Interface Dipole Management of D-A-Type Molecules for Efficient Perovskite Solar Cells.

Interfacial engineering of perovskite films has been the main strategies in improving the efficiency and stability of perovskite solar cells (PSCs). In this study, three new donor-acceptor (D-A)-type interfacial dipole (DAID) molecules with hole-transporting and different anchoring units are designed and employed in PSCs. The formation of interface dipoles by the DAID molecules on the perovskite film can efficiently modulate the energy level alignment, improve charge extraction, and reduce non-radiative recombination. Among the three DAID molecules, TPA-BAM with amide group exhibits the best chemical and optoelectrical properties, achieving a champion PCE of 25.29 % with the enhanced open-circuit voltage of 1.174 V and fill factor of 84.34 %, due to the reduced defect density and improved interfacial hole extraction. Meanwhile, the operational stability of the unencapsulated device has been significantly improved. Our study provides a prospect for rationalized screening of interfacial dipole materials for efficient and stable PSCs.

Self-Polymerized Spiro-Type Interfacial Molecule toward Efficient and Stable Perovskite Solar Cells.

In the pursuit of highly efficient perovskite solar cells, spiro-OMeTAD has demonstrated recorded power conversion efficiencies (PCEs), however, the stability issue remains one of the bottlenecks constraining its commercial development. In this study, we successfully synthesize a novel self-polymerized spiro-type interfacial molecule, termed v-spiro. The linearly arranged molecule exhibits stronger intermolecular interactions and higher intrinsic hole mobility compared to spiro-OMeTAD. Importantly, the vinyl groups in v-spiro enable in situ polymerization, forming a polymeric protective layer on the perovskite film surface, which proves highly effective in suppressing moisture degradation and ion migration. Utilizing these advantages, poly-v-spiro-based device achieves an outstanding efficiency of 24.54 %, with an enhanced open-circuit voltage of 1.173 V and a fill factor of 81.11 %, owing to the reduced defect density, energy level alignment and efficient interfacial hole extraction. Furthermore, the operational stability of unencapsulated devices is significantly enhanced, maintaining initial efficiencies above 90 % even after 2000 hours under approximately 60 % humidity or 1250 hours under continuous AM 1.5G sunlight exposure. This work presents a comprehensive approach to achieving both high efficiency and long-term stability in PSCs through innovative interfacial design.

Blue, green, and grey water footprints assessment for paddy irrigation-drainage system.

Water footprint (WF) quantifies the impact of paddy field evapotranspiration (ET) and non-point source pollution on water resources and is an evaluation index for water sustainability. However, it is difficult to measure accurately using the existing method, which is based on parameter assumption without considering the field water conditions. In this study, a generic and physically based method for blue, green, and grey water accounting in paddy rice cultivation is introduced. We conducted field experiments using the common flood irrigation (CFI) and water-saving irrigation (SWI) modes in Nanjing, East China. By tracing the sources of ET and the migration process of multiple pollutants (TN, TP, NH4+-N, and NO3--N), the characteristics of blue-green water consumption and the actual amount of water required to dilute pollutants at different growth stages of rice under CFI and SWI were analyzed. The WF of paddy rice was 1000 m3/t (49% WFgreen, 17% WFblue, 34% WFgrey) and 910 m3/t (50% WFgreen, 10% WFblue, 40% WFgrey) for CFI and SWI, respectively. The WF for paddy rice production was reduced by approximately 9% under SWI compared to CFI, with declines of 47% for WFblue and 8% for WFgreen. The SWI mode changed the ratio of blue to green water fluxes in field water by reducing irrigation during non-critical periods, and green water was used preferentially to enhance its utility. This conceptual method is the first to describe the formation mechanism of blue, green, and grey WFs in paddy systems. It can be extended to different scales and agro-ecosystems that show the influence of crop cultivation on water resources.

Analysis of the characteristics and driving forces of water footprint productivity in paddy rice cultivation in China.

