When to Schedule Your Next COVID-19 Vaccine.

We would like to share our ideas on the article, "When Should I Get My Next COVID-19 Vaccine? Data From the Surveillance of Responses to COVID-19 Vaccines in Systemic Immune-Mediated Inflammatory Diseases (SUCCEED) Study."1 In this investigation, data and dried blood spots/sera were obtained from adults with a range of inflammatory diseases following coronavirus disease 2019 (COVID-19) vaccination.

Comment on published article "A chat about bipolar disorder".

To the Editor, we follow the topic "A chat about bipolar disorder1 ". According to the study's findings, ChatGPT proved its ability to deliver basic and informative information on bipolar disorders.

Orf, a Human Parapoxvirus Infection.

Despite being common worldwide, parapoxvirus infections are regarded as neglected zoonoses because their incidence is either unknown or grossly overestimated. In ruminants all throughout the world, parapoxvirus produces oral lesions and infectious pustular dermatitis. The pathogen is typically spread directly via items contaminated with parapoxvirus and indirectly via a near contact with dermatological lesions that contain the virus on affected animals. Animals infected with the parapoxvirus typically exhibit no clinical symptoms, and the mode of parapoxvirus transmission is occasionally unclear. For accurate etiological diagnosis and appropriate therapy of patients affected by zoonotic infections, the significance of adopting a "One Health" approach and cross-sector collaboration between human and veterinary medicine should be emphasized. The causative pathogen of ecthyma contagiosum in general people is the orf virus, which mostly infects various animals, either pets or wildlife species. The illness primarily affects minute wild ruminants, sheep, cattle, deer, and goats, and it can spread to people through contact with infected animals or contaminated meats anywhere in the world. Taxonomically speaking, the virus belongs to the parapoxvirus genus. Thus pathogen can be detected from crusts for a very long period (several months to several years), and the virus is found to be resistant to inactivation with a hot or dry atmosphere. In immunocompetent individuals, the lesions often go away on their own with a period as long 2 months. Nevertheless, it necessitates the applying of diverse strategies, such as antiviral, immunological modulator, or modest surgical excisions in immunosuppressed patients. The interaction of the virus with various host populations aids in the development of a defense mechanism against the immune system. The parapoxvirus illness in humans is covered in this chapter. The orf illness, a significant known human parapoxvirus infection, is given specific attention.

ChatGPT and Gemini large language models for pharmacometrics with NONMEM: comment.

This is a correspondence on "Evaluation of ChatGPT and Gemini large language models for pharmacometrics with NONMEM". Additional concern on using ChatGPT and Gemini is provided.

AI in the repurposing of potential herbs for filariasis therapy.

BACKGROUND OBJECTIVES: The goal of this study was to see how well an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) assisted healthcare personnel in selecting relevant medications for filariasis therapy. A team of medical specialists and tropical medicine experts reviewed ChatGPT's recommendations for ten hypothetical filariasis clinical situations. METHODS: The purpose of this study was to look at the effectiveness of an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) in supporting healthcare providers in picking appropriate drugs for filariasis treatment. Ten hypothetical filariasis clinical cases were submitted to ChatGPT, and its recommendations were evaluated by a panel of medical professionals and tropical medicine experts. RESULTS: ChatGPT gave appropriate suggestions for potential medication repurposing in filariasis treatment in all ten clinical scenarios. Its drug recommendations were in line with current medical research and literature. Despite the lack of particular treatment regimens, ChatGPT's general ideas proved useful for healthcare practitioners, providing insights and updates on prospective drug repurposing tactics. INTERPRETATION CONCLUSION: ChatGPT shows promise as a useful method for repurposing drugs in the treatment of filariasis. Its thorough and brief responses make it useful for finding possible pharmacological candidates. However, it is critical to recognize ChatGPT's limitations, such as the requirement for additional clinical information and the inability to change therapy. Further research and development are required to optimize its use in filariasis therapy settings.

Digital Technology in Clinical Medicine: Correspondence.

