Pesquisa | BVS Violência e Saúde

1.

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.

Landau, Dan A; Carter, Scott L; Stojanov, Petar; McKenna, Aaron; Stevenson, Kristen; Lawrence, Michael S; Sougnez, Carrie; Stewart, Chip; Sivachenko, Andrey; Wang, Lili; Wan, Youzhong; Zhang, Wandi; Shukla, Sachet A; Vartanov, Alexander; Fernandes, Stacey M; Saksena, Gordon; Cibulskis, Kristian; Tesar, Bethany; Gabriel, Stacey; Hacohen, Nir; Meyerson, Matthew; Lander, Eric S; Neuberg, Donna; Brown, Jennifer R; Getz, Gad; Wu, Catherine J.

Cell ; 152(4): 714-26, 2013 Feb 14.

Artigo em Inglês | MEDLINE | ID: mdl-23415222

2.

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Kwiatkowski, Nicholas; Zhang, Tinghu; Rahl, Peter B; Abraham, Brian J; Reddy, Jessica; Ficarro, Scott B; Dastur, Anahita; Amzallag, Arnaud; Ramaswamy, Sridhar; Tesar, Bethany; Jenkins, Catherine E; Hannett, Nancy M; McMillin, Douglas; Sanda, Takaomi; Sim, Taebo; Kim, Nam Doo; Look, Thomas; Mitsiades, Constantine S; Weng, Andrew P; Brown, Jennifer R; Benes, Cyril H; Marto, Jarrod A; Young, Richard A; Gray, Nathanael S.

Nature ; 511(7511): 616-20, 2014 Jul 31.

Artigo em Inglês | MEDLINE | ID: mdl-25043025

3.

MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL.

Improgo, Ma Reina; Tesar, Bethany; Klitgaard, Josephine L; Magori-Cohen, Reuma; Yu, Lijian; Kasar, Siddha; Chaudhary, Divya; Miao, Wenyan; Fernandes, Stacey M; Hoang, Kevin; Westlin, William F; Kim, Haesook T; Brown, Jennifer R.

Br J Haematol ; 184(6): 925-936, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30537114

4.

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.

Wang, Lili; Lawrence, Michael S; Wan, Youzhong; Stojanov, Petar; Sougnez, Carrie; Stevenson, Kristen; Werner, Lillian; Sivachenko, Andrey; DeLuca, David S; Zhang, Li; Zhang, Wandi; Vartanov, Alexander R; Fernandes, Stacey M; Goldstein, Natalie R; Folco, Eric G; Cibulskis, Kristian; Tesar, Bethany; Sievers, Quinlan L; Shefler, Erica; Gabriel, Stacey; Hacohen, Nir; Reed, Robin; Meyerson, Matthew; Golub, Todd R; Lander, Eric S; Neuberg, Donna; Brown, Jennifer R; Getz, Gad; Wu, Catherine J.

N Engl J Med ; 365(26): 2497-506, 2011 Dec 29.

Artigo em Inglês | MEDLINE | ID: mdl-22150006

5.

A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma.

Brown, Jennifer R; Messmer, Bradley; Werner, Lillian; Davids, Matthew S; Mikler, Evgeny; Supko, Jeffrey G; Fisher, David C; LaCasce, Ann S; Armand, Philippe; Jacobsen, Eric; Dalton, Virginia; Tesar, Bethany; Fernandes, Stacey M; McDonough, Sean; Ritz, Jerome; Rassenti, Laura; Kipps, Thomas J; Neuberg, Donna; Freedman, Arnold S.

Haematologica ; 98(6): 964-70, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23645694

6.

Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation.

Shen, Hua; Tesar, Bethany M; Walker, Wendy E; Goldstein, Daniel R.

J Immunol ; 181(3): 1849-58, 2008 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-18641322

7.

Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation.

Stout-Delgado, Heather W; Yang, Xin; Walker, Wendy E; Tesar, Bethany M; Goldstein, Daniel R.

J Immunol ; 181(10): 6747-56, 2008 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-18981092

8.

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection.