BACKGROUND: Water productivity improvement is fundamental to agricultural water use control, and the water footprint provides a new and comprehensive method for identifying the crop-water relationship. This study is intended to explore the spatiotemporal pattern and driving forces underlying the rice water footprint productivity (WFP) in China during the years 1996-2015 based on calculations of the provincial blue, green, gray, and white water footprints. RESULTS: The national water footprint in paddy rice cultivation was 240.97 Gm3 , and green water accounted for 43.9% of the total. The WFP was 0.795 kg m-3 and increased over time in all 30 provinces for which it was calculated. The growth rate in the northern provinces was greater than that in the southern part of the country. The WFP clustered geographically in all years observed. High-value provinces were concentrated to the south of the Yangtze River, whereas most of the provinces that showed a low WFP were distributed in the north China and northwest subregions. Precipitation and sunshine hours were the most obvious driving factors of rice WFP. The effects of agricultural input, e.g., agricultural machinery power, pesticides, and irrigation efficiency, on WFP also could not be ignored. CONCLUSION: The WFP is a comprehensive and useful index of the crop-water relationship and water-use efficiency. Improving agricultural input and irrigation technology are reliable approaches for WFP promotion. Areas in northeast China showed the most urgent need for improving the rice WFP, and the inclusion of the main grain producing areas in the Yangtze River Basin will further reduce ineffective water occupancy to improve water-use efficiency. © 2019 Society of Chemical Industry.

Enhanced drought tolerance of foxtail millet seedlings by sulfur dioxide fumigation.

Recently, sulfur dioxide (SO2) has been considered to be a beneficial bio-regulator in animals. However, the positive roles of SO2 in plant adaptation to drought stress are still unclear. In this study, we investigated the physiological and molecular changes that are induced by SO2 fumigation to improve the drought tolerance of foxtail millet seedlings. The relative water content in the leaves of drought-stressed seedlings was significantly improved by pre-exposure to 30 mg/m3 SO2. These responses might be related to decreased stomatal apertures and a reduced leaf transpiration rate, which were induced by SO2 under drought conditions. In addition, the SO2 pretreatment markedly enhanced proline accumulation in the leaves of drought-stressed seedlings, which was supported by increased Δ1-pyrroline-5-carboxylate synthetase (P5CS) activity, decreased proline dehydrogenase (ProDH) activity, and the corresponding transcripts. Moreover, the SO2 application upregulated the enzyme activity of catalase (CAT) and peroxidase (POD) in the leaves of drought-stressed plants, as well as their transcripts, which contributed to the scavenging of hydrogen peroxide (H2O2) and alleviated drought-induced oxidative damage, as indicated by the decreased malondialdehyde (MDA) level in SO2-pretreated plants. Together, these results indicate that the application of SO2 might enhance drought tolerance by reducing stomatal apertures, increasing proline accumulation, and promoting antioxidant defence in foxtail millet seedlings. This study presents new insight into the beneficial roles of SO2 in plant responses to drought stress.

Sulfur dioxide derivatives alleviate cadmium toxicity by enhancing antioxidant defence and reducing Cd2+ uptake and translocation in foxtail millet seedlings.

Sulfur dioxide (SO2) was recently proposed as a novel bio-regulator in mammals. However, the possible advantageous effects of SO2 in plant adaptation to heavy metal-contaminated environments are largely unknown. In the present study, using Na2SO3/NaHSO3 derivatives as SO2 donors, we investigated the possible roles and regulation mechanisms of SO2 in alleviating Cd2+ toxicity in foxtail millet seedlings. Exogenous SO2 derivatives (0.5 mM) application significantly reduced the seedling growth inhibition caused by Cd2+ stress. Cd2+-induced oxidative damage was also alleviated by SO2 derivatives, which was supported by the decreased malondialdehyde (MDA) level in the leaves of seedlings pretreated with SO2 derivatives. These responses were related to the enhanced activities of representative antioxidant enzymes, including catalase and superoxide dismutase, as well as the up-regulation of ascorbate-glutathione cycle, which contributed to the scavenging of Cd2+-elicited O2•－ and H2O2 within the leaves of foxtail millet seedlings. Also, SO2 derivative application promoted sulfur assimilation and increased the content of glutathione and phytochelatins, which may help to enhance Cd2+ detoxification capacity in foxtail millet seedlings. Moreover, application of SO2 derivatives caused down-regulation of the transcript expression levels of several genes involved in Cd2+ uptake and translocation, such as NRAMP1, NRAMP6, IRT1, IRT2, HMA2, and HMA4, thus resulting in reduced Cd2+ accumulation in the shoots and roots of Cd2+-stressed seedlings. Collectively, these results suggest that exogenous SO2 derivative application can alleviate oxidative damage and restrict Cd2+ buildup, thereby reducing Cd2+-induced growth inhibition in foxtail millet seedlings upon Cd2+ exposure. This novel finding indicates that the usage of SO2 derivatives may be an effective approach for enhancing Cd2+ tolerance in foxtail millet and other crops.

