Detalhe da pesquisa
1.
Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule.
Bioorg Med Chem Lett
; 105: 129759, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38636717
2.
Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity.
Bioorg Med Chem
; 98: 117579, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38168630
3.
Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells.
Bioorg Med Chem
; 100: 117632, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38340642
4.
A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1.
Chem Pharm Bull (Tokyo)
; 72(2): 155-160, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38296557
5.
Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning.
Chem Pharm Bull (Tokyo)
; 72(2): 173-178, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38296560
6.
Site-selective modification strategies in antibody-drug conjugates.
Chem Soc Rev
; 50(2): 1305-1353, 2021 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33290462
7.
Identification of Novel Histone Deacetylase 6-Selective Inhibitors Bearing 3,3,3-Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group.
Chembiochem
; 22(22): 3158-3163, 2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34224197
8.
Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation.
J Med Chem
; 66(22): 15171-15188, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37847303
9.
Recent progress on small molecules targeting epigenetic complexes.
Curr Opin Chem Biol
; 67: 102130, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35240380
10.
Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC).
Chem Commun (Camb)
; 58(29): 4635-4638, 2022 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35311871
11.
Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates.
ACS Med Chem Lett
; 13(10): 1568-1573, 2022 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36262394
12.
Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach.
J Med Chem
; 64(21): 15810-15824, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34727689
13.
Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library.
Nat Commun
; 11(1): 4935, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33004797