Goldstein, Daniel R; Tesar, Bethany M; Akira, Shizuo; Lakkis, Fadi G.

J Clin Invest ; 111(10): 1571-8, 2003 May.

Artigo em Inglês | MEDLINE | ID: mdl-12750407

9.

Toll-like receptors and their role in transplantation.

Tesar, Bethany M; Goldstein, Daniel R.

Front Biosci ; 12: 4221-38, 2007 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-17485369

10.

Acute allograft rejection occurs independently of inducible heat shock protein-70.

Tesar, Bethany M; Goldstein, Daniel R.

Transplantation ; 83(11): 1513-7, 2007 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-17565327

11.

Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging.

Tesar, Bethany M; Walker, Wendy E; Unternaehrer, Julia; Joshi, Nikhil S; Chandele, Anmol; Haynes, Laura; Kaech, Susan; Goldstein, Daniel R.

Aging Cell ; 5(6): 473-86, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17129212

12.

Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation.

Yu, Lijian; Kim, Haesook T; Kasar, Siddha; Benien, Parul; Du, Wei; Hoang, Kevin; Aw, Andrew; Tesar, Bethany; Improgo, Reina; Fernandes, Stacey; Radhakrishnan, Saranya; Klitgaard, Josephine; Lee, Charles; Getz, Gad; Setlur, Sunita R; Brown, Jennifer R.

Clin Cancer Res ; 23(3): 735-745, 2017 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-27503198

13.

Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-Î´/Î³ Inhibitors.

Ferguson, Fleur M; Ni, Jing; Zhang, Tinghu; Tesar, Bethany; Sim, Taebo; Kim, Nam Doo; Deng, Xianming; Brown, Jennifer R; Zhao, Jean J; Gray, Nathanael S.

ACS Med Chem Lett ; 7(10): 908-912, 2016 Oct 13.

Artigo em Inglês | MEDLINE | ID: mdl-27774127

14.

Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia.

Brown, Jennifer R; Tesar, Bethany; Yu, Lijian; Werner, Lillian; Takebe, Naoko; Mikler, Evgeny; Reynolds, Hazel M; Thompson, Christina; Fisher, David C; Neuberg, Donna; Freedman, A S.

Leuk Lymphoma ; 56(12): 3336-42, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25971907

15.

Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia.

Brown, Jennifer R; Hanna, Megan; Tesar, Bethany; Werner, Lillian; Pochet, Nathalie; Asara, John M; Wang, Yaoyu E; Dal Cin, Paola; Fernandes, Stacey M; Thompson, Christina; Macconaill, Laura; Wu, Catherine J; Van de Peer, Yves; Correll, Mick; Regev, Aviv; Neuberg, Donna; Freedman, Arnold S.

Clin Cancer Res ; 18(14): 3791-802, 2012 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-22623730

16.

Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation.

Shen, Hua; Tesar, Bethany M; Du, Wei; Goldstein, Daniel R.

PLoS One ; 4(1): e4097, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19119314

17.

Absence of innate MyD88 signaling promotes inducible allograft acceptance.

Walker, Wendy E; Nasr, Isam W; Camirand, Geoffrey; Tesar, Bethany M; Booth, Carmen J; Goldstein, Daniel R.

J Immunol ; 177(8): 5307-16, 2006 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-17015716

18.

TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein.

Tesar, Bethany M; Zhang, Jiasheng; Li, Qi; Goldstein, Daniel R.

Am J Transplant ; 4(9): 1429-39, 2004 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-15307830

19.

Direct antigen presentation by a xenograft induces immunity independently of secondary lymphoid organs.

Tesar, Bethany M; Chalasani, Geetha; Smith-Diggs, Lonnette; Baddoura, Fady K; Lakkis, Fadi G; Goldstein, Daniel R.

J Immunol ; 173(7): 4377-86, 2004 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-15383567

20.

Toll-like receptors and allograft rejection.

Goldstein, Daniel R; Tesar, Bethany M.

Am J Respir Crit Care Med ; 169(8): 971; author reply 971-2, 2004 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-15072988

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