Changes and predictors of mental health of Chinese university students after the COVID-19 pandemic: A two-year study.

BACKGROUND: Psychological repurcussions of COVID-19 pandemic has received wide attention, but there's limited attention paid to psychological recovery afterwards. This study focuses on the changes and predictive factors of mental health of Chinese university students post-pandemic. METHODS: This study included 1175 Chinese undergraduate students sampled in May 2022 and May-June 2023, right before and after peaks of infections following the end of lockdown policy in China. The participants completed a survey of demographic variables, and three questionnaires: 12-item General Health Questionnaire, Positive Psychological Capital Questionnaire, and Prosocial Tendencies Measure. RESULTS: The participants sampled in 2023 have significant lower GHQ scores and higher PPQ scores than those sampled in 2022, while there is no significant difference in PTM scores between them. The proportion of participants with GHQ-12 scores exceeding 12 in 2023 showed slightly decrease compared to that in 2022. The infection of significant others, the sense of hope, and PPQ self-efficiency, hope and optimism subscale scores were significantly associated with GHQ-12 scores in 2023, but actual infection or quarantine experience were not. CONCLUSIONS: The mental health and psychological capital of the university students have been significantly improved within a year. It is worthy to pay attention to the infection of significant others, the sense of hope, and psychological capital in a pandemic to improve the mental health of university students. LIMITATIONS: Compared to a cross-sectional study, longitudinal research is the better choice for a two-year comparison.

Monitoring grey water footprint and associated environmental controls in agricultural watershed.

The grey water footprint (GWF) is an advanced index linking pollution load and water resources. However, the existing agriculture-related GWF was developed based on hydrological processes, which limits its role in watershed water pollution level (WPL) measurements. The main scope of this study is to calculate GWF and WPL based on runoff, total nitrogen (TN), and total phosphorus (TP) observations in the Hujiashan Watershed of China's Yangtze River Basin. Partial least squares structural equation modeling (PLS-SEM) was utilized to explore the impact pathways of environmental features on GWF and WPL. On this basis, propose measures for the management of this agricultural watershed. The results showed that the TN concentration had a V-shaped trend in 2008-2015, while the TP gradually decreased. The GWF calculations for the TN and TP were compatible with the temporal trends for the concentrations, which were higher in the wet season (0.45 m3/m2 for TN, 0.10 m3/m2 for TP) than in the dry season (0.11 m3/m2 for TN, 0.02 m3/m2 for TP) and increased from upstream to downstream. The WPLs of TN exceeded 2.0 in the midstream and downstream areas, whereas those for TP were inconspicuous. According to PLS-SEM, the GWF is primarily influenced by topographical variables and hydrological features, whereas the WPL is mainly controlled by hydrological features and landscape composition. Fertilizer reduction and efficiency measures should be implemented on farmland and appropriately reducing farming activities on slopes to relieve the GWF and WPL in the watershed.

Exogenous salicylic acid induces defense responses in tea plants against Toxoptera aurantii (Hemiptera: Aphididae).

Toxoptera aurantii is one of the most destructive pests, threatening the yield and quality of tea plantations. The salicylic acid (SA)-mediated signaling pathway is vital for the induction of plant defense responses; however, its role in tea plant resistance to T. aurantii remains unclear. Thus, this study used and electrical penetration graph and monitoring of population dynamics to evaluate the effects of exogenous SA application on T. aurantii feeding behavior and population growth in tea seedlings. Moreover, the effects of SA treatment on the activities of defense-related enzymes were analyzed. Probe counts and the duration of xylem sap ingestion were significantly higher in SA-treated plants than those in the control group. The total duration of passive phloem ingestion was significantly decreased in 0.5 mmol/l SA-treated plants, and the application of 0.5, 1, and 4 mmol/l SA significantly inhibited T. aurantii population growth. In addition, the activities of polyphenol oxidase, peroxidase, and superoxide dismutase were significantly increased in the 0.5 mmol/l SA-treated plants. Overall, this study demonstrates the capacity of exogenous SA to activate defense responses against T. aurantii. These results have crucial implications for understanding the mechanisms of enhanced resistance, thereby providing a sustainable approach for managing T. aurantii.

An integrated framework for improving green agricultural production sustainability in human-natural systems.

