The Predictive Role of NLR, d-NLR, MLR, and SIRI in COVID-19 Mortality.

(1) Background: Since its discovery, COVID-19 has caused more than 256 million cases, with a cumulative death toll of more than 5.1 million, worldwide. Early identification of patients at high risk of mortality is of great importance in saving the lives of COVID-19 patients. The study aims to assess the utility of various inflammatory markers in predicting mortality among hospitalized patients with COVID-19. (2) Methods: A retrospective observational study was conducted among 108 patients with laboratory-confirmed COVID-19 hospitalized between 1 May 2021 and 31 October 2021 at Municipal Emergency Clinical Hospital of Timisoara, Romania. Blood cell counts at admission were used to obtain NLR, dNLR, MLR, PLR, SII, and SIRI. The association of inflammatory index and mortality was assessed via Kaplan-Maier curves univariate Cox regression and binominal logistic regression. (3) Results: The median age was 63.31 ± 14.83, the rate of in-hospital death being 15.7%. The optimal cutoff for NLR, dNLR, MLR, and SIRI was 9.1, 9.6, 0.69, and 2.2. AUC for PLR and SII had no statistically significant discriminatory value. The binary logistic regression identified elevated NLR (aOR = 4.14), dNLR (aOR = 14.09), and MLR (aOR = 3.29), as independent factors for poor clinical outcome of COVID-19. (4) Conclusions: NLR, dNLR, MLR have significant predictive value in COVID-19 mortality.

Impact of Stress and Financials on Romanian Infertile Women Accessing Assisted Reproductive Treatment.

Around 20% of couples worldwide are affected by infertility issues, with numbers in the European Union reaching as high as 25%, while access to reproductive care varies significantly by geopolitical and country-specific variables. The purpose of this research is to shed light on the unique social, psychological, and financial difficulties faced by Romanian couples seeking access to assisted reproductive therapy (ART). A cross-sectional study was conducted between 2017 and 2019 to involve women who accessed ART at fertility clinics in Romania by completing two infertility surveys. We analyzed the data in terms of all facets of infertility and ART, including the effect of personal background and stress levels on succeeding to conceive, the impact of treatment costs, and household income. A total of 829 participants completed the survey. We observed that high stress exposure leads to a substantially higher duration to conceive using ART, although the proportions of successful pregnancies did not differ between low-stress and high-stress groups. A significantly higher number of couples achieved pregnancy when their monthly household income was higher than EUR 1000 and if the ART method was more expensive. Additionally, we observed that advanced age, high stress levels, and the high cost of ART had a negative association with achieving pregnancy using ART. The findings indicated that Romanian couples experiencing infertility must contend with significant expenses for specialist infertility treatments, as well as treatment-related stress, both of which have a detrimental effect on their odds of attaining conception.

Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications.

We designed and implemented a prospective study to analyze the maternal and neonatal outcomes associated with COVID-19 and determine the likelihood of viral transmission to the fetus and newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, and breast milk. The study followed a prospective observational design, starting in July 2020 and lasting for one year. A total of 889 pregnant women were routinely tested for SARS-CoV-2 infection in an outpatient setting at our clinic, using nasal swabs for PCR testing. A total of 76 women were diagnosed with COVID-19. The positive patients who accepted study enrollment were systematically analyzed by collecting weekly nasal, urine, fecal, and serum samples, including amniotic fluid, placenta, umbilical cord, and breast milk at hospital admission and postpartum. Mothers with COVID-19 were at a significantly higher risk of developing gestational hypertension and giving birth prematurely by c-section than the general pregnant population. Moreover, their mortality rates were substantially higher. Their newborns did not have negative outcomes, except for prematurity, and an insignificant number of newborns were infected with SARS-CoV-2 (5.4%). No amniotic fluid samples were positive for SARS-CoV-2, and only 1.01% of PCR tests from breast milk were confirmed positive. Based on these results, we support the idea that SARS-CoV-2 positive pregnant women do not expose their infants to an additional risk of infection via breastfeeding, close contact, or in-utero. Consequently, we do not support maternal-newborn separation at delivery since they do not seem to be at an increased risk of SARS-CoV-2 infection.

High School Pupils' Relationships with Their Parents, Schoolmates, and Friends, and Health-Related Risk Behaviors.

