Detalhe da pesquisa
1.
Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg Med Chem
; 100: 117618, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38309201
2.
The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Bioorg Med Chem
; 28(23): 115791, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33059303
3.
Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.
Bioorg Med Chem Lett
; 29(16): 2410-2414, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31160176
4.
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Bioorg Med Chem
; 27(8): 1456-1478, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858025
5.
Structure-guided optimization of small molecule c-Abl activators.
J Comput Aided Mol Des
; 28(2): 75-87, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24573412
6.
Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
J Med Chem
; 67(3): 2049-2065, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38284310
7.
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Bioorg Med Chem Lett
; 22(12): 4028-32, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22579486
8.
Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.
J Mol Biol
; 434(2): 167395, 2022 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896364
9.
Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
Biochemistry
; 50(31): 6642-54, 2011 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21711014
10.
Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85alpha-p110alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors.
Protein Expr Purif
; 73(2): 167-76, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457255
11.
Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J Med Chem
; 62(4): 2154-2171, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30689376
12.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
13.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
J Med Chem
; 60(4): 1247-1261, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28151659
14.
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
J Med Chem
; 59(5): 2163-78, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26854747
15.
Conservation of Sox4 gene structure and expression during chicken embryogenesis.
Gene
; 320: 23-30, 2003 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-14597385
16.
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.
PLoS One
; 9(6): e98896, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24896564
17.
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.
ACS Med Chem Lett
; 4(12): 1238-43, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900635
18.
Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.
Chem Biol
; 18(2): 177-86, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21338916
19.
Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
J Med Chem
; 54(6): 1871-95, 2011 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21341675
20.
Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery.
ACS Med Chem Lett
; 1(8): 439-42, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900229