Detalhe da pesquisa
1.
Phospholipid headgroups govern area per lipid and emergent elastic properties of bilayers.
Biophys J
; 121(21): 4205-4220, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36088534
2.
Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.
Inflamm Res
; 68(4): 261-274, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30739130
3.
Histamine H4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice.
Pharmacol Res
; 128: 18-28, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29309903
4.
A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma.
Ann Allergy Asthma Immunol
; 121(5): 568-574, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30102965
5.
Efficacy and Safety of Toreforant, a Selective Histamine H4 Receptor Antagonist, for the Treatment of Moderate-to-Severe Plaque Psoriasis: Results from a Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled Trial.
J Drugs Dermatol
; 17(8): 873-879, 2018 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30124726
6.
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
Pharmacol Rev
; 67(3): 601-55, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26084539
7.
Clinical Development of Histamine H4 Receptor Antagonists.
Handb Exp Pharmacol
; 241: 301-320, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28233185
8.
Histamine synthesis is required for granule maturation in murine mast cells.
Eur J Immunol
; 44(1): 204-14, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24002822
9.
Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H4 receptor modulators.
Bioorg Med Chem Lett
; 25(4): 956-9, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25595684
10.
Antihistamines and itch.
Handb Exp Pharmacol
; 226: 257-90, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25861785
11.
Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979.
J Pharmacol Exp Ther
; 349(2): 176-84, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24549371
12.
Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment.
J Pharmacol Exp Ther
; 351(2): 308-16, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25185215
13.
The histamine H4 receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.
J Pharmacol Exp Ther
; 350(1): 181-7, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24817035
14.
Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.
J Pharmacol Exp Ther
; 349(3): 508-17, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24696042
15.
The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.
Ann Rheum Dis
; 73(3): 600-8, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24126456
16.
The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands.
Bioorg Med Chem Lett
; 24(23): 5489-92, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25455490
17.
Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system.
J Immunol
; 188(2): 541-7, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22147765
18.
Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo.
Inflamm Res
; 62(6): 599-607, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23532396
19.
Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation.
Eur J Immunol
; 41(6): 1764-73, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21469095
20.
Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels.
J Exp Med
; 202(3): 387-93, 2005 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061728