Detalhe da pesquisa
1.
Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg Med Chem
; 26(3): 647-660, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29291937
2.
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors.
Bioorg Med Chem
; 24(23): 6149-6165, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27825552
3.
Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1â³ binding site.
Bioorg Med Chem
; 22(19): 5487-505, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25192810
4.
Simple and Practical Method for the Quantitative High-Sensitivity Analysis of N-Nitroso Duloxetine in Duloxetine Drug Products Utilizing LC-MS/MS.
ACS Omega
; 9(11): 13440-13446, 2024 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38524415
5.
Correction to "N-Nitrosodimethylamine Formation in Metformin Drug Products by the Reaction of Dimethylamine and Atmospheric NO2".
Org Process Res Dev
; 28(1): 325, 2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38268772
6.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7326-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23147077
7.
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
J Med Chem
; 64(6): 3059-3074, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33682410
8.
Repurposing bromocriptine for Aß metabolism in Alzheimer's disease (REBRAnD) study: randomised placebo-controlled double-blind comparative trial and open-label extension trial to investigate the safety and efficacy of bromocriptine in Alzheimer's disease with presenilin 1 (PSEN1) mutations.
BMJ Open
; 11(6): e051343, 2021 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34193504
9.
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
J Med Chem
; 60(2): 608-626, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27966948
10.
Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist.
Neuropharmacology
; 48(2): 301-10, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15695169
11.
Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.
J Med Chem
; 45(19): 4222-39, 2002 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-12213063
12.
Synthesis of a novel series of benzocycloalkene derivatives as melatonin receptor agonists.
J Med Chem
; 45(19): 4212-21, 2002 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-12213062
13.
The sleep-promoting action of ramelteon (TAK-375) in freely moving cats.
Sleep
; 27(7): 1319-25, 2004 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15586784
14.
Kinetic resolution of an indan derivative using Bacillus sp. SUI-12: synthesis of a key intermediate of the melatonin receptor agonist TAK-375.
J Biosci Bioeng
; 93(1): 44-7, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-16233163
15.
Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.
J Med Chem
; 57(21): 8886-902, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25264600
16.
Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.
J Med Chem
; 54(12): 4207-18, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568291
17.
1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT2-selective agonists.
J Med Chem
; 54(9): 3436-44, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21473625