Pesquisa | BVS Violência e Saúde

1.

Chemically defined cytokine-free expansion of human haematopoietic stem cells.

Sakurai, Masatoshi; Ishitsuka, Kantaro; Ito, Ryoji; Wilkinson, Adam C; Kimura, Takaharu; Mizutani, Eiji; Nishikii, Hidekazu; Sudo, Kazuhiro; Becker, Hans Jiro; Takemoto, Hiroshi; Sano, Tsubasa; Kataoka, Keisuke; Takahashi, Satoshi; Nakamura, Yukio; Kent, David G; Iwama, Atsushi; Chiba, Shigeru; Okamoto, Shinichiro; Nakauchi, Hiromitsu; Yamazaki, Satoshi.

Nature ; 615(7950): 127-133, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36813966

2.

Haematopoietic stem cell self-renewal in vivo and ex vivo.

Wilkinson, Adam C; Igarashi, Kyomi J; Nakauchi, Hiromitsu.

Nat Rev Genet ; 21(9): 541-554, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32467607

3.

Author Correction: Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Wilkinson, Adam C; Ishida, Reiko; Kikuchi, Misako; Sudo, Kazuhiro; Morita, Maiko; Crisostomo, Ralph Valentine; Yamamoto, Ryo; Loh, Kyle M; Nakamura, Yukio; Watanabe, Motoo; Nakauchi, Hiromitsu; Yamazaki, Satoshi.

Nature ; 571(7766): E12, 2019 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-31289376

4.

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Wilkinson, Adam C; Ishida, Reiko; Kikuchi, Misako; Sudo, Kazuhiro; Morita, Maiko; Crisostomo, Ralph Valentine; Yamamoto, Ryo; Loh, Kyle M; Nakamura, Yukio; Watanabe, Motoo; Nakauchi, Hiromitsu; Yamazaki, Satoshi.

Nature ; 571(7763): 117-121, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31142833

5.

Identification and characterization of in vitro expanded hematopoietic stem cells.

Che, James L C; Bode, Daniel; Kucinski, Iwo; Cull, Alyssa H; Bain, Fiona; Becker, Hans J; Jassinskaja, Maria; Barile, Melania; Boyd, Grace; Belmonte, Miriam; Zeng, Andy G X; Igarashi, Kyomi J; Rubio-Lara, Juan; Shepherd, Mairi S; Clay, Anna; Dick, John E; Wilkinson, Adam C; Nakauchi, Hiromitsu; Yamazaki, Satoshi; Göttgens, Berthold; Kent, David G.

EMBO Rep ; 23(10): e55502, 2022 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-35971894

6.

Establishment of mouse expanded potential stem cells.

Yang, Jian; Ryan, David J; Wang, Wei; Tsang, Jason Cheuk-Ho; Lan, Guocheng; Masaki, Hideki; Gao, Xuefei; Antunes, Liliana; Yu, Yong; Zhu, Zhexin; Wang, Juexuan; Kolodziejczyk, Aleksandra A; Campos, Lia S; Wang, Cui; Yang, Fengtang; Zhong, Zhen; Fu, Beiyuan; Eckersley-Maslin, Melanie A; Woods, Michael; Tanaka, Yosuke; Chen, Xi; Wilkinson, Adam C; Bussell, James; White, Jacqui; Ramirez-Solis, Ramiro; Reik, Wolf; Göttgens, Berthold; Teichmann, Sarah A; Tam, Patrick P L; Nakauchi, Hiromitsu; Zou, Xiangang; Lu, Liming; Liu, Pentao.

Nature ; 550(7676): 393-397, 2017 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-29019987

7.

Take the MYC to expand blood stem cells.

Wilkinson, Adam C.

Blood ; 143(10): 838-840, 2024 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-38451515

8.

In vivo and ex vivo haematopoietic stem cell expansion.

Yamamoto, Ryo; Wilkinson, Adam C; Nakauchi, Hiromitsu.

Curr Opin Hematol ; 27(4): 273-278, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32452877

9.

Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model.

Wilson, Nicola K; Schoenfelder, Stefan; Hannah, Rebecca; Sánchez Castillo, Manuel; Schütte, Judith; Ladopoulos, Vasileios; Mitchelmore, Joanna; Goode, Debbie K; Calero-Nieto, Fernando J; Moignard, Victoria; Wilkinson, Adam C; Jimenez-Madrid, Isabel; Kinston, Sarah; Spivakov, Mikhail; Fraser, Peter; Göttgens, Berthold.

