RESUMO
The study group included 2161 patients operated on in 1968-1990. Tumors stage I were morphologically confirmed in 910 cases (T1S-3, T1-375 and T2-532). 827 patients survived 5 years (90.9%); 551 patients-10 years (60.3%). Primary multiple neoplasms (PMN) of different localization were detected in 96 (10.6%) patients with stage I tumors. Thirteen patients (13.5%) died of progression of a second tumor; 17 (17%)-of other causes. Average 5-year survival was 65%, 10 years-53%. These indices in 96 patients with PMNs were 73 and 53%, respectively. Relative risk of PMN in lung cancer was found to be in direct correlation with survival time and to depend, to a large degree, on tumor extension. When PMNs are detected early and treated radically, new primary tumors emergence does not significantly in lung cancer stage I. Preliminary results showed chemotherapy (neoadjuvant one included) to lower the risk of PMN in lung cancer stage I. The most plausible causes of enhanced survival of patients with PMNs are discussed.
Assuntos
Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/patologia , Neoplasias Primárias Múltiplas/mortalidade , Neoplasias Primárias Múltiplas/patologia , Feminino , Humanos , Neoplasias Pulmonares/terapia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Primárias Múltiplas/terapia , Análise de SobrevidaRESUMO
6,212 lung cancer patients have been examined and treated. The data on surgical and combined treatment of 2,702 patients have been analyzed. Postoperative complication incidence has dropped to 5.4% in recent years. End results have improved due to use of organ-saving, reconstructive and plastic procedures for the bronchi and trachea in conjunction with radiotherapy.
Assuntos
Neoplasias Pulmonares/radioterapia , Neoplasias Pulmonares/cirurgia , Adulto , Idoso , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Radioterapia Adjuvante , Estudos Retrospectivos , Análise de Sobrevida , Resultado do TratamentoRESUMO
Surgery for primary multiple malignant tumors of the respiratory system was carried out in 141 patients. Reconstruction, plastic operations and sparing resections were performed in 79 cases (68.5%). Five-year survival after radical surgery was 43.8%.
Assuntos
Neoplasias Primárias Múltiplas/radioterapia , Neoplasias Primárias Múltiplas/cirurgia , Neoplasias do Sistema Respiratório/radioterapia , Neoplasias do Sistema Respiratório/cirurgia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pneumonectomia/métodos , Radioterapia Adjuvante , Procedimentos de Cirurgia Plástica , Estudos Retrospectivos , Análise de Sobrevida , Resultado do TratamentoRESUMO
The data on the surgical and combined treatment of 35 cases of lung cancer associated with pleural effusion detected during surgery have been evaluated. Mean 5-year survival was 68.5%, pleural effusion--70%.
Assuntos
Neoplasias Pulmonares/cirurgia , Derrame Pleural Maligno/cirurgia , Pneumonectomia , Adulto , Idoso , Terapia Combinada , Feminino , Humanos , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/terapia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Derrame Pleural Maligno/terapia , Pneumonectomia/métodos , Estudos Retrospectivos , Resultado do TratamentoRESUMO
The paper presents concentrations of atrial sodium-uretic hormone (AH) in the plasma of hypertensive subjects during a hypertensive crisis and in stable blood pressure, in healthy subjects (12, 19 and 7 females, respectively). AH levels were the highest in hypertensives in the crisis. Mean AH concentrations in the crisis and short after the pressure normalization did not differ much. Mechanisms of these phenomena are discussed, relations between AH levels, clinical and hemodynamic characteristics of hypertensive crises are considered.