Water scarcity, land pollution, and global warming are serious challenges and crises facing the development of sustainable or green agriculture and need to be addressed using efficient and environmentally friendly management strategies. This paper proposed an integrated framework appropriate for agricultural green total factor productivity (AGTFP) assessment coupled with microscopic and mesoscopic perspectives under water-energy-food (WEF) nexus, which generated scientific and reasonable strategies for green and low-carbon agriculture from internal core factors and peripheral environmental impacts to improve green agricultural production sustainability. Taking the Lianshui irrigation district (LID) with three sub-areas as the object, internal core factors were explored by partial least squares regression (PLSR) and the external impact path through partial least squares structural equation modeling (PLS-SEM). Results indicated that AGTFP in LID was the smallest (0.818) compared to the three sub-areas and was in a fluctuating state. Meanwhile, AGTFP which was calculated considering undesirable outputs, was closer to tangible productivity. Resource endowments and technical facilities will promote agricultural production, desirable outputs will stimulate green production, and undesirable outputs can inhibit green production. The external influence pathway was shown to be primary environment - > secondary environment - > economic aspects - > social aspects - > AGTFP. The innovative perspectives presented in this study can facilitate preferable decisions and avoid unintended consequences for human-natural systems.

Self-healing, antibacterial, and conductive double network hydrogel for strain sensors.

Multifunctional hydrogels have great potential in smart wearable technology, flexible electronic devices, and biomedical research. However, it is highly challenging to prepare unique conductive hydrogels with combined properties such as self-healing, self-adhesive, and antibacterial activity. In this regard, herein, a conductive double network hydrogel (ACBt-PAA/CMCs) was fabricated using carboxymethyl chitosan (CMCs), acrylic acid (AA), and alkaline calcium bentonite (ACBt) via a convenient approach. Owing to the hydrogen bond interaction between PAA and CMCs, the ACBt-PAA/CMCs double network structured hydrogels exhibited excellent self-healing (the tensile strength recovered to 74.3 % after 1 h) and adjustable mechanical properties, in which the fracture stress and strain can be easily adjusted in the range of 0.039 to 0.93 MPa and 564 to 2900 %, respectively. In addition, the ACBt-PAA/CMCs hydrogels exhibited the remarkable antibacterial activities against Escherichia coli (bacterial inhibition efficiency of ~99.99 %) and Staphylococcus aureus (bacterial inhibition efficiency of ~99.98 %). Furthermore, the ACBt-PAA/CMCs hydrogel based wearable skin exhibited an excellent real-time sensing performance for monitoring various motions, signifying outstanding sensing and self-adhesion properties. Considering the unique features such as self-healing, excellent adhesion, highly active strain sensing, and antibacterial activities making the ACBt-PAA/CMCs hydrogel is an excellent multifunctional conductive hydrogel. Hence, we believe that this proposed design method for the fabrication of smart and multifunctional conductive hydrogels, and this ACBt-PAA/CMCs hydrogel could be a promising candidate for flexible wearable materials, health monitoring, and beyond.

Crop water footprints and their driving mechanisms show regional differences.

Identifying crop water footprints and their driving mechanisms is of significant importance for regional water resources management and ecological sustainability. However, there is currently a lack of comparative studies on drivers of crop water footprint among multiple regional types. In this study, based on quantifying the crop water footprints in seven regions (North China, Northeast China, East China, Central China, South China, Southwest China, and Northwest China) in mainland China from 1996 to 2020, the path analysis method was used to reveal their driving mechanisms. The results showed that the average annual agricultural water footprint was 1448.2 Gm3, with blue water, green water, and grey water accounting for 10.1 %, 66.6 %, and 23.3 %, respectively. Fruits and cereals jointly contributed 80 % of the total water footprint. The crop water footprint in East China was significantly higher than in other regions, accounting for 29.3 % of the national water footprint. The average crop production water footprint was 1080.4 mm, with the highest values observed in East China and South China, and the lowest in Northeast China and Southwest China. Except for East China, the crop production water footprint in other regions showed an increasing trend over time. Irrigation area ratio had the greatest impact on crop production water footprint except for Northeast China, while chemical fertilizer consumption significantly influenced crop production water footprints in North, East, Central, Southwest and Northwest China. Additionally, per capita GDP, per capita net income and irrigation water use efficiency also had considerable effects on crop production water footprint in Northwest China. The research findings can provide a valuable reference for the development of strategies for the efficient and sustainable utilization of agricultural water resources in different regions.