We found the article on "The Digital Technology in Clinical Medicine: From Calculators to ChatGPT" interesting.1 According to Kulkarni et al., humanity has witnesses four important social system changes, starting with the primitive huntersgatherers and progressing to horticultural, agricultural, industrial, and the current fifth, which is based on digital information technology and has altered the way we present, recognize, and utilize different factors of production. In clinical medicine, digital technology has advanced significantly since the days of computations. According to Kulkarni et al., we have to benefit from these advancements as we all improve the lives of our patients while being cautious not to overturn the doctor-patient relationship. If technology, clinical expertise, and humanistic values are properly balanced, Kulkarni et al. concluded that the future is quite glorious.1 Regulatory organizations are pushing for improvements through clinical trials as a result of recognition of the expanding influence of digital technology in healthcare delivery. The "World Health Organizations Guidelines for Digital Interventions" and the "Food and Drug Administration's Digital Health Center of Excellence" are only two of the projects that are currently being highlighted in the study as efforts to analyze and implement digital health services.

ChatGPT in Trauma Triage.

How to cite this article: Mungmunpuntipantip R, Wiwanitkit V. ChatGPT in Trauma Triage. Indian J Crit Care Med 2024;28(6):617.

Monkeypox and Sexually Transmitted Diseases.

Monkeypox is a unique variety of pox infection. Despite being around for a long time, there hasn't been a large outbreak of this disease. WHO has already acknowledged the seriousness of the large monkeypox outbreak in 2022. Africa's unusual outbreak outside of endemic regions is a problem. Numerous observations have been made about the new clinical epidemiological pattern. Human monkeypox is currently spreading outside of endemic African countries, and the majority of those affected are gay and bisexual men in linked sexual networks. As was already mentioned, the current public health concern is the spread of monkeypox through sexual contact. The link between monkeypox and other sexually transmitted diseases is a growing concern because it is believed that the disease can be transferred through sexual contact. This page provides a summary of the interactions between other significant STDs such as HIV infection, syphilis, and gonorrhea. A fascinating research topic at the moment is the connection between monkeypox and other sexually transmitted diseases.

Laboratory Diagnosis for Monkeypox: Clinical Practice and Important Points to Be Recognized.

Monkeypox is a unique variety of pox infection. WHO has already acknowledged the seriousness of the large monkeypox outbreak in 2022. The disease commonly presents as acute febrile illness with skin lesion. However, a fever or a skin lesion, however, is sometimes not detectable. Without the peculiar appearance, the physician might have missed the problem and made a false diagnosis. Basically, the clinical diagnosis is the simplest procedure and must be used by practitioners. Laboratory methods can help confirm diagnosis. The gold standard for diagnosis is the molecular-based diagnosis. There are also other available approaches such as point of care testing. In this article, we also summarize and discuss important practical points in laboratory diagnosis for monkeypox.

Superspreading event of Covid-19 in adolescents and vaccination: correspondence.

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Guillain-Barré Syndrome Following the mRNA COVID-19 Vaccination: Comment.

Dear Editor, we would like to share ideas on the publication "Guillain-Barré Syndrome Following the BNT162b2 mRNA COVID-19 Vaccine [1]." In order to advance our understanding of this consequence, Algahtani et al. describe a case of Guillain-Barré syndrome following the first dose of the BNT162b2 mRNA COVID-19 vaccination [1]. Guillain-Barré syndrome following COVID-19 vaccination is treatable, according to Algahtani et al. [1]. The advantages of providing the vaccination exceed the dangers, according to Algahtani et al. [1]. Algahtani and co. mentioned Given the detrimental effects of COVID-19, it is crucial to be aware of the emergence of any potential neurological side effects after immunization, such as Guillain-Barré syndrome [1]. We can all agree that COVID-19 prevention is essential and that additional research is required to address the underlying clinical problem. The outcome of a vaccination test and the development of a clinical condition may be related. Prior to treating the clinical issues caused by COVID-19 vaccination, a few crucial aspects need to be taken into account Comorbidities should be taken into account first. For instance, when the sickness and the clinical state co-occur, dengue vaccinations may be employed. Early detection of asymptomatic COVID-19 individuals is crucial [2]. It's likely that prior COVID-19 epidemics affected the effectiveness and outcomes of the immunization. Infection with COVID-19 may have an impact on clinical outcomes. Without the necessary laboratory testing, it can be difficult to completely rule out an illness that was previously asymptomatic. A significant auxiliary influence is genetics [3]. The immune system's reaction to specific hereditary features may have an impact on how it reacts to the negative side effects of vaccination. Understanding how underlying genetic variables affect vaccine efficacy in clinical settings would be highly beneficial. In fact, more research is required to find a solution to this problem. The volume of clinical information needed will aid in researchers' knowledge.

