Detalhe da pesquisa
1.
Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Biochim Biophys Acta
; 1861(9 Pt A): 1132-1141, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27344248
2.
Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.
J Biol Chem
; 289(43): 29881-91, 2014 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25157099
3.
Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats.
J Lipid Res
; 54(5): 1369-84, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23449193
4.
ACAT-selective and nonselective DGAT1 inhibition: adrenocortical effects--a cross-species comparison.
Toxicol Pathol
; 41(7): 941-50, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23427273
5.
Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.
J Lipid Res
; 53(11): 2364-79, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22911105
6.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
Bioorg Med Chem Lett
; 22(12): 3873-8, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22608962
7.
DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle.
J Lipid Res
; 52(4): 732-44, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21205704
8.
Diacylglycerol acyltransferases: Potential roles as pharmacological targets.
Pharmacol Ther
; 118(3): 295-302, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18508126
9.
Glucagon challenge in the rat: a robust method for the in vivo assessment of Glycogen phosphorlyase inhibitor efficacy.
J Pharmacol Toxicol Methods
; 55(1): 71-7, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-16713718
10.
Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats.
Diabetes
; 51(8): 2441-9, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12145156
11.
Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice.
Endocrinology
; 144(5): 1894-906, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12697697
12.
Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance.
Endocrinology
; 144(3): 760-6, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12586751
13.
Rat anterior pituitary folliculostellate cells are targets of interleukin-1beta and a major source of intrapituitary follistatin.
Endocrinology
; 144(2): 732-40, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12538636
14.
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.
J Med Chem
; 45(16): 3509-23, 2002 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12139462
15.
Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).
J Med Chem
; 57(11): 4466-86, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24294985
16.
Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice.
J Med Chem
; 57(3): 970-86, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24422550
17.
11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11ß-HSD1 is knocked out in livers of male mice.
Endocrinology
; 154(10): 3599-609, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23832962
18.
11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors still improve metabolic phenotype in male 11ß-HSD1 knockout mice suggesting off-target mechanisms.
Endocrinology
; 154(12): 4580-93, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24169553
19.
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
J Med Chem
; 55(23): 10610-29, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23116186
20.
DGAT1 inhibitors as anti-obesity and anti-diabetic agents.
Curr Opin Drug Discov Devel
; 13(4): 489-96, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20597032