Detalhe da pesquisa
1.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature
; 575(7781): 217-223, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666701
2.
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals.
Toxicol Pathol
; 51(1-2): 81-86, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36695335
3.
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques.
Toxicol Pathol
; 50(5): 660-678, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35285336
4.
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat.
Toxicol Appl Pharmacol
; 423: 115578, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34004237
5.
Publication Categories in Toxicologic Pathology.
Toxicol Pathol
; 49(5): 1042-1047, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33576326
6.
Scientific and Regulatory Policy Committee Best Practices: Documentation of Sexual Maturity by Microscopic Evaluation in Nonclinical Safety Studies.
Toxicol Pathol
; 49(5): 977-989, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33661059
7.
Phosphatidylinositol 3-Kinase δ-Specific Inhibitor-Induced Changes in the Ovary and Testis in the Sprague Dawley Rat and Cynomolgus Monkey.
Int J Toxicol
; 40(4): 344-354, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33866838
8.
Nonclinical Safety Profile of Sotorasib, a KRASG12C-Specific Covalent Inhibitor for the Treatment of KRAS p.G12C-Mutated Cancer.
Int J Toxicol
; 40(5): 427-441, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34137282
9.
Phosphatidylinositol 3-Kinase δ Inhibitor-Induced Immunomodulation and Secondary Opportunistic Infection in the Cynomolgus Monkey (Macaca fascicularis).
Toxicol Pathol
; 48(8): 949-964, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252030
10.
Variability of Spleen and Mesenteric Lymph Node in Control Cynomolgus Monkeys ( Macaca fascicularis) from Nonclinical Safety Studies: A Retrospective Assessment.
Toxicol Pathol
; 47(1): 53-72, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30563426
11.
Maturity-related Variability of the Thymus in Cynomolgus Monkeys (Macaca fascicularis).
Toxicol Pathol
; 44(6): 874-91, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226125
12.
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious ß-secretase inhibitors for the potential treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 25(4): 767-74, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25613679
13.
Retinal Toxicity Induced by a Novel ß-secretase Inhibitor in the Sprague-Dawley Rat.
Toxicol Pathol
; 43(4): 581-92, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361751
14.
in silico transcriptome dissection of neocortical excitatory neurogenesis via joint matrix decomposition and transfer learning.
bioRxiv
; 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38464021
15.
Preservation of co-expression defines the primary tissue fidelity of human neural organoids.
bioRxiv
; 2023 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37034757
16.
Population variability in X-chromosome inactivation across 9 mammalian species.
bioRxiv
; 2023 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37904929
17.
OncoVEXmGM-CSFexpands tumor antigen-specific CD8+ T-cell response in preclinical models.
J Immunother Cancer
; 11(5)2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37164449
18.
Variability of cross-tissue X-chromosome inactivation characterizes timing of human embryonic lineage specification events.
Dev Cell
; 57(16): 1995-2008.e5, 2022 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35914524
19.
Strategies to evaluate potential effector function of glycan variants: a case study of ordesekimab (AMG 714 or PRV-015).
J Immunotoxicol
; 19(1): 109-116, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36083248
20.
Hallmarks of primary neurulation are conserved in the zebrafish forebrain.
Commun Biol
; 4(1): 147, 2021 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33514864