Genome-Wide Identification and Expression Analysis of bZIP Family Genes in Stevia rebaudiana.

The basic (region) leucine zippers (bZIPs) are evolutionarily conserved transcription factors widely distributed in eukaryotic organisms. In plants, they are not only involved in growth and development, defense and stress responses and regulation of physiological processes but also play a pivotal role in regulating secondary metabolism. To explore the function related to the bZIP gene family in Stevia rebaudiana Bertoni, we identified 105 SrbZIP genes at the genome-wide level and classified them into 12 subfamilies using bioinformation methods. Three main classes of cis-acting elements were found in the SrbZIP promoter regions, including development-related elements, defense and stress-responsive elements and phytohormone-responsive elements. Through protein-protein interaction network of 105 SrbZIP proteins, SrbZIP proteins were mainly classified into four major categories: ABF2/ABF4/ABI5 (SrbZIP51/SrbZIP38/SrbZIP7), involved in phytohormone signaling, GBF1/GBF3/GBF4 (SrbZIP29/SrbZIP63/SrbZIP60) involved in environmental signaling, AREB3 (SrbZIP88), PAN (SrbZIP12), TGA1 (SrbZIP69), TGA4 (SrbZIP82), TGA7 (SrbZIP31), TGA9 (SrbZIP95), TGA10 (SrbZIP79) and HY5 (SrbZIP96) involved in cryptochrome signaling, and FD (SrbZIP72) promoted flowering. The transcriptomic data showed that SrbZIP genes were differentially expressed in six S. rebaudiana cultivars ('023', '110', 'B1188', '11-14', 'GP' and 'GX'). Moreover, the expression levels of selected 15 SrbZIP genes in response to light, abiotic stress (low temperature, salt and drought), phytohormones (methyl jasmonate, gibberellic acid and salicylic acid) treatment and in different tissues were analyzed utilizing qRT-PCR. Some SrbZIP genes were further identified to be highly induced by factors affecting glycoside synthesis. Among them, three SrbZIP genes (SrbZIP54, SrbZIP63 and SrbZIP32) were predicted to be related to stress-responsive terpenoid synthesis in S. rebaudiana. The protein-protein interaction network expanded the potential functions of SrbZIP genes. This study firstly provided the comprehensive genome-wide report of the SrbZIP gene family, laying a foundation for further research on the evolution, function and regulatory role of the bZIP gene family in terpenoid synthesis in S. rebaudiana.

Kernel Bioassay Evaluation of Maize Ear Rot and Genome-Wide Association Analysis for Identifying Genetic Loci Associated with Resistance to Fusarium graminearum Infection.

Gibberella ear rot (GER) caused by Fusarium graminearum (teleomorph Gibberella zeae) is one of the most destructive diseases in maize, which severely reduces yield and contaminates several potential mycotoxins in the grain. However, few efforts had been devoted to dissecting the genetic basis of maize GER resistance. In the present study, a genome-wide association study (GWAS) was conducted in a maize association panel consisting of 303 diverse inbred lines. The phenotypes of GER severity were evaluated using kernel bioassay across multiple time points in the laboratory. Then, three models, including the fixed and random model circulating probability unification model (FarmCPU), general linear model (GLM), and mixed linear model (MLM), were conducted simultaneously in GWAS to identify single-nucleotide polymorphisms (SNPs) significantly associated with GER resistance. A total of four individual significant association SNPs with the phenotypic variation explained (PVE) ranging from 3.51 to 6.42% were obtained. Interestingly, the peak SNP (PUT-163a-71443302-3341) with the greatest PVE value, was co-localized in all models. Subsequently, 12 putative genes were captured from the peak SNP, and several of these genes were directly or indirectly involved in disease resistance. Overall, these findings contribute to understanding the complex plant-pathogen interactions in maize GER resistance. The regions and genes identified herein provide a list of candidate targets for further investigation, in addition to the kernel bioassay that can be used for evaluating and selecting elite germplasm resources with GER resistance in maize.

The Effect of Brief Mindfulness Meditation on Suicidal Ideation, Stress and Sleep Quality.

