Detalhe da pesquisa
1.
Exploring the stability of ligand binding modes to proteins by molecular dynamics simulations.
J Comput Aided Mol Des
; 31(2): 201-211, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28074360
2.
Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.
Bioorg Med Chem
; 24(11): 2466-75, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117263
3.
Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
J Med Chem
; 65(4): 3343-3358, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35166541
4.
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).
J Med Chem
; 64(16): 12228-12244, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387987
5.
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.
Sci Rep
; 10(1): 17081, 2020 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33051477