Pesquisa | BVS Violência e Saúde

1.

A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis.

Harrison, Stephen A; Bedossa, Pierre; Guy, Cynthia D; Schattenberg, Jörn M; Loomba, Rohit; Taub, Rebecca; Labriola, Dominic; Moussa, Sam E; Neff, Guy W; Rinella, Mary E; Anstee, Quentin M; Abdelmalek, Manal F; Younossi, Zobair; Baum, Seth J; Francque, Sven; Charlton, Michael R; Newsome, Philip N; Lanthier, Nicolas; Schiefke, Ingolf; Mangia, Alessandra; Pericàs, Juan M; Patil, Rashmee; Sanyal, Arun J; Noureddin, Mazen; Bansal, Meena B; Alkhouri, Naim; Castera, Laurent; Rudraraju, Madhavi; Ratziu, Vlad.

N Engl J Med ; 390(6): 497-509, 2024 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-38324483

2.

A Phase 3 Trial of Resmetirom in NASH with Liver Fibrosis. Reply.

Harrison, Stephen A; Taub, Rebecca.

N Engl J Med ; 390(17): 1632-1633, 2024 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-38692302

3.

Hepatic Fat Reduction Due to Resmetirom in Patients With Nonalcoholic Steatohepatitis Is Associated With Improvement of Quality of Life.

Younossi, Zobair M; Stepanova, Maria; Taub, Rebecca A; Barbone, Jordan Mark; Harrison, Stephen A.

Clin Gastroenterol Hepatol ; 20(6): 1354-1361.e7, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-34329774

4.

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Harrison, Stephen A; Bashir, Mustafa R; Guy, Cynthia D; Zhou, Rong; Moylan, Cynthia A; Frias, Juan P; Alkhouri, Naim; Bansal, Meena B; Baum, Seth; Neuschwander-Tetri, Brent A; Taub, Rebecca; Moussa, Sam E.

Lancet ; 394(10213): 2012-2024, 2019 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-31727409

5.

The effect of testosterone on ovulatory function in transmasculine individuals.

Taub, Rebecca L; Ellis, Simon Adriane; Neal-Perry, Genevieve; Magaret, Amalia S; Prager, Sarah W; Micks, Elizabeth A.

Am J Obstet Gynecol ; 223(2): 229.e1-229.e8, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32044312

6.

Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration.

Jiao, Yang; Ye, Diana Z; Li, Zhaoyu; Teta-Bissett, Monica; Peng, Yong; Taub, Rebecca; Greenbaum, Linda E; Kaestner, Klaus H.

Am J Physiol Gastrointest Liver Physiol ; 308(2): G85-91, 2015 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-25377314

7.

Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.

Gillespie, Paul; Pietranico-Cole, Sherrie; Myers, Michael; Bilotta, Joseph A; Conde-Knape, Karin; Fotouhi, Nader; Goodnow, Robert A; Guertin, Kevin R; Hamilton, Matthew M; Haynes, Nancy-Ellen; Liu, Baolian; Qi, Lida; Ren, Yonglin; Scott, Nathan R; So, Sung-Sau; Spence, Cheryl; Taub, Rebecca; Thakkar, Kshitij; Tilley, Jefferson W; Zwingelstein, Catherine.

Bioorg Med Chem Lett ; 24(12): 2707-11, 2014 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-24815509

8.

Design of the phase 3 MAESTRO clinical program to evaluate resmetirom for the treatment of nonalcoholic steatohepatitis.

Harrison, Stephen A; Ratziu, Vlad; Anstee, Quentin M; Noureddin, Mazen; Sanyal, Arun J; Schattenberg, Jörn M; Bedossa, Pierre; Bashir, Mustafa R; Schneider, David; Taub, Rebecca; Bansal, Meena; Kowdley, Kris V; Younossi, Zobair M; Loomba, Rohit.

Aliment Pharmacol Ther ; 59(1): 51-63, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37786277

9.

Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial.

