Detalhe da pesquisa
1.
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
J Biol Chem
; 295(52): 17935-17949, 2020 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32900849
2.
Compounds with capacity to quench the tyrosyl radical in Pseudomonas aeruginosa ribonucleotide reductase.
J Biol Inorg Chem
; 24(6): 841-848, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31218442
3.
VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients.
Proc Natl Acad Sci U S A
; 112(22): E2900-9, 2015 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25991856
4.
Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
J Biol Chem
; 291(35): 18410-8, 2016 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27365393
5.
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Biochim Biophys Acta
; 1844(2): 439-46, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24333438
6.
Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell format.
Proc Natl Acad Sci U S A
; 109(25): 9798-803, 2012 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22665797
7.
Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design.
Chem Biol
; 15(9): 920-9, 2008 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18804029
8.
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.
PLoS One
; 13(4): e0195956, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29684045
9.
Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase.
Proteins
; 67(4): 1113-8, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17357161
10.
Structure and catalytic mechanisms of leukotriene A4 hydrolase.
Prostaglandins Other Lipid Mediat
; 83(3): 198-202, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17481555
11.
A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.
Mol Oncol
; 10(9): 1375-1386, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27511871
12.
Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa.
PLoS One
; 10(7): e0134293, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26225432
13.
The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site.
PLoS One
; 10(7): e0128199, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26147435
14.
Leukotriene A4 hydrolase.
Prostaglandins Other Lipid Mediat
; 68-69: 495-510, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12432939
15.
Improved inhibitor screening experiments by comparative analysis of simulated enzyme progress curves.
PLoS One
; 7(10): e46764, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23071631
16.
Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors.
FEBS Lett
; 584(15): 3446-51, 2010 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20609366
17.
Leukotriene A4 hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from Saccharomyces cerevisiae.
J Biol Chem
; 280(39): 33477-86, 2005 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-16024909
18.
Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.
J Biol Chem
; 277(2): 1398-404, 2002 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11675384
19.
Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.
J Biol Chem
; 279(26): 27376-82, 2004 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15078870
20.
Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.
Proc Natl Acad Sci U S A
; 99(7): 4215-20, 2002 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-11917124