Assuntos
Anti-Inflamatórios/farmacologia , DNA/metabolismo , Inflamação/metabolismo , RNA/metabolismo , Animais , Carragenina , Gossypium , Inflamação/etiologia , Masculino , RatosRESUMO
Bordetella pertussis vaccine, a hypoglycemic agent significantly prolonged the bleeding time and whole blood coaguistion time in rabbits and dogs when administered intraperitonially. The vaccine also affects platelet aggregation in rats 4 days after its intraperitonial administration. The effect on platelet aggregation is thought to be due to its beta adrenargic receptor blocking action which may also contribute to the hypoglycemia.
Assuntos
Tempo de Sangramento , Testes de Coagulação Sanguínea , Vacina contra Coqueluche/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Testes de Função Plaquetária , Tempo de Coagulação do Sangue Total , Animais , Cães , Feminino , Masculino , Coelhos , Ratos , Receptores Adrenérgicos beta/efeitos dos fármacosRESUMO
1 A 'GSH (reduced glutathione) stability test' which consists of incubating blood samples with acetylphenylhydrazine and other test drugs and measuring GSH level before and after incubation, was carried out. 2 Application of this test to the blood of eight normal volunteers and twelve known G-6-PD deficient persons demonstrated that acetylphenylhydrazine and primaquine produced a significant decrease in GSH levels in G-6-PD deficient red cells compared to the reduction seen in normal red cells incubated with these drugs. No such change was observed with aspirin, ibuprofen and flurbiprofen. 3 The results of this in vitro study seem to indicate that ibuprofen and flurbiprofen are relatively innocuous in G-6-PD deficient individuals.