Detalhe da pesquisa
1.
mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.
Mol Cell
; 71(5): 675-688.e6, 2018 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30193095
2.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Mol Syst Biol
; 20(4): 428-457, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38467836
3.
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
Mol Cell
; 65(6): 1096-1108.e6, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28306505
4.
Polyglutamine disease proteins: Commonalities and differences in interaction profiles and pathological effects.
Proteomics
; : e2300114, 2024 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38615323
5.
The polyphenol EGCG directly targets intracellular amyloid-ß aggregates and promotes their lysosomal degradation.
J Neurochem
; 166(2): 294-317, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37165774
6.
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
EMBO J
; 37(2): 282-299, 2018 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29212816
7.
Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Mol Psychiatry
; 26(9): 5441-5463, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32514103
8.
Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.
EMBO Rep
; 21(3): e48530, 2020 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32003148
9.
DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
J Cell Sci
; 132(17)2019 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31391242
10.
Complete suppression of Htt fibrillization and disaggregation of Htt fibrils by a trimeric chaperone complex.
EMBO J
; 40(19): e109413, 2021 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34605047
11.
The pathobiology of perturbed mutant huntingtin protein-protein interactions in Huntington's disease.
J Neurochem
; 151(4): 507-519, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31418858
12.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Mol Syst Biol
; 14(7): e8071, 2018 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29997244
13.
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Hum Mol Genet
; 25(8): 1600-18, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26908611
14.
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
Genome Res
; 25(5): 701-13, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25908449
15.
Amyloid-ß(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity.
J Biol Chem
; 291(37): 19590-606, 2016 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27458018
16.
Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.
J Am Chem Soc
; 139(16): 5640-5643, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28406616
17.
Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins.
NMR Biomed
; 30(1)2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27859838
18.
Correction: Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Mol Psychiatry
; 26(9): 5464, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32709993
19.
Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.
Proc Natl Acad Sci U S A
; 111(33): 12085-90, 2014 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092318
20.
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
Hum Mol Genet
; 23(15): 4142-60, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24705354