Pesquisa | BVS Violência e Saúde

1.

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.

Donovan, Katherine A; Ferguson, Fleur M; Bushman, Jonathan W; Eleuteri, Nicholas A; Bhunia, Debabrata; Ryu, SeongShick; Tan, Li; Shi, Kun; Yue, Hong; Liu, Xiaoxi; Dobrovolsky, Dennis; Jiang, Baishan; Wang, Jinhua; Hao, Mingfeng; You, Inchul; Teng, Mingxing; Liang, Yanke; Hatcher, John; Li, Zhengnian; Manz, Theresa D; Groendyke, Brian; Hu, Wanyi; Nam, Yunju; Sengupta, Sandip; Cho, Hanna; Shin, Injae; Agius, Michael P; Ghobrial, Irene M; Ma, Michelle W; Che, Jianwei; Buhrlage, Sara J; Sim, Taebo; Gray, Nathanael S; Fischer, Eric S.

Cell ; 183(6): 1714-1731.e10, 2020 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-33275901

2.

Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections.

Modukuri, Ram K; Yu, Zhifeng; Tan, Zhi; Ta, Hai Minh; Ucisik, Melek Nihan; Jin, Zhuang; Anglin, Justin L; Sharma, Kiran L; Nyshadham, Pranavanand; Li, Feng; Riehle, Kevin; Faver, John C; Duong, Kevin; Nagarajan, Sureshbabu; Simmons, Nicholas; Palmer, Stephen S; Teng, Mingxing; Young, Damian W; Yi, Joanna S; Kim, Choel; Matzuk, Martin M.

Proc Natl Acad Sci U S A ; 119(22): e2122506119, 2022 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-35622893

3.

CYP3A Mediates an Unusual C(sp²)-C(sp³) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism.

Qin, Xuan; Wang, Yong; Ye, Qiuji; Hakenjos, John M; Wang, Jin; Teng, Mingxing; Guo, Lei; Tan, Zhi; Young, Damian W; MacKenzie, Kevin R; Li, Feng.

Angew Chem Int Ed Engl ; : e202405197, 2024 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-38574245

4.

Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.

Teng, Mingxing; Jiang, Jie; Wang, Eric S; Geng, Qixiang; Toenjes, Sean T; Donovan, Katherine A; Mageed, Nada; Yue, Hong; Nowak, Radoslaw P; Wang, Jinhua; Manz, Theresa D; Fischer, Eric S; Cantley, Lewis C; Gray, Nathanael S.

Angew Chem Int Ed Engl ; 62(18): e202302364, 2023 04 24.

Artigo em Inglês | MEDLINE | ID: mdl-36898968

5.

Development of CDK2 and CDK5 Dual Degrader TMX-2172.

Teng, Mingxing; Jiang, Jie; He, Zhixiang; Kwiatkowski, Nicholas P; Donovan, Katherine A; Mills, Caitlin E; Victor, Chiara; Hatcher, John M; Fischer, Eric S; Sorger, Peter K; Zhang, Tinghu; Gray, Nathanael S.

Angew Chem Int Ed Engl ; 59(33): 13865-13870, 2020 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-32415712

6.

Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia.

Teng, Mingxing; Wu, Wentao; Li, Zhixiang; Yang, Guangwen; Qin, Jian; Wang, Yikai; Hu, Zhijing; Dong, Haiheng; Hou, Lijuan; Hu, Guoping; Shen, Liang; Zhang, Yang; Li, Jian; Chen, Shuhui; Tian, Jingwei; Ye, Liang; Zhang, Jianzhao; Wang, Hongbo.

Bioorg Med Chem Lett ; 27(22): 4979-4984, 2017 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-29037948

7.

The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia.

Wu, Wentao; Li, Zhixiang; Yang, Guangwen; Teng, Mingxing; Qin, Jian; Hu, Zhijing; Hou, Lijuan; Shen, Liang; Dong, Haiheng; Zhang, Yang; Li, Jian; Chen, Shuhui; Tian, Jingwei; Zhang, Jianzhao; Ye, Liang.

Bioorg Med Chem Lett ; 27(10): 2210-2215, 2017 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-28385504

8.

Total synthesis of the monoterpenoid indole alkaloid (±)-aspidophylline A.

Teng, Mingxing; Zi, Weiwei; Ma, Dawei.

Angew Chem Int Ed Engl ; 53(7): 1814-7, 2014 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-24481917

9.

[Antitumor effect of capsaicin on colorectal carcinoma xenograft in nude mice].

Zhu, Li-li; Hu, Wan-le; Zhang, Lin-jun; Yu, Zhi-gao; Huang, Chong-jie; Jiang, Ming-zhe; Teng, Ming-xing; Liu, Jian-lu; Liu, Chang-bao.

Zhonghua Zhong Liu Za Zhi ; 35(4): 256-61, 2013 Apr.

Artigo em Zh | MEDLINE | ID: mdl-23985252

10.

The rise of degrader drugs.

