1.
Bioorg Med Chem
; 10(10): 3245-55, 2002 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12150870
RESUMO
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.