SARS-CoV-2 vaccination in inflammatory bowel disease patients with different biological agents: correspondence.

We would like to discuss "Impact of SARS-CoV-2 vaccination in inflammatory bowel disease patients with different biological agents: a systematic review and meta-analysis". The serological responses, breakthrough infections, and clinical relapse of IBD patients treated with biological drugs after SARS-CoV-2 immunization were the subject of a thorough study and meta-analysis. The total seroconversion rate following SARS-CoV-2 immunization in IBD patients receiving biological therapy is high, according to Dai et al. In IBD patients receiving biological therapy, the overall rate of breakthrough infections and the rate of clinical recurrence were both low.

COVID-19 Vaccine Associated with Cutaneous Involvement: Correspondence.

How to cite this article: Mungmunpuntipantip R, Wiwanitkit V. COVID-19 Vaccine Associated with Cutaneous Involvement: Correspondence. Indian J Crit Care Med 2023;27(8):599.

COVID-19 and favipiravir induce cutaneous adverse reactions: a difficulty in clinical dermatology practice.

There have been reports of skin rash developing in patients with COVID-19 on favipiravir therapy, including a recent report in this journal. We report a patient who developed a maculopapular skin rash while taking favipiravir.

Giant cell vasculitis post-COVID-19 mRNA vaccine and COVID-19 asymptomatic infection: Correspondence.

The possible adverse effect of COVID-19 vaccine is interesting. This correspondence discussed on the case of Giant cell vasculitis post-COVID-19 mRNA vaccine. The possible effect of the COVID-19 asymptomatic infection is highlighted.

Variability in case fatality rate risk due to Covid-19 and health services provider.

Not available.

Comments on "Identifying psychological antecedents and predictors of vaccine hesitancy through machine learning: A cross sectional study among chronic disease patients of deprived urban neighbourhood, India".

Dear Editor, we read the publication by Rustagi et al. "Identifying psychological antecedents and predictors of vaccine hesitancy through machine learning: A cross sectional study among chronic disease patients of deprived urban neighbourhood, India" with a great interest...

Monkeypox Virus Detection and Deep Learning-based Approaches: Correspondence.

This letter to the editor discusses the publication of a paper on monkeypox virus detection and deep learning-based approaches. Confounding issues regarding diagnosis are discussed.

Diarrhea and monkeypox: a consideration.

In addition to the well-known pox infections, novel zoonotic pox diseases have emerged as a severe concern in infectious medicine. In May 2022, monkeypox has already been reported in many countries in Europe, creating a significant public health risk possibility. Human-to-human transfer is being researched right now. As the number of reported cases in various countries climbs, the medical community is concerned, and proper preparation is required.

COVID-19 vaccine and autoimmune hepatitis.

We would like to correspond and share ideas on the publication "SARS-CoV-2 vaccine, a new autoimmune hepatitis trigger?." López Romero-Salazar reported a case of autoimmune hepatitis (AIH) after receiving SARS-COV2 vaccine. López Romero-Salazar et al noted that "vaccination can induce the development of autoimmune pathology in patients at risk." The possibility of a link between AIH and the SARS-CoV2 vaccine is explored. We agree that the COVID-19 vaccination has the potential to create clinical problems. The aberrant immune response could lead to a variety of health issues, including hepatitis. The vaccine recipient in this case had hepatitis, but there is no information about his or her health or liver function prior to inoculation. Other probable causes of hepatitis should be considered.