Blood ; 127(13): e12-23, 2016 Mar 31.

Artigo em Inglês | MEDLINE | ID: mdl-26809507

10.

Branched-chain amino acid metabolism in cancer.

Ananieva, Elitsa A; Wilkinson, Adam C.

Curr Opin Clin Nutr Metab Care ; 21(1): 64-70, 2018 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-29211698

11.

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification.

Wilkinson, Adam C; Kawata, Viviane K S; Schütte, Judith; Gao, Xuefei; Antoniou, Stella; Baumann, Claudia; Woodhouse, Steven; Hannah, Rebecca; Tanaka, Yosuke; Swiers, Gemma; Moignard, Victoria; Fisher, Jasmin; Hidetoshi, Shimauchi; Tijssen, Marloes R; de Bruijn, Marella F T R; Liu, Pentao; Göttgens, Berthold.

Development ; 141(20): 4018-30, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-25252941

12.

CODEX: a next-generation sequencing experiment database for the haematopoietic and embryonic stem cell communities.

Sánchez-Castillo, Manuel; Ruau, David; Wilkinson, Adam C; Ng, Felicia S L; Hannah, Rebecca; Diamanti, Evangelia; Lombard, Patrick; Wilson, Nicola K; Gottgens, Berthold.

Nucleic Acids Res ; 43(Database issue): D1117-23, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25270877

13.

Ex vivo hematopoietic stem cell expansion technologies: recent progress, applications, and open questions.

Meaker, Grace A; Wilkinson, Adam C.

Exp Hematol ; 130: 104136, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38072133

14.

Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors.

Suchy, Fabian P; Karigane, Daiki; Nakauchi, Yusuke; Higuchi, Maimi; Zhang, Jinyu; Pekrun, Katja; Hsu, Ian; Fan, Amy C; Nishimura, Toshinobu; Charlesworth, Carsten T; Bhadury, Joydeep; Nishimura, Toshiya; Wilkinson, Adam C; Kay, Mark A; Majeti, Ravindra; Nakauchi, Hiromitsu.

Nat Biotechnol ; 2024 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-38589662

15.

Transcriptional regulation of haematopoietic stem cells.

Wilkinson, Adam C; Göttgens, Berthold.

Adv Exp Med Biol ; 786: 187-212, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23696358

16.

Ex Vivo Expansion and Genetic Manipulation of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Cultures.

Khoo, Hwei Minn; Meaker, Grace A; Wilkinson, Adam C.

J Vis Exp ; (192)2023 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-36847389

17.

In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation.

Bozhilov, Yavor K; Hsu, Ian; Brown, Elizabeth J; Wilkinson, Adam C.

Cells ; 12(6)2023 03 14.

Artigo em Inglês | MEDLINE | ID: mdl-36980237

18.

Exploiting somatic mutations to decipher human blood production: a natural lineage-tracing strategy.

Bloom, Mackenzie; Malouf, Camille; Rodriguez-Fraticelli, Alejo; Wilkinson, Adam C; Sankaran, Vijay G; Cvejic, Ana.

Exp Hematol ; 121: 2-5, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36736573

19.

Predictors of pituitary tumour behaviour: an analysis from long-term follow-up in 2 tertiary centres.

Lenders, Nèle F; Earls, Peter E; Wilkinson, Adam C; Costin, Monique; Hofer, Monika; Shein, Tint T; Harvey, Richard J; Krishnan, Gayathri; Picallo, Maria; Pal, Aparna; Wass, John; McCormack, Ann I.

Eur J Endocrinol ; 189(1): 106-114, 2023 Jul 20.

Artigo em Inglês | MEDLINE | ID: mdl-37461224

20.

Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion.

Becker, Hans Jiro; Ishida, Reiko; Wilkinson, Adam C; Kimura, Takaharu; Lee, Michelle Sue Jann; Coban, Cevayir; Ota, Yasunori; Tanaka, Yosuke; Roskamp, Meike; Sano, Tsubasa; Tojo, Arinobu; Kent, David G; Yamazaki, Satoshi.

Cell Stem Cell ; 30(7): 987-1000.e8, 2023 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-37385251

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