Detalhe da pesquisa
1.
Phenotypic characteristics and immune response of Procypris merus following challenge with aquatic isolate of Klebsiella pneumoniae.
J Fish Dis
; 47(1): e13875, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37881099
2.
Changes in Chemical Composition of Flaxseed Oil during Thermal-Induced Oxidation and Resultant Effect on DSC Thermal Properties.
Molecules
; 27(20)2022 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36296728
3.
Heterologous Expression and Characterization of a Novel Exo-Polygalacturonase from Aspergillus fumigatus Af293 and Its Application in Juice Extraction.
J Microbiol Biotechnol
; 33(4): 533-542, 2023 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36788465
4.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.
Bioorg Med Chem Lett
; 22(11): 3699-703, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22560470
5.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides.
Bioorg Med Chem Lett
; 22(11): 3693-8, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22560473
6.
A Novel Endo-Polygalacturonase from Penicillium oxalicum: Gene Cloning, Heterologous Expression and Its Use in Acidic Fruit Juice Extraction.
J Microbiol Biotechnol
; 32(4): 464-472, 2022 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35001012
7.
Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg Med Chem Lett
; 20(9): 2828-31, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356737
8.
Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
Bioorg Med Chem Lett
; 18(1): 44-8, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18054488
9.
Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactions.
Protein Sci
; 14(7): 1818-26, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15937284
10.
Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease.
Antimicrob Agents Chemother
; 52(1): 110-20, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17938182
11.
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.
J Med Chem
; 51(17): 5243-63, 2008 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18690678
12.
Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.
Bioorg Med Chem Lett
; 17(8): 2250-3, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17289381
13.
Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
J Biol Chem
; 282(31): 22619-28, 2007 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17556358
14.
Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Bioorg Med Chem Lett
; 17(12): 3406-11, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17482818
15.
Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease.
Antimicrob Agents Chemother
; 50(3): 899-909, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16495249
16.
In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061.
J Biol Chem
; 280(44): 36784-91, 2005 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16087668
17.
Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob Agents Chemother
; 48(5): 1856-64, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15105144
18.
In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms.
J Biol Chem
; 279(17): 17508-14, 2004 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-14766754
19.
Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization.
Bioorg Med Chem Lett
; 14(6): 1441-6, 2004 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006379
20.
Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants.
Bioorg Med Chem Lett
; 13(22): 4059-63, 2003 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14592508