1.
Org Biomol Chem
; 8(2): 442-50, 2010 Jan 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20066282
RESUMO
A study of the effect of substrate structure on a Claisen-aza-Cope reaction is presented including a rationalisation of the reaction outcome using DFT calculations. An asymmetric version of the reaction is also described that is of relevance to a proposed approach to the communesin family of natural products.
Assuntos
Indóis/química , Quinolinas/química , Produtos Biológicos/síntese química , Teoria Quântica , Termodinâmica
2.
Chem Commun (Camb)
; 52(71): 10747-50, 2016 Sep 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27507662
RESUMO
The synthesis of dehaloperophoramidine, a non-halogenated derivative of the marine natural product perophoramidine, and its biological activity towards HCT116, HT29 and LoVo colorectal carcinoma cells is reported. A [3,3]-Claisen rearrangement and an epoxide opening/allylsilylation reaction installed the contiguous all-carbon quaternary stereocentres with the required relative stereochemistry.