Pesquisa | BVS Violência e Saúde

1.

Orphan quality control shapes network dynamics and gene expression.

Mark, Kevin G; Kolla, SriDurgaDevi; Aguirre, Jacob D; Garshott, Danielle M; Schmitt, Stefan; Haakonsen, Diane L; Xu, Christina; Kater, Lukas; Kempf, Georg; Martínez-González, Brenda; Akopian, David; See, Stephanie K; Thomä, Nicolas H; Rapé, Michael.

Cell ; 186(16): 3460-3475.e23, 2023 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-37478862

2.

Reading the chromatinized genome.

Michael, Alicia K; Thomä, Nicolas H.

Cell ; 184(14): 3599-3611, 2021 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-34146479

3.

Orphan quality control shapes network dynamics and gene expression.

Mark, Kevin G; Kolla, SriDurgaDevi; Aguirre, Jacob D; Garshott, Danielle M; Schmitt, Stefan; Haakonsen, Diane L; Xu, Christina; Kater, Lukas; Kempf, Georg; Martínez-González, Brenda; Akopian, David; See, Stephanie K; Thomä, Nicolas H; Rapé, Michael.

Cell ; 186(19): 4252-4253, 2023 Sep 14.

Artigo em Inglês | MEDLINE | ID: mdl-37714136

4.

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

Tsai, Jonathan M; Aguirre, Jacob D; Li, Yen-Der; Brown, Jared; Focht, Vivian; Kater, Lukas; Kempf, Georg; Sandoval, Brittany; Schmitt, Stefan; Rutter, Justine C; Galli, Pius; Sandate, Colby R; Cutler, Jevon A; Zou, Charles; Donovan, Katherine A; Lumpkin, Ryan J; Cavadini, Simone; Park, Paul M C; Sievers, Quinlan; Hatton, Charlie; Ener, Elizabeth; Regalado, Brandon D; Sperling, Micah T; Slabicki, Mikolaj; Kim, Jeonghyeon; Zon, Rebecca; Zhang, Zinan; Miller, Peter G; Belizaire, Roger; Sperling, Adam S; Fischer, Eric S; Irizarry, Rafael; Armstrong, Scott A; Thomä, Nicolas H; Ebert, Benjamin L.

Mol Cell ; 83(15): 2753-2767.e10, 2023 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-37478846

5.

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1.

Setiaputra, Dheva; Escribano-Díaz, Cristina; Reinert, Julia K; Sadana, Pooja; Zong, Dali; Callen, Elsa; Sifri, Chérine; Seebacher, Jan; Nussenzweig, André; Thomä, Nicolas H; Durocher, Daniel.

Mol Cell ; 82(7): 1359-1371.e9, 2022 04 07.

Artigo em Inglês | MEDLINE | ID: mdl-35216668

6.

Cooperation between bHLH transcription factors and histones for DNA access.

Michael, Alicia K; Stoos, Lisa; Crosby, Priya; Eggers, Nikolas; Nie, Xinyu Y; Makasheva, Kristina; Minnich, Martina; Healy, Kelly L; Weiss, Joscha; Kempf, Georg; Cavadini, Simone; Kater, Lukas; Seebacher, Jan; Vecchia, Luca; Chakraborty, Deyasini; Isbel, Luke; Grand, Ralph S; Andersch, Florian; Fribourgh, Jennifer L; Schübeler, Dirk; Zuber, Johannes; Liu, Andrew C; Becker, Peter B; Fierz, Beat; Partch, Carrie L; Menet, Jerome S; Thomä, Nicolas H.

Nature ; 619(7969): 385-393, 2023 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-37407816

7.

Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions.

Shi, Tianlai; Bunker, Richard D; Mattarocci, Stefano; Ribeyre, Cyril; Faty, Mahamadou; Gut, Heinz; Scrima, Andrea; Rass, Ulrich; Rubin, Seth M; Shore, David; Thomä, Nicolas H.

Cell ; 153(6): 1340-53, 2013 Jun 06.

Artigo em Inglês | MEDLINE | ID: mdl-23746845

8.

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.

Reichermeier, Kurt M; Straube, Ronny; Reitsma, Justin M; Sweredoski, Michael J; Rose, Christopher M; Moradian, Annie; den Besten, Willem; Hinkle, Trent; Verschueren, Erik; Petzold, Georg; Thomä, Nicolas H; Wertz, Ingrid E; Deshaies, Raymond J; Kirkpatrick, Donald S.

Mol Cell ; 77(5): 1092-1106.e9, 2020 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-31973889

9.

From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation.

Oleinikovas, Vladas; Gainza, Pablo; Ryckmans, Thomas; Fasching, Bernhard; Thomä, Nicolas H.

Annu Rev Pharmacol Toxicol ; 64: 291-312, 2024 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-37585660

10.

Recognition of the CCT5 di-Glu degron by CRL4^DCAF12 is dependent on TRiC assembly.

Pla-Prats, Carlos; Cavadini, Simone; Kempf, Georg; Thomä, Nicolas H.

EMBO J ; 42(4): e112253, 2023 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-36715408

11.

BANP opens chromatin and activates CpG-island-regulated genes.

Grand, Ralph S; Burger, Lukas; Gräwe, Cathrin; Michael, Alicia K; Isbel, Luke; Hess, Daniel; Hoerner, Leslie; Iesmantavicius, Vytautas; Durdu, Sevi; Pregnolato, Marco; Krebs, Arnaud R; Smallwood, Sébastien A; Thomä, Nicolas; Vermeulen, Michiel; Schübeler, Dirk.

