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1.
Conserv Genet ; 18(5): 983-994, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-32009857

RESUMO

Wildlife diseases are emerging at a higher rate than ever before meaning that understanding their potential impacts is essential, especially for those species and populations that may already be of conservation concern. The link between population genetic structure and the resistance of populations to disease is well understood: high genetic diversity allows populations to better cope with environmental changes, including the outbreak of novel diseases. Perhaps following this common wisdom, numerous empirical and theoretical studies have investigated the link between disease and disassortative mating patterns, which can increase genetic diversity. Few however have looked at the possible link between disease and the establishment of assortative mating patterns. Given that assortative mating can reduce genetic variation within a population thus reducing the adaptive potential and long-term viability of populations, we suggest that this link deserves greater attention, particularly in those species already threatened by a lack of genetic diversity. Here, we summarise the potential broad scale genetic implications of assortative mating patterns and outline how infection by pathogens or parasites might bring them about. We include a review of the empirical literature pertaining to disease-induced assortative mating. We also suggest future directions and methodological improvements that could advance our understanding of how the link between disease and mating patterns influences genetic variation and long-term population viability.

2.
Australas Phys Eng Sci Med ; 35(2): 237-43, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22678953

RESUMO

Physics quality assurance (QA) is an integral part of a medical physicist's role in the radiotherapy centre. Management of physics QA documents is an issue with a long-term accumulation. Storage space, archive administration and paper consumption are just some of the difficulties faced by physicists. Plotting trends and drawing meaningful conclusions from these results can be challenging using traditional QA methods. Remote checking of QA within a hospital network can also be problematic. The aim of this project is introduce a paperless QA system that will provide solutions to many of these issues.


Assuntos
Bases de Dados Factuais/normas , Documentação/normas , Física Médica/instrumentação , Física Médica/normas , Armazenamento e Recuperação da Informação/normas , Manutenção/normas , Garantia da Qualidade dos Cuidados de Saúde/normas , Austrália
3.
Parasitology ; 138(7): 858-65, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21554843

RESUMO

Drosophila melanogaster is an important model system of immunity and parasite resistance, yet most studies use parasites that do not naturally infect this organism. We have studied trypanosomatids in natural populations to assess the prevalence and diversity of these gut parasites. We collected several species of Drosophila from Europe and surveyed them for trypanosomatids using conserved primers for two genes. We have used the conserved GAPDH sequence to construct a phylogenetic tree and the highly variable spliced leader RNA to assay genetic diversity. All 5 of the species that we examined were infected, and the average prevalence ranged from 1 to 6%. There are several different groups of trypanosomatids, related to other monoxenous Trypanosomatidae. These may represent new trypanosomatid species and were found in different species of European Drosophila from different geographical locations. The detection of a little studied natural pathogen in D. melanogaster and related species provides new opportunities for research into both the Drosophila immune response and the evolution of hosts and parasites.


Assuntos
Drosophila/parasitologia , Variação Genética , Trypanosomatina/fisiologia , Animais , Análise por Conglomerados , Código de Barras de DNA Taxonômico , DNA Espaçador Ribossômico/genética , Interações Hospedeiro-Parasita , Dados de Sequência Molecular , Filogenia , RNA Líder para Processamento/genética , Trypanosomatina/classificação
4.
J Evol Biol ; 23(7): 1447-55, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20456575

RESUMO

Host-parasite coevolution is considered to be an important factor in maintaining genetic variation in resistance to pathogens. Drosophila melanogaster is naturally infected by the sigma virus, a vertically transmitted and host-specific pathogen. In fly populations, there is a large amount of genetic variation in the transmission rate from parent to offspring, much of which is caused by major-effect resistance polymorphisms. We have found that there are similarly high levels of genetic variation in the rate of paternal transmission among 95 different isolates of the virus as in the host. However, when we examined a transmission-blocking gene in the host, we found that it was effective across virus isolates. Therefore, the high levels of genetic variation observed in this system do not appear to be maintained because of coevolution resulting from interactions between this host gene and parasite genes.


