RESUMO
Chloroform (CHCl3) and bromodichloromethane (CHBrCl2) are the two most common haloorganic contaminants of chlorinated drinking water. A significantly increased incidence of hepatic neoplastic nodules was found in female rats when either of these compounds was administered in drinking water to Wistar rats throughout their life-span. Hepatic adenofibrosis was also produced by chronic ingestion of these two halomethanes.
Assuntos
Clorofórmio/toxicidade , Hidrocarbonetos Halogenados/toxicidade , Neoplasias Experimentais/patologia , Animais , Peso Corporal/efeitos dos fármacos , Carcinógenos , Linhagem Celular , Feminino , Masculino , Ratos , Ratos Endogâmicos , TrialometanosAssuntos
Anormalidades Induzidas por Medicamentos , Monóxido de Carbono/toxicidade , Embrião de Galinha/efeitos dos fármacos , Animais , Proteínas Sanguíneas/análise , Monóxido de Carbono/sangue , Exposição Ambiental , Hematócrito , Hemoglobinas , Concentração de Íons de Hidrogênio , L-Lactato Desidrogenase/sangue , Oxigênio/sangue , Tonometria OcularRESUMO
Chloroform (CHCl3) and bromodichloromethane (CHBrCl2) are the two most common haloorganic contaminants of chlorinated drinking water. A significantly increased incidence of hepatic neoplastic nodules was found in female rats when each of these compounds was administered in drinking water to Wistar rats throughout their life span. Hepatic adenofibrosis was also produced by chronic ingestion of these two halomethanes.
Assuntos
Clorofórmio/toxicidade , Hidrocarbonetos Halogenados/toxicidade , Neoplasias Experimentais/induzido quimicamente , Adenofibroma/induzido quimicamente , Envelhecimento , Animais , Peso Corporal/efeitos dos fármacos , Feminino , Masculino , Ratos , Ratos Endogâmicos , TrialometanosRESUMO
Aroclor 1254 was fed to female and male rats daily for 9 weeks at a dose of 6.4 mg/kg in their drinking water. Control animals received plain tap water plus the emulsified (0.15% Tween 80). Elevated mixed function oxidase (MFO) activity appeared to be due to 2,4,5,2',4',5'- and 2,4,5,2'3'4'-hexachlorobiphenyls, since only these compounds were present to any degree in the tissues of the animals when MFO activity persisted after termination of exposure. The placenta apparently is an effective barrier to PCB transfer.