Nature ; 596(7870): 133-137, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34234345

12.

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.

Rabl, Julius; Bunker, Richard D; Schenk, Andreas D; Cavadini, Simone; Gill, Mark E; Abdulrahman, Wassim; Andrés-Pons, Amparo; Luijsterburg, Martijn S; Ibrahim, Adel F M; Branigan, Emma; Aguirre, Jacob D; Marceau, Aimee H; Guérillon, Claire; Bouwmeester, Tewis; Hassiepen, Ulrich; Peters, Antoine H F M; Renatus, Martin; Gelman, Laurent; Rubin, Seth M; Mailand, Niels; van Attikum, Haico; Hay, Ronald T; Thomä, Nicolas H.

Mol Cell ; 75(3): 483-497.e9, 2019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31253574

13.

Design principles for cyclin K molecular glue degraders.

Kozicka, Zuzanna; Suchyta, Dakota J; Focht, Vivian; Kempf, Georg; Petzold, Georg; Jentzsch, Marius; Zou, Charles; Di Genua, Cristina; Donovan, Katherine A; Coomar, Seemon; Cigler, Marko; Mayor-Ruiz, Cristina; Schmid-Burgk, Jonathan L; Häussinger, Daniel; Winter, Georg E; Fischer, Eric S; Slabicki, Mikolaj; Gillingham, Dennis; Ebert, Benjamin L; Thomä, Nicolas H.

Nat Chem Biol ; 20(1): 93-102, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37679459

14.

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

Fischer, Eric S; Scrima, Andrea; Böhm, Kerstin; Matsumoto, Syota; Lingaraju, Gondichatnahalli M; Faty, Mahamadou; Yasuda, Takeshi; Cavadini, Simone; Wakasugi, Mitsuo; Hanaoka, Fumio; Iwai, Shigenori; Gut, Heinz; Sugasawa, Kaoru; Thomä, Nicolas H.

Cell ; 147(5): 1024-39, 2011 Nov 23.

Artigo em Inglês | MEDLINE | ID: mdl-22118460

15.

Structural mechanism of cGAS inhibition by the nucleosome.

Pathare, Ganesh R; Decout, Alexiane; Glück, Selene; Cavadini, Simone; Makasheva, Kristina; Hovius, Ruud; Kempf, Georg; Weiss, Joscha; Kozicka, Zuzanna; Guey, Baptiste; Melenec, Pauline; Fierz, Beat; Thomä, Nicolas H; Ablasser, Andrea.

Nature ; 587(7835): 668-672, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32911482

16.

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.

Slabicki, Mikolaj; Kozicka, Zuzanna; Petzold, Georg; Li, Yen-Der; Manojkumar, Manisha; Bunker, Richard D; Donovan, Katherine A; Sievers, Quinlan L; Koeppel, Jonas; Suchyta, Dakota; Sperling, Adam S; Fink, Emma C; Gasser, Jessica A; Wang, Li R; Corsello, Steven M; Sellar, Rob S; Jan, Max; Gillingham, Dennis; Scholl, Claudia; Fröhling, Stefan; Golub, Todd R; Fischer, Eric S; Thomä, Nicolas H; Ebert, Benjamin L.

Nature ; 585(7824): 293-297, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32494016

17.

The CRL4^DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.

Mohamed, Weaam I; Schenk, Andreas D; Kempf, Georg; Cavadini, Simone; Basters, Anja; Potenza, Alessandro; Abdul Rahman, Wassim; Rabl, Julius; Reichermeier, Kurt; Thomä, Nicolas H.

EMBO J ; 40(22): e108008, 2021 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-34595758

18.

Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting.

Matsumoto, Syota; Cavadini, Simone; Bunker, Richard D; Grand, Ralph S; Potenza, Alessandro; Rabl, Julius; Yamamoto, Junpei; Schenk, Andreas D; Schübeler, Dirk; Iwai, Shigenori; Sugasawa, Kaoru; Kurumizaka, Hitoshi; Thomä, Nicolas H.

Nature ; 571(7764): E6, 2019 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-31239520

19.

DNA damage detection in nucleosomes involves DNA register shifting.

Matsumoto, Syota; Cavadini, Simone; Bunker, Richard D; Grand, Ralph S; Potenza, Alessandro; Rabl, Julius; Yamamoto, Junpei; Schenk, Andreas D; Schübeler, Dirk; Iwai, Shigenori; Sugasawa, Kaoru; Kurumizaka, Hitoshi; Thomä, Nicolas H.

Nature ; 571(7763): 79-84, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31142837

20.

FANallyA Structure Emerges of the Fanconi Anemia Core Complex.

Aguirre, Jacob D; Thomä, Nicolas H.

Trends Biochem Sci ; 45(4): 275-276, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-31987666

BVS Violência e Saúde

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar:

Orphan quality control shapes network dynamics and gene expression.

Reading the chromatinized genome.

Orphan quality control shapes network dynamics and gene expression.

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1.

Cooperation between bHLH transcription factors and histones for DNA access.

Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions.

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.

From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation.

Recognition of the CCT5 di-Glu degron by CRL4^DCAF12 is dependent on TRiC assembly.

BANP opens chromatin and activates CpG-island-regulated genes.

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.

Design principles for cyclin K molecular glue degraders.

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

Structural mechanism of cGAS inhibition by the nucleosome.

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.

The CRL4^DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.

Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting.

DNA damage detection in nucleosomes involves DNA register shifting.

FANallyA Structure Emerges of the Fanconi Anemia Core Complex.