1.
Bioorg Med Chem Lett
; 18(20): 5653-6, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18799312
RESUMO
Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT(1A/1B/1D) receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.