L; Butt, Sabrina; McNair, Christopher; Wang, Feng; Kossenkov, Andrew V; Knudsen, Karen E; Butt, Tauseef; Sykes, Stephen M; McMahon, Steven B.

EMBO J ; 40(16): e102509, 2021 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-34155658

6.

DNA polymerase Î¸ protects leukemia cells from metabolically induced DNA damage.

Vekariya, Umeshkumar; Toma, Monika; Nieborowska-Skorska, Margaret; Le, Bac Viet; Caron, Marie-Christine; Kukuyan, Anna-Mariya; Sullivan-Reed, Katherine; Podszywalow-Bartnicka, Paulina; Chitrala, Kumaraswamy N; Atkins, Jessica; Drzewiecka, Malgorzata; Feng, Wanjuan; Chan, Joe; Chatla, Srinivas; Golovine, Konstantin; Jelinek, Jaroslav; Sliwinski, Tomasz; Ghosh, Jayashri; Matlawska-Wasowska, Ksenia; Chandramouly, Gurushankar; Nejati, Reza; Wasik, Mariusz; Sykes, Stephen M; Piwocka, Katarzyna; Hadzijusufovic, Emir; Valent, Peter; Pomerantz, Richard T; Morton, George; Childers, Wayne; Zhao, Huaqing; Paietta, Elisabeth M; Levine, Ross L; Tallman, Martin S; Fernandez, Hugo F; Litzow, Mark R; Gupta, Gaorav P; Masson, Jean-Yves; Skorski, Tomasz.

Blood ; 141(19): 2372-2389, 2023 05 11.

Artigo em Inglês | MEDLINE | ID: mdl-36580665

7.

The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm.

Zhang, Yong; Truong, Billy; Fahl, Shawn P; Martinez, Esteban; Cai, Kathy Q; Al-Saleem, Essel D; Gong, Yulan; Liebermann, Dan A; Soboloff, Jonathan; Dunbrack, Roland; Levine, Ross L; Fletcher, Steven; Kappes, Dietmar; Sykes, Stephen M; Shapiro, Paul; Wiest, David L.

Blood ; 140(4): 359-373, 2022 07 28.

Artigo em Inglês | MEDLINE | ID: mdl-35436326

8.

Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.

Maifrede, Silvia; Nieborowska-Skorska, Margaret; Sullivan-Reed, Katherine; Dasgupta, Yashodhara; Podszywalow-Bartnicka, Paulina; Le, Bac Viet; Solecka, Martyna; Lian, Zhaorui; Belyaeva, Elizaveta A; Nersesyan, Alina; Machnicki, Marcin M; Toma, Monika; Chatain, Nicolas; Rydzanicz, Malgorzata; Zhao, Huaqing; Jelinek, Jaroslav; Piwocka, Katarzyna; Sliwinski, Tomasz; Stoklosa, Tomasz; Ploski, Rafal; Fischer, Thomas; Sykes, Stephen M; Koschmieder, Steffen; Bullinger, Lars; Valent, Peter; Wasik, Mariusz A; Huang, Jian; Skorski, Tomasz.

Blood ; 132(1): 67-77, 2018 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-29784639

9.

mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.

Limon, Jose J; So, Lomon; Jellbauer, Stefan; Chiu, Honyin; Corado, Juana; Sykes, Stephen M; Raffatellu, Manuela; Fruman, David A.

Proc Natl Acad Sci U S A ; 111(47): E5076-85, 2014 Nov 25.

Artigo em Inglês | MEDLINE | ID: mdl-25385646

10.

NCAM1 supports therapy resistance and LSC function in AML.

Sykes, Stephen M.

Blood ; 133(21): 2247-2248, 2019 05 23.

Artigo em Inglês | MEDLINE | ID: mdl-31122937

11.

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.

Saez, Borja; Ferraro, Francesca; Yusuf, Rushdia Z; Cook, Colleen M; Yu, Vionnie W C; Pardo-Saganta, Ana; Sykes, Stephen M; Palchaudhuri, Rahul; Schajnovitz, Amir; Lotinun, Sutada; Lymperi, Stefania; Mendez-Ferrer, Simon; Toro, Raquel Del; Day, Robyn; Vasic, Radovan; Acharya, Sanket S; Baron, Roland; Lin, Charles P; Yamaguchi, Yu; Wagers, Amy J; Scadden, David T.

