Detalhe da pesquisa
1.
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
Cell
; 179(1): 147-164.e20, 2019 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31539493
2.
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.
Cell
; 173(3): 720-734.e15, 2018 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29677515
3.
Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
Cell
; 161(4): 919-32, 2015 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25957690
4.
A mistranslation-prone transcriptome underlying polyglutamine expansion diseases.
Nat Rev Mol Cell Biol
; 22(9): 583-584, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33833432
5.
Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
Cell
; 168(5): 944, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235202
6.
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
Proc Natl Acad Sci U S A
; 121(7): e2313465121, 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38324572
7.
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
Nat Chem Biol
; 20(5): 634-645, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38632492
8.
The amyloid state and its association with protein misfolding diseases.
Nat Rev Mol Cell Biol
; 15(6): 384-96, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24854788
9.
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions.
Cell
; 144(1): 67-78, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21215370
10.
Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation.
Proc Natl Acad Sci U S A
; 120(40): e2300215120, 2023 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37774095
11.
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
Proc Natl Acad Sci U S A
; 120(21): e2216234120, 2023 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37186840
12.
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.
Proc Natl Acad Sci U S A
; 120(9): e2208792120, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802433
13.
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
EMBO J
; 40(21): e107568, 2021 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34617299
14.
Sequence-based prediction of pH-dependent protein solubility using CamSol.
Brief Bioinform
; 24(2)2023 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719110
15.
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
Mol Cell
; 65(6): 1096-1108.e6, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28306505
16.
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins.
Nucleic Acids Res
; 51(W1): W198-W206, 2023 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36987846
17.
Adsorption free energy predicts amyloid protein nucleation rates.
Proc Natl Acad Sci U S A
; 119(31): e2109718119, 2022 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35901206
18.
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Proc Natl Acad Sci U S A
; 119(31): e2205412119, 2022 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858383
19.
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
Acc Chem Res
; 56(12): 1395-1405, 2023 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37071750
20.
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity.
J Chem Inf Model
; 64(3): 590-596, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38261763