OBJECTIVES: Suicide is the fourth leading cause of death for individuals aged 15-29 years, and early intervention on suicidal ideation and risk factors should be priortized. Brief mindfulness meditation (BMM) is convenient and cost-effective in improving physical and mental well-being, but less is known about its efficacy for suicidal ideation, stress and sleep quality. We investigated the effects of BMM on suicidal ideation, stress, and sleep quality for individuals with suicide risk. METHODS: Sixty-four college students with high suicidal ideation (aged 18-30 years) were randomly allocated to either a BMM (n = 32) or control group (n = 32). The BMM was based on Anapanasati and core mindfulness concepts. Sixty participants completed all scheduled sessions including pretest, one month of intervention or waiting, and posttest. Suicidal ideation was measured with the Beck Scale for Suicidal Ideation. Stress was evaluated using the Perceived Stress Scale and salivary cortisol levels. Sleep was measured using the Pittsburgh Sleep Quality Index and actigraphy accompanied with 7-day sleep diaries. RESULTS: Post-intervention, the BMM group showed significant decrease in suicidal ideation with a large effect size; the decrease showed a medium effect size in the control group. The BMM group, but not the control group, showed significant decrease in morning salivary cortisol and sleep latency, and improved sleep efficiency. CONCLUSIONS: BMM could help reduce suicidal ideation, stress, and sleep disturbance for individuals with high suicidal ideation and it may implicate effective suicide prevention strategy.

Assessment of the regional agricultural water-land Nexus in China: A green-blue water perspective.

An appropriate agricultural water-land nexus can help to effectively take advantage of limited water and land resources, which is of great significance for guaranteeing food security. An R index was proposed to evaluate the regional agricultural water-land nexus from a green-blue water perspective in the current paper. The effects of irrigation on the agricultural water-land nexus were revealed for the first time based on this index in evaluations of all (Rt) and irrigated (Ri) arable land in the 31 provinces, autonomous regions and municipalities (PAMs) of China during 1999-2018. The national annual average values of Rt and Ri were 1.94 and 3.55 m3/m2, respectively; the former was steady during the observed period, while the latter showed a significant decreasing trend (P < 0.01) from 4.35 m3/m2 in 1999 to 2.66 m3/m2 in 2018. The values of both Rt and Ri values in South China were higher than those in North China. The maximum values of Rt and Ri appeared in Xizang (Rt = 99.15 m3/m2; Ri = 201.99 m3/m2), while the minimum values occurred in Ningxia (Rt = 0.30 m3/m2; Ri = 0.44 m3/m2). The Gini coefficient for Ri (Gi) in each year was higher than that for Rt (Gt), demonstrating that the agricultural water-land nexus in irrigated arable land was highly imbalanced during the last two decades. From the perspective of the equitable distribution of irrigation water, irrigation facilities should be developed in the Southeast and Southwest PAMs to improve the effective irrigation rate. In addition, the government should simultaneously implement water transfer plans to reduce the agricultural water pressure in the PAMs in the North China Plain and Northeast China.

Unravelling resources use efficiency and its drivers for water transfer and grain production processes in pumping irrigation system.

Improving the resource utilization efficiency in irrigation systems contributes to the sustainability of the regional water-energy-grain nexus. Based on the water, energy and grain relationships quantification, the comprehensive efficiency (CE) of water transfer and grain production processes and its driving mechanism were analyzed, considering a pumping irrigation system in the Lianshui irrigation district (LID) in eastern China, as a case study. The annual crop output, crop water footprint, and electric energy consumption were estimated as 905.3 M kg (1 M = 106), 914.7 M m3 (50.7% blue water), and 3004.0 kWh, respectively, from 2005 to 2018; the corresponding crop water productivity (CWP), electricity energy productivity (EEP), water intake efficiency of electric energy (WIE) were 0.91 kg/m3, 80.39 kg/kJ, and 75.22 m3/kJ, respectively. CWP, EEP, and WIE varied among crops; however, none of the three indicators showed an obvious trend of change with time. The CE of integrated grain was 0.48 and showed an increase over time, indicating that the sustainability of the studied pumping irrigation system was improving. The driving effect of artificial factors (e. g. social development, agricultural input, and water management) on the CE was more obvious than that of natural conditions (e. g. climate). Increasing agricultural machinery and urbanization rates and reducing the agricultural water rate are conducive to improving the resource utilization efficiency in pumping irrigation systems. The analysis framework coupling water footprint and traditional paradigms proposed in this paper provides a feasible approach for the stability and sustainability of irrigated agricultural systems observation.

Water resource use and driving forces analysis for crop production in China coupling irrigation and water footprint paradigms.