Harrison, Stephen A; Taub, Rebecca; Neff, Guy W; Lucas, K Jean; Labriola, Dominic; Moussa, Sam E; Alkhouri, Naim; Bashir, Mustafa R.

Nat Med ; 29(11): 2919-2928, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37845512

10.

Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.

Yun, Weiya; Ahmad, Mushtaq; Chen, Yingsi; Gillespie, Paul; Conde-Knape, Karin; Kazmer, Sonja; Li, Shiming; Qian, Yimin; Taub, Rebecca; Wertheimer, Stanley J; Whittard, Toni; Bolin, David.

Bioorg Med Chem Lett ; 21(23): 7205-9, 2011 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-22001092

11.

Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH.

Harrison, Stephen A; Bashir, Mustafa; Moussa, Sam E; McCarty, Kevin; Pablo Frias, Juan; Taub, Rebecca; Alkhouri, Naim.

Hepatol Commun ; 5(4): 573-588, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33860116

12.

Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence.

Zelent, Bogumil; Odili, Stella; Buettger, Carol; Shiota, Chiyo; Grimsby, Joseph; Taub, Rebecca; Magnuson, Mark A; Vanderkooi, Jane M; Matschinsky, Franz M.

Biochem J ; 413(2): 269-80, 2008 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-18370929

13.

Potent, selective MCH-1 receptor antagonists.

Erickson, Shawn D; Banner, Bruce; Berthel, Steven; Conde-Knape, Karin; Falcioni, Fiorenza; Hakimi, Irina; Hennessy, Bernard; Kester, Robert F; Kim, Kyungjin; Ma, Chun; McComas, Warren; Mennona, Francis; Mischke, Steven; Orzechowski, Lucy; Qian, Yimin; Salari, Hamid; Tengi, John; Thakkar, Kshitij; Taub, Rebecca; Tilley, Jefferson W; Wang, Hong.

Bioorg Med Chem Lett ; 18(4): 1402-6, 2008 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-18243691

14.

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.

Matschinsky, Franz M; Magnuson, Mark A; Zelent, Dorothy; Jetton, Tom L; Doliba, Nicolai; Han, Yi; Taub, Rebecca; Grimsby, Joseph.

Diabetes ; 55(1): 1-12, 2006 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-16380470

15.

A glucose sensor role for glucokinase in anterior pituitary cells.

Zelent, Dorothy; Golson, Maria L; Koeberlein, Brigitte; Quintens, Roel; van Lommel, Leentje; Buettger, Carol; Weik-Collins, Heather; Taub, Rebecca; Grimsby, Joseph; Schuit, Frans; Kaestner, Klaus H; Matschinsky, Franz M.

Diabetes ; 55(7): 1923-9, 2006 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-16804059

16.

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen, Jørn V; Odili, Stella; Bjørkhaug, Lise; Zelent, Dorothy; Buettger, Carol; Kwagh, Jae; Stanley, Charles; Dahl-Jørgensen, Knut; de Beaufort, Carine; Bell, Graeme I; Han, Yi; Grimsby, Joseph; Taub, Rebecca; Molven, Anders; Søvik, Oddmund; Njølstad, Pål R; Matschinsky, Franz M.

Diabetes ; 55(6): 1713-22, 2006 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-16731834

17.

Hepatoprotection via the IL-6/Stat3 pathway.

Taub, Rebecca.

J Clin Invest ; 112(7): 978-80, 2003 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-14523032

18.

Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice.

Leu, Julia I; Crissey, Mary Ann S; Taub, Rebecca.

J Clin Invest ; 111(1): 129-39, 2003 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-12511596

19.

Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation.

Leu, Julia I; Crissey, Mary Ann S; Craig, Linden E; Taub, Rebecca.

Mol Cell Biol ; 23(4): 1251-9, 2003 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-12556485

20.

Cervical mucus and contraception: what we know and what we don't.

Han, Leo; Taub, Rebecca; Jensen, Jeffrey T.

Contraception ; 96(5): 310-321, 2017 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-28801053

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