Detalhe da pesquisa
1.
Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists.
Bioorg Med Chem
; 26(9): 2229-2250, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29459145
2.
Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg Med Chem
; 26(3): 647-660, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29291937
3.
Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors.
Bioorg Med Chem Lett
; 27(11): 2497-2501, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400232
4.
Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
Bioorg Med Chem
; 25(17): 4876-4886, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760529
5.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).
Bioorg Med Chem
; 24(14): 3192-206, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255179
6.
Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.
Bioorg Med Chem
; 24(11): 2466-75, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117263
7.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.
Bioorg Med Chem Lett
; 25(19): 4245-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26298496
8.
Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aß42 production.
Bioorg Med Chem
; 23(9): 1923-34, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25842363
9.
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
J Med Chem
; 64(6): 3059-3074, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33682410
10.
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.
J Med Chem
; 58(9): 3892-909, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25897973
11.
Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.
J Med Chem
; 54(12): 4207-18, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568291
12.
1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT2-selective agonists.
J Med Chem
; 54(9): 3436-44, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21473625