The crop water relationship quantification is conducive to decision-making for regional food safety and resource conservation. However, irrigation water and crop water footprint (CWF) was observed separately in previous studies, which leads to incomplete evaluation of water resource occupation in agricultural system. The crop water resource use (WRU), combining WF and irrigation water accounting, in 31 provinces of China from 1999 to 2018 was estimated in current paper. The driving forces of WRU were analyzed using the logarithmic mean divisia index (LMDI) model, based on its spatial and temporal patterns demonstration. The results showed that national WRU increased from 1051.6 Gm3 in 1999 to 1676.4 Gm3 in 2018, with an average annual growth rate of 2.48%. The provinces with high WRU were mainly distributed in North China and Northeast China. Hebei, Shandong, and Henan jointly contributed 28.9% of the national WRU. In addition, economic level was the largest contributor to promote the growth of WRU, and water use intensity was the most important contributor to inhibit the growth of WRU. Economic level, resource endowment, and population size had a promoting effect on WRU in Northeast, Northwest, North China, and Southeast provinces, while water use intensity, irrigation technique, and urbanization degree showed inhibitory effect in Northeast, Northwest, and Southwest provinces. It is meaningful to combine water footprint and irrigation water use for agricultural water management and conservation. The arid North China Plain should adopt water-saving irrigation and rainwater recycling technologies to control WRU, and the Northeast granary should reduce WRU by strengthening water pollution prevention and improving water resources scheduling to ensure food security and sustainable use of water resources.

The Efficacy and Mechanism of Proteasome Inhibitors in Solid Tumor Treatment.

BACKGROUND: The ubiquitin-proteasome system (UPS) is critical in cellular protein degradation and widely involved in the regulations of cancer hallmarks. Targeting the UPS pathway has emerged as a promising novel treatment in hematological malignancies and solid tumors. OBJECTIVE: This review mainly focuses on the preclinical results of proteasome inhibitors in solid tumors. METHODS: We analyzed the published articles associated with the anticancer results of proteasome inhibitors alone or combination chemotherapy in solid tumors. Important data presented in abstract form were also discussed in this review. RESULTS/CONCLUSION: Proteasome inhibitors, such as bortezomib and carfilzomib, are highly effective in treating solid tumors. The anticancer efficacy is not limited to affect the proteasomal inhibition- associated signaling pathways but also widely involves the signaling pathways related to cell cycle, apoptosis, and epithelial-mesenchymal transition (EMT). In addition, proteasome inhibitors overcome the conventional chemo-resistance of standard chemotherapeutics by inhibiting signaling pathways, such as NF-κB or PI3K/Akt. Combination chemotherapy of proteasome inhibitors and standard chemotherapeutics are widely investigated in multiple relapsed or chemo-resistant solid tumor types, such as breast cancer and pancreatic cancer. The proteasome inhibitors re-sensitize the standard chemotherapeutic regimens and induce synergistic anticancer effects. The development of novel proteasome inhibitors and delivery systems also improves the proteasome inhibitors' anticancer efficacy in solid tumors. This review summarizes the current preclinical results of proteasome inhibitors in solid tumors and reveals the potential anticancer mechanisms.

Childhood Trauma and Suicide: The Mediating Effect of Stress and Sleep.

This study aimed to investigate the relationship between suicide risk, perceived stress, and sleep quality through a structural equation modeling approach. This study used convenience sampling to survey 780 undergraduate and graduate students aged 18-30 years. Students were invited to participate in the online questionnaires, which included the Beck Scale for Suicide Ideation, the Suicidal Behaviors Questionnaire-Revised, the Perceived Stress Scale, the Childhood Trauma Questionnaire-Short Form, and the Pittsburgh Sleep Quality Index. The results showed that suicide ideation and suicidal behavior were positively correlated with childhood trauma, stress, and sleep. A well-fitted structural equation model (χ2 = 1.52, df = 1, χ2/df = 1.52, RMSEA = 0.03, CFI = 1.00, NFI = 1.00) was constructed in this study. The hierarchical regression test showed significance in all the path coefficients of the model. The total effect of emotional abuse on suicide behaviors was 49.5%. The mediating effects accounted for 73.7% of the total effects of emotional abuse on suicidal behaviors. The results demonstrate efforts targeting stress and poor sleep might mitigate the risk of suicidal behaviors among individuals with early emotional abuse experiences.