Detalhe da pesquisa
1.
The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary.
Drug Metab Dispos
; 52(3): 198-209, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123948
2.
An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation.
Chem Res Toxicol
; 33(1): 20-37, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31625725
3.
Microphysiological Systems: A Pathologist's Perspective.
Vet Pathol
; 57(3): 358-368, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32180532
4.
Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective.
Regul Toxicol Pharmacol
; 117: 104746, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32911461
5.
MicroRNA as biomarkers of mitochondrial toxicity.
Toxicol Appl Pharmacol
; 312: 26-33, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26476301
6.
D-α-tocopheryl polyethylene glycol 1000 succinate-containing vehicles provide no detectable chemoprotection from oxidative damage.
J Appl Toxicol
; 35(7): 791-8, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25348750
7.
Determination of relative Notch1 and gamma-secretase-related gene expression in puromycin-treated microdissected rat kidneys.
Gene Expr
; 16(1): 39-47, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24397211
8.
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects.
J Pharmacol Toxicol Methods
; 123: 107468, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37553032
9.
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models.
J Pharmacol Toxicol Methods
; 120: 107251, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36792039
10.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Adv Biol (Weinh)
; : e2300131, 2023 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37814378
11.
Preclinical species gene expression database: Development and meta-analysis.
Front Genet
; 13: 1078050, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36733943
12.
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).
ALTEX
; 39(2): 297314, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064273
13.
Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications.
Lab Chip
; 20(6): 1049-1057, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32073020
14.
A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies.
Lab Chip
; 20(3): 468-476, 2020 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31989145
15.
Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry.
Lab Chip
; 20(2): 215-225, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31799979
16.
Screening Strategies and Methods for Better Off-Target Liability Prediction and Identification of Small-Molecule Pharmaceuticals.
SLAS Discov
; 24(1): 1-24, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30196745
17.
Novel Computational Approach to Predict Off-Target Interactions for Small Molecules.
Front Big Data
; 2: 25, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-33693348
18.
Potential mechanisms of target-independent uptake and toxicity of antibody-drug conjugates.
Pharmacol Ther
; 200: 110-125, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31028836
19.
Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.
J Pharmacol Toxicol Methods
; 99: 106580, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085318
20.
An In Vitro Model of Hematotoxicity: Differentiation of Bone Marrow-Derived Stem/Progenitor Cells into Hematopoietic Lineages and Evaluation of Lineage-Specific Hematotoxicity.
Curr Protoc Toxicol
; 76(1): e45, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30040226