[A novel disposable circumcision device versus conventional surgery in the treatment of redundant prepuce and phimosis].

OBJECTIVE: To compare the clinical effect of a novel disposable circumcision device Ring with that of conventional circumcision in the treatment of redundant prepuce and phimosis. METHODS: Totally, 750 patients with redundant prepuce or phimosis underwent Ring circumcision (group A, n = 450) or conventional circumcision (group B, n = 300). We recorded the operation time, intraoperative blood loss, Visual Analogue Scale (VAS) intraoperative pain scores, postoperative complications, wound healing time, and patients' satisfaction with postoperative penile appearance, followed by comparison of the collected data between the two groups of patients. RESULTS: All the operations were successfully completed. Group A, as compared with B, showed significantly shorter operation time (ï¼»3.78 ± 0.42ï¼½ vs ï¼»26.24 ± 3.99ï¼½ min, P <0.05), less intraoperative blood loss (ï¼»2.39 ± 1.01ï¼½ vs ï¼»10.80 ± 3.57ï¼½ ml, P <0.05), lower pain scores intraoperatively (0.14 ± 0.36 vs 2.30 ± 1.46, P <0.05), 6 hours postoperatively (0.32 ± 0.78 vs 3.03 ± 1.56, P <0.05) and at the ring removal (3.35 ± 1.42 vs 2.78 ± 1.43, P <0.05), shorter wound healing time (ï¼»7.61 ± 1.60ï¼½ vs ï¼»8.57 ± 1.37ï¼½ d, P <0.05), higher satisfaction with postoperative penile appearance (97.8% ï¼»440/450ï¼½ vs 86% ï¼»258/300ï¼½, P <0.05), and lower incidence of postoperative bleeding or hematoma (0.89% ï¼»4/450ï¼½ vs 3% ï¼»9/300ï¼½, P <0.05). No statistically significant differences were observed between groups A and B in the nocturnal pain score before the ring removal (1.45±1.02 vs 1.38 ± 0.92, P >0.05) or the postoperative incidence rate of edema (0.89% ï¼»4/450ï¼½ vs 2.33% ï¼»7/300ï¼½, P >0.05). There were no significant postoperative infections or delayed incision healing except for 1 case of wound dehiscence in each group. CONCLUSIONS: Ring circumcision, with its advantages of shorter operation time, less blood loss and pain, higher safety, and better postoperative penile appearance, is easily accepted by the patients and deserves wide clinical application.

[A novel disposable ring versus the suture device in circumcision].

OBJECTIVE: To investigate the clinical effect of a novel disposable ring versus that of the suture device in circumcision for redundant prepuce and phimosis. METHODS: We randomly assigned 470 male patients with redundant prepuce or phimosis to receive circumcision with a novel disposable ring (the DR group, n = 235) or the suture device (the SD group, n = 235) and compared the operation time, intraoperative blood loss, pain scores, wound healing time, and postoperative complications and penile appearance between the two groups of patients. RESULTS: All the operations were completed smoothly. Compared with the SD group, the DR group showed significantly shorter operation time (ï¼»7.49 ± 1.84ï¼½ vs ï¼»3.83 ± 0.42ï¼½ min, P <0. 05), less intraoperative blood loss (ï¼»3.34 ± 2.59ï¼½ vs ï¼»2.41 ± 1.01ï¼½ ml, P <0.05), lower intraoperative pain score (0.57 ± 0.76 vs 0.20 ± 0.47, P <0.05) and 6-hour postoperative pain score (3.42 ± 1.12 vs 0.48 ± 0.94, P <0.05), shorter wound healing time (ï¼»12.05 ± 2.80ï¼½ vs ï¼»7.79 ± 1.65ï¼½ d, P <0.05), lower incidence rates of postoperative glans congestion or edema (36.17% ï¼»85/235ï¼½ vs 2.56% ï¼»6/235ï¼½, P <0.05), dysuria or strenuous urination (34.04% ï¼»80/235ï¼½ vs 2.13% ï¼»5/235ï¼½, P <0.05) and bleeding or hematoma (5.11% ï¼»12/235ï¼½ vs 1.28% ï¼»3/235ï¼½, P <0.05), and higher satisfaction with postoperative penile appearance (90.6% ï¼»213/235ï¼½ vs 95.8% ï¼»228/235ï¼½, P <0.05). There were no statistically significant differences between the SD and DR groups in the pain scores at the sixth night after operation (1.31 ± 0.96 vs 1.34 ± 1.07, P >0.05) or while the staples scraping the underpants or at the ring removal (3.49 ± 1.22 vs 3.36 ± 1.41, P >0.05). No obvious postoperative infection or delayed healing was observed except for 3 cases of wound dehiscence (1 in the DR and 2 in the SD group) and 8 cases of delayed removal of the staples in the SD group. CONCLUSIONS: The novel disposable ring, with its advantages of short operation time, less bleeding and pain, good penile appearance, high safety, and simple operation, is obviously superior to the suture device in circumcision and deserves to be applied and popularized clinically. .

[Ultrastructural changes of the rat convoluted seminiferous tubule-after alcohol consumption].

OBJECTIVE: To study the ultrastructural changes of the rat convoluted seminiferous tubule after alcohol consumption. METHODS: Forty-eight Wistar mature male rats were divided into two groups randomly: control group (A) and experimental one (B). 6 ml/(kg x d) of 50 degrees alcohol was perfused through the gastric tube for 39 days in Group B; and 6 ml/(kg x d) of normal saline was supplemented in Group A. The ultrastructure of the rat convoluted seminiferous tubule was observed by transmission electron microscope at day 14, 27 and 40. RESULTS: In Group A, the pykno-basement membrane was unstriated and uniform, Sertoli cells showed cytoplasmic profusion, with big nucleus, well-distributed nucleoplasm, distinct nucleolus, more mitochondria and plain hierarchical tight-junction. And the ultrastructure of the rat convoluted seminiferous tubule in Group B began to change at the end of the first spermatogenic cycle (D 14) and changed more and more evidently with the ethanol administration, mainly as follows: (1) more lysosomes and vacuolisation found in Sertoli cells, and organelles decreased and blurry; (2) more and bigger vacuoles among the spermatogonia, Sertoli cells and basement membrane; (3) obvious apoptosis of spermatogonia and apoptotic bodies aggregated near the membrane; (4) more cytoplasm and vacuolisation in the sperm of the convoluted seminiferous tubule, and disarranged, deleted or clustered mitochondria in the sperm tail; (5) blurry and rigid tight-junction; (6) thickened, wrinkled or broken basement membrane and under-basement CONCLUSION: Alcohol can cause ultrastructural changes of the basement membrane, tight-junction and Sertoli cells of the membrane. rat convoluted seminiferous tubule and apoptosis of spermatogonia.