Assuntos
Drosophila melanogaster/virologia , Variação Genética , Interações Hospedeiro-Patógeno/genética , Locos de Características Quantitativas , Rhabdoviridae/genética , Animais , Primers do DNA/genética , Feminino , Modelos Lineares , Masculino , Cadeias de Markov , Método de Monte Carlo
5.
Science ; 351(6273): 594-7, 2016 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-26912700

RESUMO

Deformed wing virus (DWV) and its vector, the mite Varroa destructor, are a major threat to the world's honeybees. Although the impact of Varroa on colony-level DWV epidemiology is evident, we have little understanding of wider DWV epidemiology and the role that Varroa has played in its global spread. A phylogeographic analysis shows that DWV is globally distributed in honeybees, having recently spread from a common source, the European honeybee Apis mellifera. DWV exhibits epidemic growth and transmission that is predominantly mediated by European and North American honeybee populations and driven by trade and movement of honeybee colonies. DWV is now an important reemerging pathogen of honeybees, which are undergoing a worldwide manmade epidemic fueled by the direct transmission route that the Varroa mite provides.


Assuntos
Abelhas/virologia , Interações Hospedeiro-Patógeno , Insetos Vetores/virologia , Vírus de Insetos/patogenicidade , Vírus de RNA/patogenicidade , Varroidae/virologia , Animais , Vírus de Insetos/classificação , Vírus de Insetos/isolamento & purificação , Filogenia , Vírus de RNA/classificação , Vírus de RNA/isolamento & purificação
6.
Heredity (Edinb) ; 98(4): 189-97, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17389895

RESUMO

Meiotic recombination is almost universal among sexually reproducing organisms. Because the process leads to the destruction of successful parental allele combinations and the creation of novel, untested genotypes for offspring, the evolutionary forces responsible for the origin and maintenance of this counter-intuitive process are still enigmatic. Here, we have used newly available genetic data to compare genome-wide recombination rates in a report on recombination rates among different taxa. In particular, we find that among the higher eukaryotes exceptionally high rates are found in social Hymenoptera. The high rates are compatible with current hypotheses suggesting that sociality in insects strongly selects for increased genotypic diversity in worker offspring to either meet the demands of a sophisticated caste system or to mitigate against the effects of parasitism. Our findings might stimulate more detailed research for the comparative study of recombination frequencies in taxa with different life histories or ecological settings and so help to understand the causes for the evolution and maintenance of this puzzling process.


Assuntos
Variação Genética , Insetos/genética , Recombinação Genética , Animais , Genoma , Genótipo , Reprodução , Comportamento Social , Vertebrados/genética
7.
Mol Ecol ; 16(6): 1327-39, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17391417

RESUMO

The genetic architecture of fitness-relevant traits in natural populations is a topic that has remained almost untouched by quantitative genetics. Given the importance of parasitism for the host's fitness, we used QTL mapping to study the genetic architecture of traits relevant for host-parasite interactions in the trypanosome parasite, Crithidia bombi and its host, Bombus terrestris. The three traits analysed were the parasite's infection intensity, the strength of the general immune response (measured as the encapsulation of a novel antigen) and body size. The genetic architecture of these traits was examined in three natural, unmanipulated mapping populations of B. terrestris. Our results indicate that the intracolonial phenotypic variation of all three traits is based on a network of QTLs and epistatic interactions. While these networks are similar between mapping populations in complexity and number of QTLs, as well as in their epistatic interactions, the variability in the position of QTL and the interacting loci was high. Only one QTL for body size was plausibly found in at least two populations. QTLs for encapsulation and Crithidia infection intensity were located on the same linkage groups.


Assuntos
Abelhas/genética , Abelhas/parasitologia , Crithidia/genética , Variação Genética , Genética Populacional , Fenótipo , Animais , Abelhas/imunologia , Tamanho Corporal/genética , Crithidia/patogenicidade , Epistasia Genética , Feminino , Interações Hospedeiro-Parasita , Masculino , Locos de Características Quantitativas
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