PURPOSE: The aims of this study were to evaluate high school pupils' relationships with their parents, schoolmates, and friends, and the presence of health-related risk behaviors among the family members and friends on the pupils' smoking and binge drinking status. MATERIALS AND METHODS: The study was a cross-sectional population-based study that involved a questionnaire, and the sample involved 2908 pupils at high schools in Timis county, Romania. In our study, the following factors related to family members and friends and the living environment were identified. First, there were issues with the relationships with parents among some pupils, with 23.2% being neither satisfied nor unsatisfied and 4.9% being unsatisfied. Second, there were also issues regarding some pupils' satisfaction with the financial situation of their family, with 21.8% being neither satisfied nor unsatisfied and 16.4% being unsatisfied. An odds ratio (OR) is a statistic that quantifies the strength of the association between two events. RESULTS: There were 1495 (51.5%) girls and 1407 (48.5%) boys aged 14-20 years, and 79.2% came from organized families. Among the pupils, 71.1% reported that they were satisfied with their relationship with their parents, while 4.9% were unsatisfied. Additionally, 46.2% were satisfied with the financial status of their families, while 16.4% were unsatisfied. Moreover, 59.2% were satisfied with their relationship with their schoolmates and 80.2% were satisfied with their relationship with their friends, while only 1.8% were unsatisfied with their relationship with their friends. The logistic regression model of the pupils' smoking status identified two moderate predictive factors: this was defined ">1" friends who smoke (odds ratio [OR]=2.875) and smoking status of siblings (OR=2.222). The major predictive factor in the logistic regression model of occasional alcohol consumption in high quantities by pupils was male gender (OR=5.148). CONCLUSION: The predictive model of pupils' smoking status identified the following moderate predictors: high number of friends who smoke and smoking status of siblings. The major predictor in the model of occasional alcohol consumption in high quantities by pupils was male gender.

MANIFESTATIONS OF SELF-HARM IN RELATION WITH BINGE DRINKING TO STUDENTS FROM TIMIS COUNTY, ROMÂNIA.

AIM: The research investigated the feeling of sadness, suicidal thoughts and plans associated with binge drinking among students in Timis County, Romania. MATERIAL AND METHODS: We applied a transversal population study to the representative sample of 2076 students, 62.49% girls and 37.51% boys with a mean age of 21.09 years with SD 1.48. RESULTS: The boys practice binge drinking significantly more often than girls, the difference is small to medium: prevalence of 22.1% for boys and 8.7% girls, 1-2 times in the last month. CONCLUSIONS: Only girls who practice this behavior, increased frequency of engaging in binge drinking is associated with feelings of sadness, suicidal thoughts and suicide plans in a small measure, but significant.

Predictors of quantitative microbiological analysis of spatter and aerosolization during scaling.

UNLABELLED: The aim of this study is to analyze the infection risk through spatter and aerosolization during scaling and to create a prediction model of the total number of hemolytic bacteria. MATERIAL AND METHODS: Air samples were collected prior to patient's arrival and spatter and aerosol samples were collected during scaling procedure in 80 patients of 4 different dental clinics. The dentists calculated DI, CI, DMFT. Only patients with CI > = 1 were included. The bacteriological results (CFU/m3) were correlated with clinical indicators. Patients were divided into 2 groups: one that rinse with sterile water and the other with chlohexidine mouth rinse 0.1%. RESULTS AND CONCLUSIONS: Medium size effect positive correlations were found between the number of decayed teeth and the total number of bacteria and the total number of hemolytic bacteria that grew on plate attached to the dentist's mask. The mean number of bacteria and the mean number of hemolytic bacteria that grew on plate attached to the dentist's mask were significantly lower in the group that rinse with chlorhexidine 0.1%, when compared to the group that rinsed with sterile water. When controlling for the total number of bacteria and the total number of hemolytic bacteria from air sampling, the total number of hemolytic bacteria that grew on the plate attached to the dentist's mask can be predicted by CI, group membership and DMFT score.

Features of pubertal maturation in adolescents from Timis County.

AIM: Puberty, by content and finality, mean all the events of somatic and mental maturation, with the transformation of the child into an adult. It is the period in which it is acquired the reproductive capacity. MATERIAL AND METHODS: Pubertal maturation was studied on a sample of secondary school adolescents from Timis County, 800 students from schools and high schools in the urban area aged 11-14 years, with uniform distribution by sex and age. The pubertal evaluation was made with reference to Tanner stages. The result was an earlier and stronger pubertal maturation in girls compared with boys. RESULTS: Pubertal maturation in adolescents from Timis County is higher compared to the national level (step 1999), and is less elevated compared with the local level of maturation (1998). CONCLUSIONS: The study contributes to maintain actual the health condition in adolescence.

Dietary patterns in young adults from Timis County.

UNLABELLED: Dietary patterns present at the age of the young adult have great probability to remain unchanged for the rest of the life and may contribute to eating disorders later in life. The aim of this study is the analysis of the intake patterns for fruits and vegetables in students from Timis County. MATERIAL AND METHODS: We conducted a cross sectional study using a stratified cluster sample design to produce a representative sample of students for the Timis County. The students' sample totalized 2076 students from the universities in Timis County. RESULTS: A large percent of the young people participating in the study (41.9%) does not consume fresh juices. For the consumption of fresh fruits, the present results back up the international di scoveries, only 32.8% of the young people consuming fruits daily, which is a smaller percent that the medium value reported by other countries. The frequency of consumption for fruits differs according to gender, being higher for girls. For salads, the percent of young people consuming this type of foods at least once a day is 17.0%, much lower compared to 32.8% of the young people consuming fresh fruits at least once a day. CONCLUSIONS: The examination of the dietary patterns related to the intake of fruits and vegetables helped us to determine priority areas for future interventions.