Blood ; 124(19): 2937-47, 2014 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-25202142

12.

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.

Placke, Theresa; Faber, Katrin; Nonami, Atsushi; Putwain, Sarah L; Salih, Helmut R; Heidel, Florian H; Krämer, Alwin; Root, David E; Barbie, David A; Krivtsov, Andrei V; Armstrong, Scott A; Hahn, William C; Huntly, Brian J; Sykes, Stephen M; Milsom, Michael D; Scholl, Claudia; Fröhling, Stefan.

Blood ; 124(1): 13-23, 2014 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-24764564

13.

Proplatelet generation in the mouse requires PKCÎµ-dependent RhoA inhibition.

Gobbi, Giuliana; Mirandola, Prisco; Carubbi, Cecilia; Masselli, Elena; Sykes, Stephen M; Ferraro, Francesca; Nouvenne, Antonio; Thon, Jonathan N; Italiano, Joseph E; Vitale, Marco.

Blood ; 122(7): 1305-11, 2013 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-23838351

14.

Missense mutations in Myc Box I influence nucleocytoplasmic transport to promote leukemogenesis.

Arthur, Nancy Bj; Christensen, Keegan A; Mannino, Kathleen; Ruzinova, Marianna B; Kumar, Ashutosh; Gruszczynska, Agata; Day, Ryan B; Erdmann-Gilmore, Petra; Mi, Yiling; Sprung, Robert; York, Conner R; Townsend, R Reid; Spencer, David H; Sykes, Stephen M; Ferraro, Francesca.

Clin Cancer Res ; 2024 Jun 07.

Artigo em Inglês | MEDLINE | ID: mdl-38848040

15.

Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.

He, Fan; Laranjeira, Angelo Ba; Kong, Tim; Lin, Shuyang; Ashworth, Katrina J; Liu, Alice; Lasky, Nina M; Fisher, Daniel Ac; Cox, Maggie J; Fulbright, Mary C; Antunes-Heck, Lilian; Yu, LaYow; Brakhane, Molly; Gao, Bei; Sykes, Stephen M; D'Alessandro, Angelo; Di Paola, Jorge; Oh, Stephen T.

J Clin Invest ; 134(3)2024 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-38060311

16.

The identity crisis of Hif-1α in HSC biology.

Sykes, Stephen M.

Blood ; 127(23): 2782-4, 2016 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-27282941

17.

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.

Cornejo, Melanie G; Mabialah, Vinciane; Sykes, Stephen M; Khandan, Tulasi; Lo Celso, Cristina; Lopez, Cécile K; Rivera-Muñoz, Paola; Rameau, Philippe; Tothova, Zuzana; Aster, Jon C; DePinho, Ronald A; Scadden, David T; Gilliland, D Gary; Mercher, Thomas.

Blood ; 118(5): 1264-73, 2011 Aug 04.

Artigo em Inglês | MEDLINE | ID: mdl-21653327

18.

Differential niche and Wnt requirements during acute myeloid leukemia progression.

Lane, Steven W; Wang, Yingzi J; Lo Celso, Cristina; Ragu, Christine; Bullinger, Lars; Sykes, Stephen M; Ferraro, Francesca; Shterental, Sebastian; Lin, Charles P; Gilliland, D Gary; Scadden, David T; Armstrong, Scott A; Williams, David A.

Blood ; 118(10): 2849-56, 2011 Sep 08.

Artigo em Inglês | MEDLINE | ID: mdl-21765021

19.

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis.

Arthur, Nancy Bj; Christensen, Keegan A; Mannino, Kathleen; Ruzinova, Marianna B; Kumar, Ashutosh; Gruszczynska, Agata; Day, Ryan B; Erdmann-Gilmore, Petra; Mi, Yiling; Sprung, Robert; York, Conner R; Reid Townsend, R; Spencer, David H; Sykes, Stephen M; Ferraro, Francesca.

bioRxiv ; 2023 Oct 23.

Artigo em Inglês | MEDLINE | ID: mdl-37961226

20.

Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis.

Mellert, Hestia S; Stanek, Timothy J; Sykes, Stephen M; Rauscher, Frank J; Schultz, David C; McMahon, Steven B.

J Biol Chem ; 286(6): 4264-70, 2011 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-21148320

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