An assessment of adverse effects of antiretroviral therapy on the development of HIV positive children by observation of dental mineralization chronology.

BACKGROUND: The difference between dental age (DA) and chronological age (CA) indicates an advance or delay in comparison with the normal standard. Considering that DA has a very close correlation with CA in a developing child, this study aimed to investigate the relationship between the effects of antiretroviral therapy on the development of HIV positive children, by observing the timing of dental mineralization. METHODS: A retrospective examination was made of the medical records and dental panoramic radiographs of 50 HIV-positive pediatric patients, aged 37-168 months of age. Through these radiographs, their DA was estimated and compared with their CA. RESULTS: The mean DA was significantly lower than the mean CA in the entire studied sample (P < 0.01). There was a statistical difference between children who received antiretroviral drugs and those who used no drugs (P = 0.02), i.e. the non-treated individuals presented practically no difference between CA and DA, while the treated patients showed a difference of 10.67 months. CONCLUSION: We conclude that the DA of HIV infected children was delayed when compared to the CA, and there was a positive association between the use of antiretroviral therapy and a delay in the chronology of dental mineralization in the sample.

Intercanine distance in the analysis of bite marks: a comparison of human and domestic dog dental arches.

One common parameter considered helpful to identify the origin of bite wounds has been the distance between the canine teeth marks left on the victim. The reliability of this parameter to differentiate the origin of the marks (human or animal) was evaluated using a sample of: a) domestic dogs (n=50) weighting between 4.9 kg and 46 kg of undefined breed and b) human beings (n=50). Dog intercanine distances (ID) were measured directly using calipers, those from the human sample were measured from wax imprints using calipers. It was found that dog bite intercanine distance measurements were overall 2.8% wider for the upper arch and 10.4% wider for the lower arch when compared with the overall result for humans. However, it was observed that the measured values for medium sized dogs (between 9.1 kg and 23.0 kg) are similar to the overall results for humans. Therefore, for this range, the stand alone use of intercanine distance measurements from bite wounds marks are inconclusive with respect of defining if of human origin.