Teng, Mingxing; Gray, Nathanael S.

Cell Chem Biol ; 30(8): 864-878, 2023 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-37494935

11.

Unlocking DCAFs To Catalyze Degrader Development: An Arena for Innovative Approaches.

Miao, Qi; Kadam, Vilas D; Mukherjee, Ayan; Tan, Zhi; Teng, Mingxing.

J Med Chem ; 66(19): 13369-13383, 2023 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-37738232

12.

Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections.

Ye, Qiuji; Belabed, Hassane; Wang, Yong; Yu, Zhifeng; Palaniappan, Murugesan; Li, Jian-Yuan; Kalovidouris, Stacey A; MacKenzie, Kevin R; Teng, Mingxing; Young, Damian W; Fujihara, Yoshitaka; Matzuk, Martin M.

Andrology ; 11(5): 808-815, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-36209044

13.

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues.

Hassan, Muhammad Murtaza; Li, Yen-Der; Ma, Michelle W; Teng, Mingxing; Byun, Woong Sub; Puvar, Kedar; Lumpkin, Ryan; Sandoval, Brittany; Rutter, Justine C; Jin, Cyrus Y; Wang, Michelle Y; Xu, Shawn; Schmoker, Anna M; Cheong, Hakyung; Groendyke, Brian J; Qi, Jun; Fischer, Eric S; Ebert, Benjamin L; Gray, Nathanael S.

bioRxiv ; 2023 Oct 10.

Artigo em Inglês | MEDLINE | ID: mdl-37873358

14.

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.

Li, Yen-Der; Ma, Michelle W; Hassan, Muhammad Murtaza; Hunkeler, Moritz; Teng, Mingxing; Puvar, Kedar; Lumpkin, Ryan; Sandoval, Brittany; Jin, Cyrus Y; Ficarro, Scott B; Wang, Michelle Y; Xu, Shawn; Groendyke, Brian J; Sigua, Logan H; Tavares, Isidoro; Zou, Charles; Tsai, Jonathan M; Park, Paul M C; Yoon, Hojong; Majewski, Felix C; Marto, Jarrod A; Qi, Jun; Nowak, Radoslaw P; Donovan, Katherine A; Slabicki, Mikolaj; Gray, Nathanael S; Fischer, Eric S; Ebert, Benjamin L.

bioRxiv ; 2023 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-36824856

15.

The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush.

Teng, Mingxing; Young, Damian W; Tan, Zhi.

J Med Chem ; 65(21): 14289-14304, 2022 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-36265019

16.

Targeting transcription cycles in cancer.

Vervoort, Stephin J; Devlin, Jennifer R; Kwiatkowski, Nicholas; Teng, Mingxing; Gray, Nathanael S; Johnstone, Ricky W.

Nat Rev Cancer ; 22(1): 5-24, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34675395

17.

The Dawn of Allosteric BCR-ABL1 Drugs: From a Phenotypic Screening Hit to an Approved Drug.

Teng, Mingxing; Luskin, Marlise R; Cowan-Jacob, Sandra W; Ding, Qiang; Fabbro, Doriano; Gray, Nathanael S.

J Med Chem ; 65(11): 7581-7594, 2022 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-35609336

18.

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216.

Teng, Mingxing; Lu, Wenchao; Donovan, Katherine A; Sun, Jialin; Krupnick, Noah M; Nowak, Radoslaw P; Li, Yen-Der; Sperling, Adam S; Zhang, Tinghu; Ebert, Benjamin L; Fischer, Eric S; Gray, Nathanael S.

J Med Chem ; 65(1): 747-756, 2022 01 13.

Artigo em Inglês | MEDLINE | ID: mdl-34965125

19.

Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.

Teng, Mingxing; Jiang, Jie; Ficarro, Scott B; Seo, Hyuk-Soo; Bae, Jae Hyun; Donovan, Katherine A; Fischer, Eric S; Zhang, Tinghu; Dhe-Paganon, Sirano; Marto, Jarrod A; Gray, Nathanael S.

ACS Med Chem Lett ; 12(8): 1302-1307, 2021 Aug 12.

Artigo em Inglês | MEDLINE | ID: mdl-34413960

20.

Targeting oncoproteins with a positive selection assay for protein degraders.

Koduri, Vidyasagar; Duplaquet, Leslie; Lampson, Benjamin L; Wang, Adam C; Sabet, Amin H; Ishoey, Mette; Paulk, Joshiawa; Teng, Mingxing; Harris, Isaac S; Endress, Jennifer E; Liu, Xiaoxi; Dasilva, Ethan; Paulo, Joao A; Briggs, Kimberly J; Doench, John G; Ott, Christopher J; Zhang, Tinghu; Donovan, Katherine A; Fischer, Eric S; Gygi, Steven P; Gray, Nathanael S; Bradner, James; Medin, Jeffrey A; Buhrlage, Sara J; Oser, Matthew G; Kaelin, William G.

Sci Adv ; 7(6)2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33547076

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