Detalhe da pesquisa
1.
Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity.
Proc Natl Acad Sci U S A
; 120(13): e2214171120, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36947514
2.
Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine.
J Neurosci
; 44(19)2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38569927
3.
Potent and selective NOP receptor activation reduces cocaine self-administration in rats by lowering hedonic set point.
Addict Biol
; 25(6): e12844, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31709687
4.
NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL/6J Mice.
Alcohol Clin Exp Res
; 43(10): 2167-2178, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31386211
5.
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
Br J Anaesth
; 122(6): e146-e156, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30916003
6.
NOP-Related Mechanisms in Pain and Analgesia.
Handb Exp Pharmacol
; 254: 165-186, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31119465
7.
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.
Pharmacol Rev
; 68(2): 419-57, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26956246
8.
Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization.
J Neurosci
; 35(33): 11682-93, 2015 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26290245
9.
Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of ß2-adrenoceptor.
J Biol Chem
; 289(28): 19351-63, 2014 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24831005
10.
Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the ß2-adrenergic receptor.
Bioorg Med Chem
; 22(1): 234-46, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24326276
11.
Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain.
Pain
; 165(3): 685-697, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37820238
12.
Synthesis of α3ß4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline That Reduce Reinstatement of Cocaine-Seeking Behavior.
J Med Chem
; 67(1): 529-542, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151460
13.
Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors.
J Pharmacol Exp Ther
; 346(3): 545-54, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23853171
14.
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.
FASEB J
; 26(2): 947-54, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22038051
15.
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.
Bioorg Med Chem Lett
; 23(11): 3308-13, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23623415
16.
Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies.
J Pept Sci
; 19(1): 16-24, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23193084
17.
Preclinical effects of cannabidiol in an experimental model of migraine.
Pain
; 164(11): 2540-2552, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310430
18.
A novel G protein-biased agonist at the µ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase.
Br J Pharmacol
; 180(7): 943-957, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33245558
19.
Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders.
bioRxiv
; 2023 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37461723
20.
Thermodynamics and docking of agonists to the ß(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand.
Mol Pharmacol
; 81(6): 846-54, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22434858