Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34822784
2.
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Nat Commun
; 12(1): 5475, 2021 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531380
3.
Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918.
Heliyon
; 7(6): e07201, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34189291
4.
Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.
Adv Pharmacol
; 88: 35-58, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32416871
5.
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
J Med Chem
; 63(4): 1528-1543, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31860301
6.
Methodologies for the Examination of Water in GPCRs.
Methods Mol Biol
; 1705: 207-232, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29188565
7.
Potential for the Rational Design of Allosteric Modulators of Class C GPCRs.
Curr Top Med Chem
; 17(1): 71-78, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27448651
8.
The use of conformationally thermostabilised GPCRs in drug discovery: application to fragment, structure and biophysical techniques.
Curr Opin Pharmacol
; 30: 8-13, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27400445
9.
Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Nat Commun
; 12(1): 7265, 2021 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34880229
10.
Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors A Structural Perspective of Ligands and Mutants.
Sci Rep
; 5: 13869, 2015 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26359761
11.
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
J Med Chem
; 58(16): 6653-64, 2015 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26225459
12.
Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations.
Antivir Ther
; 9(2): 149-60, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15134177
13.
Molecular mapping in the CNS.
Curr Pharm Des
; 8(17): 1547-70, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12052200
14.
Structure of Class B GPCRs: new horizons for drug discovery.
Br J Pharmacol
; 171(13): 3132-45, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24628305
15.
Unifying family A GPCR theories of activation.
Pharmacol Ther
; 143(1): 51-60, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24561131
16.
A consensus neural network-based technique for discriminating soluble and poorly soluble compounds.
J Chem Inf Comput Sci
; 43(2): 674-9, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12653537