Detalhe da pesquisa
1.
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Proc Natl Acad Sci U S A
; 119(36): e2206104119, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037386
2.
Structure-activity relationship studies of anti-bunyaviral cap-dependent endonuclease inhibitors.
Bioorg Med Chem Lett
; 83: 129175, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36758821
3.
Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction.
Bioorg Med Chem Lett
; 64: 128664, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35272008
4.
Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond.
Bioorg Med Chem Lett
; 33: 127742, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33316407
5.
Dihydrodibenzothiepine: Promising hydrophobic pharmacophore in the influenza cap-dependent endonuclease inhibitor.
Bioorg Med Chem Lett
; 30(22): 127547, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32927030
6.
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.
Bioorg Med Chem Lett
; 30(24): 127636, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33132115
7.
Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease.
Bioorg Med Chem Lett
; 26(19): 4739-4742, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27568084
8.
Synthesis and structure-activity relationship of p-carborane-based non-secosteroidal vitamin D analogs.
Bioorg Med Chem
; 22(4): 1227-35, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24486205
9.
New designs for HIV-1 integrase inhibitors: a patent review (2018-present).
Expert Opin Ther Pat
; 33(1): 51-66, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36750766
10.
Novel vitamin D receptor ligands bearing a spherical hydrophobic core structure--comparison of bicyclic hydrocarbon derivatives with boron cluster derivatives.
Bioorg Med Chem Lett
; 22(4): 1756-60, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22285943
11.
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.
J Med Chem
; 65(9): 6499-6512, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35352927
12.
Boron cluster-based development of potent nonsecosteroidal vitamin D receptor ligands: direct observation of hydrophobic interaction between protein surface and carborane.
J Am Chem Soc
; 133(51): 20933-41, 2011 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22066785
13.
Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease.
J Med Chem
; 62(17): 8101-8114, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31386363
14.
Identification of an intermediate in the deboronation of ortho-carborane: an adduct of ortho-carborane with two nucleophiles on one boron atom.
Chem Commun (Camb)
; (17): 2049-51, 2008 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18536817
15.
Epigenetic regulation of autophagy by the methyltransferase G9a.
Mol Cell Biol
; 33(20): 3983-93, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23918802
16.
Carbamoyl pyridone HIV-1 integrase inhibitors. 2. Bi- and tricyclic derivatives result in superior antiviral and pharmacokinetic profiles.
J Med Chem
; 56(3): 1124-35, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23316884
17.
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
J Med Chem
; 56(14): 5901-16, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845180
18.
Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore.
J Med Chem
; 55(20): 8735-44, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22963135